Transcription factor binding sites
NT5E contains binding sites for transcription factors AP-2, SMAD proteins, SP-1 and elements responsive to c-AMP , which can be found in c-AMP promoter parts. SMADs 2, 3, 4 and 5 and SP-1 are binding to the NT5E promoter in rats, as was proven in chromatin immunoprecipitation assays. Due to the fact, that the human and rat NT5E transcripts are 89% identical, human NT5E could be also regulated by SMAD proteins.Function
Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate beingImmunosuppression
NT5E (CD73) is a surfaceAs a drug target
Some tumours have upregulation and overexpression of CD73 so it has been proposed as a drug target for cancer therapy. An anti-CD73 antibody CPI-006 has started early stageSystemic lupus erythematosus
Specialized immune cells such as myeloid-derived suppressor cells and regulatory T cells also mediate their effects via adenosine generated by local ectonucleotidase. In some cases of lupus patients, adequate T cell expression of CD73 is missing, which shows an impaired regulatory function of T cells.Cancer
NT5E can act as an immune inhibitory control molecule. Free adenosine generated by NT5E inhibits cellular immune responses and thereby promotes immune escape of tumor cells. Due to enzymatic and non-enzymatic properties, CD73 is involved in cancer-related processes and is upregulated in many cancers such asmiRNA
MicroRNA are small non-codingSee also
* Cluster of differentiation * Arterial calcification due to CD73 deficiencyReferences
Further reading
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* * {{Clusters of differentiation Clusters of differentiation