Erwin Friedrich Wagner (born 25 November 1950) is an

Austria Austria, , bar, Östareich officially the Republic of Austria, is a country in the southern part of Central Europe, lying in the Eastern Alps. It is a federation of nine states, one of which is the capital, Vienna, the most populous ...

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

known for his research on the molecular basis of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

and associated conditions such as

inflammation Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving im ...

and

cachexia Cachexia () is a complex syndrome associated with an underlying illness, causing ongoing muscle loss that is not entirely reversed with nutritional supplementation. A range of diseases can cause cachexia, most commonly cancer, congestive heart f ...

. He was deputy director of the Spanish National Cancer Research Center (CNIO) in

Madrid Madrid ( , ) is the capital and most populous city of Spain. The city has almost 3.4 million inhabitants and a metropolitan area population of approximately 6.7 million. It is the second-largest city in the European Union (EU), and ...

, Spain, until 2019. Since 2019, Wagner is a group leader affiliated with the

Medical University of Vienna The Medical University of Vienna (German: ''Medizinische Universität Wien'') is a public university located in Vienna, Austria. It is the direct successor to the faculty of medicine at the University of Vienna, founded in 1365 by Rudolf IV, Duk ...

Early life and education

Erwin Wagner was born in Wolfsberg in the south of Austria. From 1974, he studied technical chemistry at the

University of Graz The University of Graz (german: link=no, Karl-Franzens-Universität Graz, ), located in Graz, Austria, is the largest and oldest university in Styria, as well as the second-largest and second-oldest university in Austria. History The unive ...

, obtaining an engineering degree in 1974. In 1975, he worked in the lab of Fritz Paltauf on lipid chemistry. During his PhD studies, Erwin Wagner joined the

Max Planck Institute for Molecular Genetics The Max Planck Institute for Molecular Genetics is a research institute for molecular genetics based in Berlin, Germany. It is part of the Max Planck Institute network of the Max Planck Society for the Advancement of Science. Departments and rese ...

Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...

with a Max Planck Fellowship for one year in 1976. He then joined the lab of Manfred Schweiger at the

University of Innsbruck The University of Innsbruck (german: Leopold-Franzens-Universität Innsbruck; la, Universitas Leopoldino Franciscea) is a public research university in Innsbruck, the capital of the Austrian federal state of Tyrol, founded on October 15, 1669. ...

in 1977. Wagner obtained his PhD with a thesis on “Regulation of gene expression after virus infection” in 1978.Wagner, Erwin CV
ae-info.org

Career

In 1979, Erwin Wagner began his postdoctoral research at the

Fox Chase Cancer Center Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are loca ...

Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Sinc ...

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

in the laboratory of

Beatrice Mintz Beatrice Mintz (January 24, 1921 – January 3, 2022) was an American embryologist who contributed to the understanding of genetic modification, cellular differentiation, and cancer, particularly melanoma.Martha J. Bailey, ''American women in ...

as a Max Kade Fellow. Wagner's worked focused on the genetic control of mouse development working to develop techniques allowing the micro-injection of DNA into fertilized eggs as well as the development of gene transfer technologies into

stem cells In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

and mice. In 1983, Wagner obtained a lecture qualification (Habilitation) by Innsbruck University and became a Group Leader at the

European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 and ...

Heidelberg Heidelberg (; Palatine German language, Palatine German: ''Heidlberg'') is a city in the States of Germany, German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914 ...

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

. In 1988, Wagner was appointed senior scientist at the then newly founded

Research Institute of Molecular Pathology The Research Institute of Molecular Pathology (IMP) is a biomedical research center, which conducts curiosity-driven basic research in the molecular life sciences. The IMP is located at the Vienna Biocenter in Vienna, Austria. The institute emplo ...

(IMP) in

Vienna en, Viennese , iso_code = AT-9 , registration_plate = W , postal_code_type = Postal code , postal_code = , timezone = CET , utc_offset = +1 , timezone_DST ...

. Wagner was a founding member of the IMP. From 1997 until 2008, Wagner was appointed the Deputy Director of the IMP. In 2008, Wagner left the IMP to become Deputy Director and Head of the Cancer Cell Biology Program at the Spanish National Cancer Research Center (CNIO) in Madrid, Spain. In 2018, Wagner left CNIO and returned to Vienna in January 2019, where he is a Group Leader affiliated with the Department of Dermatology and Department of Laboratory Medicine at the Medical University of Vienna. He is a member of the Editorial Board for ''

Developmental Cell ''Developmental Cell'' is a peer-reviewed scientific journal of cell and developmental biology. The journal was established in 2001, and is edited by Julie Sollier. It published by Cell Press, an imprint of Elsevier, and its articles becomes open ...

''.

Research

Erwin Wagner's studies are focused in the area of

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

function in both healthy and pathological states. His work is focused in the fields of cancer biology and tumor development. He investigates the functions of transcription factor complexes regulating

cell proliferation Cell proliferation is the process by which ''a cell grows and divides to produce two daughter cells''. Cell proliferation leads to an exponential increase in cell number and is therefore a rapid mechanism of tissue growth. Cell proliferation re ...

, differentiation and

oncogenesis Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnor ...

, as well as the cross-talk between organs, in both mice models and humans. He works to define and understand the molecular pathways that lead to disease, cancer development and works to identify novel therapeutic targets to treat human disease.

Awards and achievements

EMBO Gold Medal The EMBO Gold Medal is an annual award of the European Molecular Biology Organization (EMBO) given to young scientists for outstanding contributions to the life sciences in Europe. Laureates receive a medal and €10,000 and are invited to rec ...

(1990); *Max Planck Research Prize (1993); *Alois Sonnleitner Prize of the Austrian Academy of Sciences (1995); *

Wittgenstein Award The Wittgenstein Award (german: Wittgenstein-Preis) is an Austrian science award supporting the notion that "scientists should be guaranteed the greatest possible freedom and flexibility in the performance of their research." The prize money of up ...

of the Austrian government (1996); *Charles Rodolphe Brupbacher Award for Cancer Research (2003). He was elected member of the

European Molecular Biology Organisation The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

(EMBO) in 1988; of the

Academia Europaea The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europea ...

in 1998; corresponding membership of the Austrian Academy of Sciences in 2005; and International Member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(NAS) in 2021. He won two ERC Advanced Grants, one in 2009, one in 2017.

References

External links

Research group website of Erwin Wagner at the Medical University of Vienna
{{DEFAULTSORT:Wagner, Erwin Friedrich Living people 1950 births University of Graz alumni Austrian biochemists