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List Of Combined Sex-hormonal Preparations
This is a list of known combined sex-hormonal formulations. Brand names and developmental code names are in parentheses. Androgens Injection Marketed * Nandrolone decanoate/nandrolone phenylpropionate (Dinandrol) * Testosterone propionate/testosterone isocaproate/testosterone caproate (Androteston PP) * Testosterone propionate/testosterone enanthate/testosterone undecylenate (Durasteron) * Testosterone propionate/testosterone enanthate (Testoviron Depot) * Testosterone propionate/testosterone ketolaurate (Testosid Depot) * Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate (Sustanon 100) * Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone caproate (Omnadren 250) * Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone decanoate (Sustanon 250) * Testosterone propionate/testosterone valerate/testosterone undecylenate (Triolandren) * Testosterone propionate/testost ...
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Combination Drug
A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. Terms like "combination drug" or "combination drug product" can be common shorthand for a FDC product (since most combination drug products are currently FDCs), although the latter is more precise if in fact referring to a mass-produced product having a predetermined combination of drugs and respective dosages (as opposed to ''customized'' polypharmacy via compounding). And it should also be distinguished from the term "combination product" in medical contexts, which without further specification can refer to products that combine different ''types'' of medical products—such as device/drug combinations as opposed to drug/drug combinations. Note that when a combination drug product (whether fixed-dose or not) is a "pill" (i.e., a tablet or capsule), then it may also be a kind of " polypill" or combopill. Initially, fixed-dose combinat ...
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Esterified Estrogens
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men. It is formulated alone or in combination with methyltestosterone. It is taken by mouth. Side effects of EEs include nausea, breast tension, edema, and breakthrough bleeding among others. It is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. EEs are a prodrug mainly of estradiol and to a lesser extent of equilin. EEs were introduced for medical use by 1970. They are available in only a few countries, such as Chile and the United States. They have also been marketed in Argentina and Switzerland in the past. Medical uses EEs are used in hormone therapy for menopausal symptoms, female hypogonadism, ovariectomy, and primary ovarian failu ...
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Esterified Estrogens/methyltestosterone
Esterified estrogens/methyltestosterone (EEs/MT), sold under brand names such as Covaryx, Eemt, Essian, Estratest, Menogen, and Syntest, is a hormonal preparation that combines esterified estrogens (EEs) with methyltestosterone (MT) in one tablet and is used in menopausal hormone therapy. Medical uses EEs/MT is used to treat menopausal women who suffer from hot flashes, but do not get relief from estrogen-only therapy. Available forms EEs/MT is sold in tablet form, with either 1.25 mg EEs/2.5 mg MT or 0.625 mg EEs/1.25 mg MT available. Pharmacology The product is a combination of esterified estrogens, an estrogen, and low-dose methyltestosterone, an androgen/anabolic steroid, in a single tablet. History EEs/MT was first marketed in the United States in 1965 by Reid-Provident Laboratories, which as 100% of Reid-Rowell, Inc. stock was acquired by the Belgian pharmaceutical company Solvay in 1986. There has been some controversy surrounding the drug in recent years as to its ...
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Dienestrol Diacetate/methyltestosterone
Dienestrol (, ) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (), is a synthetic nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe. It has been studied for use by rectal administration in the treatment of prostate cancer in men as well. The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene. Dienestrol is a close analogue of diethylstilbestrol. It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively. Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically. Isomers Dienestrol structure.svg, Dienestrol (unspecified) - CA 84-17-3E,E-Dienestrol structure.svg, ''E'',''E''-Dienestrol - CA13029-44-2Z,Z-Dienestrol structure.svg ...
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Conjugated Estrogens/methyltestosterone
Conjugated estrogens/methyltestosterone (CEEs/MT), sold under the brand name Premarin with Methyltestosterone, is a combination of conjugated estrogens (CEEs), an estrogen, and methyltestosterone (MT), an androgen and anabolic steroid (AAR), which is used in menopausal hormone therapy for women. It contains 0.625 to 1.25 mg CEEs and 5 to 10 mg MT. The medication was marketed by Wyeth-Ayerst. CEEs/MT was previously marketed in the United States and Canada. It remains available only in Paraguay, under the brand names Delitan and Delitan Forte. See also * Esterified estrogens/methyltestosterone * List of combined sex-hormonal preparations This is a list of known combined sex-hormonal formulations. Brand names and developmental code names are in parentheses. Androgens Injection Marketed * Nandrolone decanoate/nandrolone phenylpropionate (Dinandrol) * Testosterone propionate/ ... References Abandoned drugs Combined estrogen–androgen formulations ...
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Progesterone/hydroxyprogesterone Heptanoate/α-tocopherol Palmitate
Progesterone/hydroxyprogesterone heptanoate/α-tocopherol palmitate (P4/OHPH/VE), sold under the brand name Tocogestan, is a combination medication of progesterone (P4), a short-acting progestogen, hydroxyprogesterone heptanoate (OHPH), a long-acting progestogen, and α-tocopherol palmitate, a prodrug of α-tocopherol and form of vitamin E, which was previously used in France to support pregnancy in women but is no longer available. Laurent, M. (1996). Progestatifs et anti-androgènes. CNGOF Collège national des gynécologues et obstétriciens français. Mises à jour en Gynécologie et Obstétrique. Paris: Vigot, 157-192. "d. Voie intramusculaire (Tocogestan®) : c’est une solution huileuse comprenant un mélange de progestérone naturelle et d’heptanoate de 17-OH-progestérone ; ce dernier lui confère une durée d’action prolongée permettant d’espacer les injections. ..L’estérification par l’acide caproïque (Progestérone retard®) ou heptanoïque (Tocogestan� ...
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Estradiol/estradiol Enanthate
Estradiol/estradiol enanthate (E2/E2-EN) is an injectable combination formulation of estradiol (E2), a short-acting estrogen, and estradiol enanthate (E2-EN), a long-acting estrogen, which was developed by Boehringer around 1960 for potential medical use but was never marketed. It contained 1 mg E2 and 9 mg E2-EN in oil solution and was intended for administration by intramuscular injection. A single intramuscular injection of E2/E2-EN (1 mg/9 mg) has been found to result in a 10-fold increase in estradiol excretion on the 2nd day post-injection (due to the 1 mg short-acting E2 component). Following this, estradiol excretion remained above the menstrual-cycle average for 10 days post-injection and did not return to baseline until the 24th day post-injection (due to the 9 mg long-acting E2-EN component). E2/E2-EN is similar to estradiol benzoate/estradiol phenylpropionate (brand name Dimenformon Prolongatum), another injectable combination m ...
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