Edward F. Fritsch (born June 1, 1950) is a scientist in the field of

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and

cancer immunology Cancer immunology is an interdisciplinary branch of biology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilis ...

. As a postdoctoral fellow under Tom Maniatis at

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

, Fritsch entered the field of recombinant DNA by constructing the first complete library of the human genome along with Dr. Richard Lawn. In 1982, Fritsch, Joe Sambrook and Tom Maniatis, wrote ''Molecular Cloning: A Laboratory Manual'', which was considered "omnipresent in Molecular Biology laboratories and ..utilized to the point where it is frequently referred to as ‘The Bible’.” Fritsch helped initiate and for four years co-taught the widely successful Cold Spring Harbor course on Molecular Cloning. Fritsch's work in molecular cloning continued at Genetics Institute, acquired by

Wyeth Wyeth, LLC was an American pharmaceutical company. The company was founded in Philadelphia, Pennsylvania, in 1860 as ''John Wyeth and Brother''. It was later known, in the early 1930s, as American Home Products, before being renamed to Wyeth in ...

in 1992, where he worked on the discovery and production of therapeutic recombinant proteins, including the cloning of the erythropoietin (EPO) gene Fritsch then joined Phylos, Inc. to utilize a in vitro, directed-evolution technology to discover new protein therapeutics, eventually becoming Chief Scientific Officer He later worked with Cathy Wu and Nir Hacohen at the

Dana–Farber Cancer Institute Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by ...

and the

Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institu ...

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ...

and Harvard,. There he led the development of NeoVax, a first-in-class personalized neoantigen cancer vaccine through IND approval and successful execution of two clinical trials In 2015, he co-founded Neon Therapeutics, Inc., (acquired by BioNTech in 2020 for $67M), as Chief Technology Officer to work on personalizedcancer vaccines. In 2019, he left Neon to re-join the Dana–Farber Cancer Institute and the Broad Institute to continue work on the subject.

References

{{DEFAULTSORT:Fritsch, Edward F. 1950 births Living people American molecular biologists