Eric George Lapthorne Bywaters (1 June 1910 – 2 April 2003) was a British physician.

Early years

Bywaters studied at the

Middlesex Hospital Medical School Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally clos ...

, graduating in 1933 with a gold medal and honours in pathology, and then worked as an assistant to pathologist

Lionel Whitby Brigadier Sir Lionel Ernest Howard Whitby, CVO, MC (8 May 1895 – 24 November 1956) was a British haematologist, British Army officer and academic. He served as Regius Professor of Physic at the University of Cambridge from 1945 to 1956, Maste ...

Career

In 1937 he was invited by

rheumatologist Rheumatology (Greek ''ῥεῦμα'', ''rheûma'', flowing current) is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatolog ...

Walter Bauer Walter Bauer (; 8 August 1877 – 17 November 1960) was a German theologian, lexicographer of New Testament Greek, and scholar of the development of Early Christianity. Life Bauer was born in Königsberg, East Prussia, and raised in Marburg, ...

to work at

Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...

and perform research on

lupus erythematosus Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blo ...

. When war broke out in 1939, Bywaters returned to Britain, but was not taken into the army because of kidney problems and instead took over

Rheumatology Rheumatology (Greek ''ῥεῦμα'', ''rheûma'', flowing current) is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatolog ...

at the

British Postgraduate Medical School The Royal Postgraduate Medical School (RPMS) was an independent medical school, based primarily at Hammersmith Hospital in west London. In 1988, the school merged with the Institute of Obstetrics & Gynaecology, and in 1997 became part of Imperial ...

Hammersmith Hospital Hammersmith Hospital, formerly the Military Orthopaedic Hospital, and later the Special Surgical Hospital, is a major teaching hospital in White City, West London. It is part of Imperial College Healthcare NHS Trust in the London Borough of H ...

. During the bombing of London, he clarified that so-called

crush syndrome Crush syndrome (also traumatic rhabdomyolysis or Bywaters' syndrome) is a medical condition characterized by major shock and kidney failure after a crushing injury to skeletal muscle. Crush ''injury'' is compression of the arms, legs, or other p ...

was

renal failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

in wounded bomb victims who had been freed from crushing injuries. Bywater traced the condition to the release of

myoglobin Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the cardiac and skeletal muscle tissue of vertebrates in general and in almost all mammals. Myoglobin is distantly related to hemoglobin. Compared to hemoglobin, myoglobi ...

from injured muscle tissue entering the

bloodstream The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...

. He found a method of treatment in the form of intravenous or oral administration of

alkaline In chemistry, an alkali (; from ar, القلوي, al-qaly, lit=ashes of the saltwort) is a base (chemistry), basic, ionic compound, ionic salt (chemistry), salt of an alkali metal or an alkaline earth metal. An alkali can also be defined as ...

fluids. After the war, he built up rheumatology as an independent medical discipline. In 1947, he became director of a small hospital department for rheumatism sufferers at the

Canadian Red Cross Memorial Hospital The Canadian Red Cross Memorial Hospital in Taplow, Buckinghamshire, was a civilian hospital and a centre for research into rheumatism in children until its closure in 1985. History War time origins In 1914, during the First World War, th ...

in the village of

Taplow Taplow is a village and civil parish in the Unitary Authority of Buckinghamshire, England. It sits on the left bank of the River Thames, facing Maidenhead in the neighbouring county of Berkshire, with Cippenham and Burnham to the east. It is th ...

, near

Maidenhead Maidenhead is a market town in the Royal Borough of Windsor and Maidenhead in the county of Berkshire, England, on the southwestern bank of the River Thames. It had an estimated population of 70,374 and forms part of the border with southern Bu ...

Berkshire Berkshire ( ; in the 17th century sometimes spelt phonetically as Barkeshire; abbreviated Berks.) is a historic county in South East England. One of the home counties, Berkshire was recognised by Queen Elizabeth II as the Royal County of Berk ...

. Immediately after the discovery of the therapeutic effect of

cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enzy ...

against rheumatic fever by

Philip Showalter Hench Philip Showalter Hench (February 28, 1896 – March 30, 1965) was an American physician. Hench, along with his Mayo Clinic co-worker Edward Calvin Kendall and Swiss chemist Tadeus Reichstein was awarded the Nobel Prize for Physiology or Medici ...

and

Edward Calvin Kendall Edward Calvin Kendall (March 8, 1886 – May 4, 1972) was an American chemist. In 1950, Kendall was awarded the Nobel Prize for Physiology or Medicine along with Swiss chemist Tadeusz Reichstein and Mayo Clinic physician Philip S. Hench, for the ...

he undertook clinical tests that confirmed this (participation in 1948). The approach of treating

rheumatic heart disease Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful jo ...

using cortisone, was eventually made irrelevant by the availability of antibiotic treatment, which nearly eliminated the disease in the UK and other developed countries. Bywaters used his expertise as a pathologist for accurate characterization of rheumatic diseases and to develop new methods of treatment of juvenile chronic arthritis in children and adolescents.

Recognition

In 1963 he received the

Canada Gairdner International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

for his work studying rheumatoid arthritis, and he was made a

Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established o ...

in 1975.

Personal life

His hobbies were gardening and painting. He was born on 1 June 1910 in

London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...

and died on 2 April 2003 in

Beaconsfield Beaconsfield ( ) is a market town and civil parish within the unitary authority of Buckinghamshire, England, west-northwest of central London and south-southeast of Aylesbury. Three other towns are within : Gerrards Cross, Amersham and High W ...

, England

References

External links

Obituary
in ''Rheumatology'', Vol 42, 2003
Obituary
in the ''British Medical Journal''
Obituary
in ''Joint Bone Spine''
Obituary
in the ''Roll of the Royal College of Physicians of London''

with Bywaters * {{DEFAULTSORT:Bywaters, Eric 20th-century British medical doctors 1910 births 2003 deaths Commanders of the Order of the British Empire Scientists from London