Theodor Albrecht Edwin Klebs (6 February 1834 – 23 October 1913) was a German-Swiss
microbiologist
A microbiologist (from Ancient Greek, Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of Microorganism, microscopic organisms such as bacteria, algae, f ...
. He is mainly known for his work on
infectious diseases
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...
. His works paved the way for the beginning of modern
bacteriology Bacteriology is the branch and specialty of biology that studies the morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the identification, classificat ...
, and inspired
Louis Pasteur
Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named afte ...
and
Robert Koch
Heinrich Hermann Robert Koch ( , ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist. As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera (though the Vibrio ...
. He was the first to identify a bacterium that causes
diphtheria
Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...
, which was called Klebs–Loeffler bacterium (now ''
Corynebacterium diphtheriae
''Corynebacterium diphtheriae'' is the pathogenic bacterium that causes diphtheria. It is also known as the Klebs–Löffler bacillus, because it was discovered in 1884 by German bacteriologists Edwin Klebs (1834–1912) and Friedrich Löffl ...
'').
He was the father of physician
Arnold Klebs
Arnold C. Klebs (March 17, 1870 – March 6, 1943) was a Swiss physician who specialized in the study of tuberculosis. Born in Bern, Switzerland, Arnold Klebs, the son of renowned bacteriologist Edwin Klebs, was raised in the presence of an exte ...
.
Life
Klebs was born in
Königsberg
Königsberg (, ) was the historic Prussian city that is now Kaliningrad, Russia. Königsberg was founded in 1255 on the site of the ancient Old Prussian settlement ''Twangste'' by the Teutonic Knights during the Northern Crusades, and was named ...
,
Province of Prussia
The Province of Prussia (; ; pl, Prowincja Prusy; csb, Prowincjô Prësë) was a province of Prussia from 1829 to 1878. Prussia was established as a province of the Kingdom of Prussia in 1829 from the provinces of East Prussia and West Prussia ...
. He studied at the
University of Würzburg
The Julius Maximilian University of Würzburg (also referred to as the University of Würzburg, in German ''Julius-Maximilians-Universität Würzburg'') is a public research university in Würzburg, Germany. The University of Würzburg is one of ...
under
Rudolf Virchow
Rudolf Ludwig Carl Virchow (; or ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founder ...
in 1855 and received his doctorate at the
University of Berlin
Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative o ...
in 1858. He achieved his
habilitation
Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a ...
at the
University of Königsberg
The University of Königsberg (german: Albertus-Universität Königsberg) was the university of Königsberg in East Prussia. It was founded in 1544 as the world's second Protestant academy (after the University of Marburg) by Duke Albert of Prussi ...
the following year.
Klebs was an assistant to Virchow at the
Charité
The Charité – Universitätsmedizin Berlin (Charité – Berlin University of Medicine) is one of Europe's largest university hospitals, affiliated with Humboldt University and Free University Berlin. With numerous Collaborative Research Cen ...
in Berlin from 1861 until 1866, when he became a professor of pathology at the
University of Bern
The University of Bern (german: Universität Bern, french: Université de Berne, la, Universitas Bernensis) is a university in the Switzerland, Swiss capital of Bern and was founded in 1834. It is regulated and financed by the Canton of Bern. It ...
in
Switzerland
). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel ...
. He married Rosa Grossenbacher, a Swiss, and also acquired Swiss citizenship. He served as a military physician for the
Prussian Army
The Royal Prussian Army (1701–1919, german: Königlich Preußische Armee) served as the army of the Kingdom of Prussia. It became vital to the development of Brandenburg-Prussia as a European power.
The Prussian Army had its roots in the co ...
in 1870 during the
Franco-Prussian War; several of his ancestors had fought during the
Napoleonic Wars
The Napoleonic Wars (1803–1815) were a series of major global conflicts pitting the French Empire and its allies, led by Napoleon I, against a fluctuating array of European states formed into various coalitions. It produced a period of Fren ...
.
Klebs taught at Würzburg from 1872 to 1873, at
Prague
Prague ( ; cs, Praha ; german: Prag, ; la, Praga) is the capital and largest city in the Czech Republic, and the historical capital of Bohemia. On the Vltava river, Prague is home to about 1.3 million people. The city has a temperate ...
from 1873 to 1882, and at
Zürich
Zürich () is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zürich. It is located in north-central Switzerland, at the northwestern tip of Lake Zürich. As of January 2020, the municipality has 43 ...
from 1882 to 1892. Because of disagreements with the rest of the faculty, the impetuous Klebs resigned from Zürich in 1893 and ran an unsuccessful private business in
Karlsruhe
Karlsruhe ( , , ; South Franconian: ''Kallsruh'') is the third-largest city of the German state (''Land'') of Baden-Württemberg after its capital of Stuttgart and Mannheim, and the 22nd-largest city in the nation, with 308,436 inhabitants. ...
and
Strassburg
Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eur ...
in 1894.
From 1896 to 1900, Klebs taught at
Rush Medical College
Rush Medical College is the medical school of Rush University, located in the Illinois Medical District, about 3 km (2 miles) west of the Loop in Chicago. Offering a full-time Doctor of Medicine program, the school was chartered in 1837, and ...
in
Chicago
(''City in a Garden''); I Will
, image_map =
, map_caption = Interactive Map of Chicago
, coordinates =
, coordinates_footnotes =
, subdivision_type = Country
, subdivision_name ...
, United States. From 1905 to 1910, he was a private researcher in Berlin, after which he returned to Switzerland, living with his oldest son in
Lausanne
, neighboring_municipalities= Bottens, Bretigny-sur-Morrens, Chavannes-près-Renens, Cheseaux-sur-Lausanne, Crissier, Cugy, Écublens, Épalinges, Évian-les-Bains (FR-74), Froideville, Jouxtens-Mézery, Le Mont-sur-Lausanne, Lugrin (FR-74), ...
. Klebs died in Bern.
[
]
Discoveries
In 1883, Klebs successfully identified the bacterium
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
''Corynebacterium diphtheriae'' as the etiological cause of diphtheria
Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...
. This bacterium is also known as the Klebs-Löffler bacillus.
The bacterial genus ''Klebsiella
''Klebsiella'' is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.
''Klebsiella'' species are found everywhere in nature. This is thought to be due to distinct sublineages developin ...
'' is named in honor of his work. Also ''Klebsormidium
''Klebsormidium'' is a genus of filamentous charophyte green algae comprising 20 species. The name was proposed in 1972 to resolve confusion in application and status of Hormidium and was given for the German botanist Georg Albrecht Klebs.
Th ...
'', which is a genus of filamentous charophyte
Charophyta () is a group of freshwater green algae, called charophytes (), sometimes treated as a phylum, division, yet also as a superdivision or an unranked clade. The terrestrial plants, the Embryophyta emerged within Charophyta, possibly fro ...
green algae
The green algae (singular: green alga) are a group consisting of the Prasinodermophyta and its unnamed sister which contains the Chlorophyta and Charophyta/Streptophyta. The land plants (Embryophytes) have emerged deep in the Charophyte alga as ...
comprising 20 species,was also named in his honour in 1972.
Klebs' works preceded some of the most important discoveries in medicine. He described acromegaly
Acromegaly is a disorder that results from excess growth hormone (GH) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. There may also be an enlargement of the forehead, jaw, and nose. Other ...
in 1884, two years before Pierre Marie
Pierre Marie (9 September 1853 – 13 April 1940) was a French neurology, neurologist and political journalist close to the French Section of the Workers' International, SFIO.
Medical Career
After finishing medical school, he served as an int ...
. In 1878, he successfully inoculated syphilis
Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...
in monkeys, antedating Élie Metchnikoff
Ilya Ilyich Mechnikov (russian: Илья Ильич Мечников; – 15 July 1916), also spelled Élie Metchnikoff, was a Russian zoologist best known for his pioneering research in immunology. Belkin, a Russian science historian, explains ...
and Émile Roux
Pierre Paul Émile Roux FRS (17 December 18533 November 1933) was a French physician, bacteriologist and immunologist. Roux was one of the closest collaborators of Louis Pasteur (1822–1895), a co-founder of the Pasteur Institute, and respon ...
by 25 years. He isolated colonies of bacteria nine years before Robert Koch. He was the first to produce tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in ...
experimentally in animals by the injection of milk from infected cows. He identified the typhoid bacillus (now named ''Salmonella typhi
''Salmonella enterica'' subsp. ''enterica'' is a subspecies of '' Salmonella enterica'', the rod-shaped, flagellated, aerobic, Gram-negative bacterium. Many of the pathogenic serovars of the ''S. enterica'' species are in this subspecies, includi ...
'') before Karl Joseph Eberth
Karl Joseph Eberth (21 September 1835 – 2 December 1926) was a German pathologist and bacteriologist who was a native of Würzburg.
Biography
In 1859 he earned his doctorate at the University of Würzburg, and became an assistant to anatomis ...
.
Fundamental tests in bacteriology
Klebs identified four "''Grundversuche''" (fundamental tests) that provided a basis for his own research strategy, as well as general bacteriological research. According to Klebs, the bacteriological tests consist of the following postulates:
*First, all bacteria are pathological.
*Second, bacteria never occur spontaneously.
*Third, every disease is caused only by bacteria.
*Fourth, the bacteria that cause distinguishable disease are distinguishable.
Although some of these hypotheses are literally false, they are in general the foundation of modern experiments in bacteriology.
Scientific blunders
Klebs made some significant errors about infectious diseases. He believed, for example, that malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. S ...
was caused by a bacterium. In 1879, Corrado Tommasi-Crudeli and he claimed that they isolated a bacterium from the waters of Pontine Marshes in Roman Campagna
The Roman Campagna () is a low-lying area surrounding Rome in the Lazio region of central Italy, with an area of approximately .
It is bordered by the Tolfa and Sabatini mountains to the north, the Alban Hills to the southeast, and the Tyrrhenia ...
. They concluded that the bacterium was the pathogen for malaria as they discovered it from damp soil in the region of malaria epidemics. They gave it the name ''Bacillus malariae''. They further experimented with the bacterial isolate
Isolate may refer to:
Arts, entertainment, and media
* ''Isolate'' (film), a 2013 Australian film
* ''Isolate'' (Circus Maximus album), 2007
* ''Isolate'' (Gary Numan album), 1992
Language
* Isolating language, with near-unity morpheme/word ...
which they injected into rabbits. They observed that infected rabbits developed fever and enlarged spleen, characteristics of malaria. They proposed that the malarial bacterium was transmitted by drinking contaminated water or inhalation from air. Klebs reported that antimalarial drug quinine
Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to ''Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg cr ...
killed the germ. The discovery was supported by leading malariologists of the time. It was then declared that the malaria problem was solved. When a French Army physician Charles Alphonse Laveran correctly discovered in 1880 that malaria was caused by a protozoan
Protozoa (singular: protozoan or protozoon; alternative plural: protozoans) are a group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic tissues and debris. Histo ...
parasite (which he called ''Oscillaria malariae'', now ''Plasmodium falciparum
''Plasmodium falciparum'' is a Unicellular organism, unicellular protozoan parasite of humans, and the deadliest species of ''Plasmodium'' that causes malaria in humans. The parasite is transmitted through the bite of a female ''Anopheles'' mosqu ...
''), the discovery was ignored in preference of the bacillus theory of Klebs and Tommasi-Crudeli. An American physician, though, George Miller Sternberg
Brigadier General George Miller Sternberg (June 8, 1838 – November 3, 1915) was a U.S. Army physician who is considered the first U.S. bacteriologist, having written ''Manual of Bacteriology'' (1892). After he survived typhoid and yellow fever, ...
, proved that the bacillus did not cause specific symptoms of malaria in 1881. The bacillus theory was eventually proved wrong by the experimental demonstration of the mosquito-malaria theory
Mosquito-malaria theory (or sometimes mosquito theory) was a scientific theory developed in the latter half of the 19th century that solved the question of how malaria was transmitted. The theory proposed that malaria was transmitted by mosquitoes ...
in 1898.
Klebs also made mistakes in claiming the existence of ''Microzoon septicum'' as causative agent of wound infection, and "monadines" as the pathogen for rheumatism
Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including art ...
.[
]
References
Further reading
Klebs, Edwin – The Columbia Encyclopedia, Sixth Edition. 2001–05
External links
*
Bio at the University of Würzburg
Biography at Encyclopædia Britannica
{{DEFAULTSORT:Klebs, Edwin
1834 births
1913 deaths
German pathologists
German military personnel of the Franco-Prussian War
German military doctors
Swiss biologists
Physicians from Königsberg
People from the Province of Prussia
University of Würzburg alumni
University of Würzburg faculty
Humboldt University of Berlin alumni
University of Königsberg alumni
University of Bern faculty
Charles University faculty
University of Zurich faculty
Diphtheria
German emigrants to Switzerland