Ed Harlow (born 1952) is an American molecular biologist. Harlow received the Ph.D. degree from the Imperial Cancer Research Fund Laboratories in London. Harlow is professor of Biological Chemistry and Molecular Pharmacology at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

. He has been associate director of the

Dana–Farber Cancer Institute Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated b ...

as well as research director of the

Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...

Cancer Center and the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

. From 2009 to 2011 he was Chief Scientific Officer at Constellation Pharmaceuticals. Among Harlow's discoveries was the demonstration that the

retinoblastoma protein The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated ''Rb'', ''RB'' or ''RB1'') is a proto-oncogenic tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive ...

interacts with viral transforming proteins, thereby linking tumor viruses with the cell cycle. He is also the author, with David Lane, of "Using antibodies: a laboratory manual." (1999). Dr. Harlow has trained scientists in the field of molecular biology and oncology, including Nicholas Dyson (Professor at

and Scientific Director of the

Cancer Center), Jacqueline Lees (Professor of Biology at

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the mo ...

and associate director of the Koch Institute), Joshua LaBaer (Virginia G. Piper Chair in Personalized Medicine at

Arizona State University Arizona State University (Arizona State or ASU) is a public research university in the Phoenix metropolitan area. Founded in 1885 by the 13th Arizona Territorial Legislature, ASU is one of the largest public universities by enrollment in the ...

and Director of the Biodesign Institute), Matthew Meyerson (Professor of Pathology at the

and

and Senior Associate Member of the

Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, U ...

Li-Huei Tsai Li-Huei Tsai () is a neuroscientist and the director of the Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology. She is known for her work on neurological diso ...

(Picower Professor of Neuroscience at

and Director of the Picower Center for Learning and Memory), and Marc Vidal (Director of the Center for Cancer Systems Biology at the

Publications

*Dyson, Nicholas, et al. "The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product." Science 243.4893 (1989): 934–937. *Whyte, Peter, et al. "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product." (1988): 124–129. *LaBaer, Joshua, et al. "New functional activities for the p21 family of CDK inhibitors." Genes & development 11.7 (1997): 847–862. *Buchkovich, Karen, Linda A. Duffy, and Ed Harlow. "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097–1105. *van den Heuvel, Sander, and Ed Harlow. "Distinct roles for cyclin-dependent kinases in cell cycle control." Science 262.5142 (1993): 2050–2054. *Harlow, E. D., et al. "Monoclonal antibodies specific for simian virus 40 tumor antigens." Journal of Virology 39.3 (1981): 861–869. *Tsai, Li-Huei, et al. "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5." (1994): 419–423. *Meyerson, Matthew, et al. "A family of human cdc2-related protein kinases." The EMBO Journal 11.8 (1992): 2909. *Whyte, Peter, Nicola M. Williamson, and E. D. Harlow. "Cellular targets for transformation by the adenovirus E1A proteins." cell 56.1 (1989): 67–75.

Awards

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

, Member *

Alfred P. Sloan, Jr. Prize The Alfred P. Sloan Jr. Prize was a $250,000 award given by the General Motors Cancer Research Foundation for outstanding oncological research. The prize was awarded annually from 1979 to 2005. Of the winners, 15 out of 37 have gone on to win eith ...

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

, Member *

Dickson Prize The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsburg ...

in Medicine *

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

, Member *

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...

, Medal of Honor

References

{{DEFAULTSORT:Harlow, Ed 1952 births Living people American molecular biologists Harvard Medical School faculty Members of the National Academy of Medicine