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Earl Wilbur Sutherland Jr. (November 19, 1915 – March 9, 1974) was an American
pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
and biochemist born in
Burlingame, Kansas Burlingame is a city in Osage County, Kansas, United States. As of the 2020 census, the population of the city was 971. History Burlingame was originally established as Council City and was an stop on the Santa Fe Trail. The Council City po ...
. Sutherland won a
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially
epinephrine Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and ...
, via
second messengers Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form or cell signaling, encompassing both first me ...
, namely
cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transd ...
, or cyclic AMP.


Early life

Sutherland was born on November 19, 1915, in Burlingame,
Kansas Kansas () is a state in the Midwestern United States. Its capital is Topeka, and its largest city is Wichita. Kansas is a landlocked state bordered by Nebraska to the north; Missouri to the east; Oklahoma to the south; and Colorado to the ...
. The second youngest of six children, he was raised by his mother, Edith M. Hartshorn, and his father, Earl W. Sutherland.Gale Group (2006)
“World of Scientific Discovery on Earl Sutherland”
World of Scientific Discovery.
Though his father, who was originally from
Wisconsin Wisconsin () is a state in the upper Midwestern United States. Wisconsin is the 25th-largest state by total area and the 20th-most populous. It is bordered by Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake M ...
, had attended
Grinnell College Grinnell College is a private liberal arts college in Grinnell, Iowa, United States. It was founded in 1846 when a group of New England Congregationalists established the Trustees of Iowa College. Grinnell has the fifth highest endowment-to-st ...
for two years, he ultimately led an agrarian lifestyle that took him to both
New Mexico ) , population_demonym = New Mexican ( es, Neomexicano, Neomejicano, Nuevo Mexicano) , seat = Santa Fe , LargestCity = Albuquerque , LargestMetro = Tiguex , OfficialLang = None , Languages = English, Spanish ( New Mexican), Navajo, Ker ...
and
Oklahoma Oklahoma (; Choctaw language, Choctaw: ; chr, ᎣᎧᎳᎰᎹ, ''Okalahoma'' ) is a U.S. state, state in the South Central United States, South Central region of the United States, bordered by Texas on the south and west, Kansas on the nor ...
before settling down in Burlingame to raise a family. Edith, a
Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ...
native, had some training in nursing at what was called a "ladies college". To provide for the family, Sutherland's father ran a dry goods store, where he gave each of his children working jobs. Sutherland began fishing at the age of five, and this became a pastime that he enjoyed for most of his life.


Education

As a high school student, Sutherland played and excelled in several sports, including
tennis Tennis is a racket sport that is played either individually against a single opponent ( singles) or between two teams of two players each ( doubles). Each player uses a tennis racket that is strung with cord to strike a hollow rubber ball ...
,
basketball Basketball is a team sport in which two teams, most commonly of five players each, opposing one another on a rectangular Basketball court, court, compete with the primary objective of #Shooting, shooting a basketball (ball), basketball (appr ...
, and
football Football is a family of team sports that involve, to varying degrees, kicking a ball to score a goal. Unqualified, the word ''football'' normally means the form of football that is the most popular where the word is used. Sports commonly c ...
."Earl Sutherland Biography"
BookRags.com
In 1933, at the age of 17, Sutherland enrolled in
Washburn College Washburn University (WU) is a public university in Topeka, Kansas, United States. It offers undergraduate and graduate programs, as well as professional programs in law and business. Washburn has 550 faculty members, who teach more than 6,100 u ...
, a school located in
Topeka Topeka ( ; Kansa: ; iow, Dópikˀe, script=Latn or ) is the capital city of the U.S. state of Kansas and the seat of Shawnee County. It is along the Kansas River in the central part of Shawnee County, in northeast Kansas, in the Central Un ...
, Kansas and began the pursuit of a
Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...
degree. In order to pay for tuition, he worked throughout his undergraduate years as a medical staff assistant at a local hospital. Sutherland graduated in 1937, at the age of 21. He was then accepted to
Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or ...
in
St. Louis, Missouri St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi River, Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the Greater St. Louis, ...
, where he developed a strong
mentorship Mentorship is the influence, guidance, or direction given by a mentor. A mentor is someone who teaches or gives help and advice to a less experienced and often younger person. In an organizational setting, a mentor influences the personal and p ...
with
Carl Ferdinand Cori Carl Ferdinand Cori, ForMemRS (December 5, 1896 – October 20, 1984) was an Austrian-American biochemist and pharmacologist born in Prague (then in Austria-Hungary, now Czech Republic) who, together with his wife Gerty Cori and Argentine physio ...
. In 1942, Sutherland graduated with a
Doctor of Medicine Doctor of Medicine (abbreviated M.D., from the Latin language, Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a profes ...
.


Career


Academia and research

In 1940, while studying at the Washington University School of Medicine, Sutherland had his first encounter with research as an assistant in
pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
in the laboratory of Carl Ferdinand Cori, who won a
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
in 1947 for his discovery of the mechanism of
glycogen Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. The polysaccharide structure represents the main storage form of glucose in the body. Glycogen functions as one o ...
metabolism.Sutherland, Earl W (December 11, 1971)
"Studies on the Mechanism of Hormone Action"
Nobel Lecture.
"The Nobel Prize in Physiology or Medicine 1947."
Nobelprize.org.
Under Cori's guidance, Sutherland conducted research on the effects of the hormones
epinephrine Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and ...
and
glucagon Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises concentration of glucose and fatty acids in the bloodstream, and is considered to be the main catabolic hormone of the body. It is also used as a Glucagon (medicati ...
on the breakdown of glycogen to glucose. In 1942, he worked as an intern at Washington University's Barnes Hospital."Earl W. Sutherland Jr. – Curriculum Vitae."
Nobelprize.org.
After receiving his medical degree from Washington University in 1942, Sutherland served as a
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
army physician. He returned to Washington University in 1945, where he continued to do research in Cori's Laboratory. Sutherland accredits his decision to pursue a research career, as opposed to entering the medical profession, to his mentor Cori. Sutherland held various teaching titles during his time at the Washington University School of Medicine, including instructor in pharmacology (1945–46), instructor in
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
(1946–50), assistant professor in biochemistry (1950–52), and associate professor in biochemistry (1952–53). In 1953, Sutherland moved to
Cleveland Cleveland ( ), officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in the northeastern part of the state, it is situated along the southern shore of Lake Erie, across the U.S. ...
,
Ohio Ohio () is a state in the Midwestern region of the United States. Of the fifty U.S. states, it is the 34th-largest by area, and with a population of nearly 11.8 million, is the seventh-most populous and tenth-most densely populated. The sta ...
for a position as a professor of pharmacology and chairman of the department of pharmacology at the school of medicine at
Case Western Reserve University Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reser ...
(formerly, Western Reserve University). There, he collaborated with Theodore W. Rall, also a professor of pharmacology, who was to become a lifelong research partner. Together, they conducted further research on the mechanism of hormone action at the molecular level. During his ten years at Case Western Reserve University, Sutherland made several ground-breaking discoveries that led to the identification of
cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transd ...
, or cyclic AMP, and its role as a
secondary messenger Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form or cell signaling, encompassing both first me ...
. In 1963, Sutherland became professor of anatomy at
Vanderbilt University School of Medicine Vanderbilt University School of Medicine is a graduate medical school of Vanderbilt University located in Nashville, Tennessee. Located in the Vanderbilt University Medical Center on the southeastern side of the Vanderbilt University campus, the S ...
in
Nashville Nashville is the capital city of the U.S. state of Tennessee and the seat of Davidson County. With a population of 689,447 at the 2020 U.S. census, Nashville is the most populous city in the state, 21st most-populous city in the U.S., and the ...
,
Tennessee Tennessee ( , ), officially the State of Tennessee, is a landlocked state in the Southeastern region of the United States. Tennessee is the 36th-largest by area and the 15th-most populous of the 50 states. It is bordered by Kentucky to th ...
. His position allowed him to devote more time to his research. He continued his work on cyclic AMP, receiving financial support from the Career Investigatorship awarded to him by the
American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...
in 1967. He held his teaching title at
Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...
until 1973.


Discovery of cyclic AMP

While working in Cori's laboratory, Sutherland, with the help of his co-workers, made several discoveries concerning the mechanism of
glycogen Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, fungi, and bacteria. The polysaccharide structure represents the main storage form of glucose in the body. Glycogen functions as one o ...
metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...
that, years later, led him to his discovery of the biological activity of cyclic AMP. Cori's laboratory had previously established the basic mechanism of glycogen metabolism, for which they were awarded the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
. Sutherland helped to identify the importance of liver phosphorylase (LP) in the process of
glycogenolysis Glycogenolysis is the breakdown of glycogen (n) to glucose-1-phosphate and glycogen (n-1). Glycogen branches are catabolized by the sequential removal of glucose monomers via phosphorolysis, by the enzyme glycogen phosphorylase. Mechanism The ...
. Of the three basic
enzymes Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
involved in glycogenolysis, he found that LP was rate-limiting, meaning that the progression of glycogen metabolism is dependent on this enzyme. LP would become the subject of his research for the next several years, and it was through experimentation on LP and
hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...
interaction that his most renowned discovery was made. After identifying the importance of LP, Sutherland moved his research efforts to Western Reserve University. There, he worked in collaboration with Ted Rall, Walter D Wosilait, and Jacques Berthet to publish a series of papers in the ''Journal of Biological Chemistry'' titled "The Relationship of Epinephrine and Glucagon to Liver Phosphorylase", in four parts. These four papers document the purification of LP and the analysis of several of its properties. First, it was determined that the enzymatic activity of LP depends on the addition or removal of a
phosphate In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid . The phosphate or orthophosphate ion is derived from phospho ...
group, a process called
phosphorylation In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
. In a later experiment, they demonstrated that more phosphate is taken up in liver slices when epinephrine and glucagon are added, suggesting that these hormones were promoting the phosphorylation of LP, activating the enzyme. The results of a later paper in the series suggested that this phosphorylation and activation of LP was a result of the action of phosphorlyase
kinase In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule don ...
. This series also investigated the inactivation of liver phosphorylase and characterized an enzyme they initially called LP-inactivating enzyme, which functions by cleaving the phosphate group. This enzyme was later renamed liver phosphorylase phosphatase. These papers also characterized LP in terms of molecular weight and other factors. During their analysis, they found the unexpected result that LP activation increased with the addition of 5-AMP, which is a precursor of cAMP; however, this was not known at the time. The fourth paper published in this series, entitled "The Relationship of Epinephrine and Glucagon to Liver Phosphorylase: IV Effect of Epinephrine and Glucagon on the Reactivation of Phosphorylase in Liver Homogenates", came out in 1956 and was the most influential and groundbreaking of those released. In this paper, Sutherland and associates furthered their investigation of epinephrine and glucagon. The key to the success of this experiment was the use a
homogenate Homogeneity and heterogeneity are concepts often used in the sciences and statistics relating to the uniformity of a substance or organism. A material or image that is homogeneous is uniform in composition or character (i.e. color, shape, s ...
of liver cells rather than intact liver cells, as they had been doing in their previous experiments. The general consensus among researchers at that time was that the study of hormones was only possible using intact cells; this was the first instance that a hormone pathway was studied using a cell homogenate. Sutherland and his co-authors were able to observe similar effects in liver homogenate to what was observed in whole liver slices. More importantly, they were able to observe this response in two stages. This stage response was characterized by the particulate fraction producing an unknown heat stable factor in the presence of the hormones epinephrine and glucagon. This factor then stimulates the formation of liver phosphorylase in a fraction of the homogenate where the hormones are not present. This unknown heat stable factor, which was produced in the presence of hormones and ultimately led to the secondary formation of liver phosphorylase, was later termed cyclic AMP. Even though the discovery of cyclic AMP and the idea of
second messengers Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a non-local form or cell signaling, encompassing both first me ...
were of great importance to the world of medicine, Sutherland's findings were actually achieved through strenuous trial and error. First of all, Sutherland and Ted Rall were convinced that a
sucrose Sucrose, a disaccharide, is a sugar composed of glucose and fructose subunits. It is produced naturally in plants and is the main constituent of white sugar. It has the molecular formula . For human consumption, sucrose is extracted and refined ...
homogenate of liver cells was absolutely necessary in order to keep their cells healthy and proliferating. This inference was made by Rall from his experience studying
mitochondria A mitochondrion (; ) is an organelle found in the Cell (biology), cells of most Eukaryotes, such as animals, plants and Fungus, fungi. Mitochondria have a double lipid bilayer, membrane structure and use aerobic respiration to generate adenosi ...
, which responded well to these sucrose homogenates; however, it had nothing to do with what was being studied at the time. It turned out that this sucrose was not necessary for the homogenate and once they set up the experiment without sucrose they were able to see more effective results. Secondly, Sutherland initially believed that there was something vital about the intact cell, and that disrupting its structure would not produce any hormonal effect. However, after some debate, Rall had convinced Sutherland to use liver homogenates. Once they had witnessed nearly a doubling of the rate of LP activation, they knew this belief in that keeping cells intact was crucial to studying the effects of hormones was not necessarily true, at least in this case. Finally, Sutherland had decided to ignore Jacques Berthet's request to conduct the same experiment using proper lab technique, specifically the Lehninger Hard Pour, where the supernatant material was decanted by pouring the liquid into another test tube once the particulate fraction reached the top of the original tube. Berthet not only demanded this step of the procedure be done through careful aspiration, he also critiqued the lack of specificity during centrifugation with respect to suspension height, rpm and time. The willingness of Sutherland and his associates to modify their experimental procedures and mistaken assumptions allowed them to make the discoveries that they made.


Personal life

Sutherland married Mildred Rice in 1937, the same year that he graduated from
Washburn College Washburn University (WU) is a public university in Topeka, Kansas, United States. It offers undergraduate and graduate programs, as well as professional programs in law and business. Washburn has 550 faculty members, who teach more than 6,100 u ...
. In 1944, during
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
, Sutherland was called into service as a battalion surgeon under General George S. Patton, and was later sent to
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
, where he served as a staff physician in a military hospital until 1945."Earl W. Sutherland Jr. – Biography."
Louis Calder Memorial Library.
He had two sons and a daughter with Mildred Rice. In 1962, Sutherland divorced his first wife. A year later, when he became professor of physiology at
Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...
, Sutherland married Dr. Claudia Sebeste Smith, the assistant dean at the university and they were together for the remainder of Sutherland's life.


Awards and achievements

* 1937 – Bachelor of Science from
Washburn College Washburn University (WU) is a public university in Topeka, Kansas, United States. It offers undergraduate and graduate programs, as well as professional programs in law and business. Washburn has 550 faculty members, who teach more than 6,100 u ...
in
Topeka, Kansas Topeka ( ; Kansa language, Kansa: ; iow, Dópikˀe, script=Latn or ) is the Capital (political), capital city of the U.S. state of Kansas and the County seat, seat of Shawnee County, Kansas, Shawnee County. It is along the Kansas River in the ...
; * 1942 – Doctor of medicine from
Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or ...
in
St. Louis, Missouri St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi River, Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the Greater St. Louis, ...
; * 1969 – Torald Sollman Award in Pharmacology ,
Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...
; * 1970 –
Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...
; * 1971 –
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
, Achievement Award from the American Heart Association; * 1971 – Golden Plate Award of the
American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet o ...
; * 1973 –
National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...
awarded by Richard Nixon. In 1952, Sutherland was awarded the Banting Memorial Lectureship and, in 1953, was elected as the Chairman of the Case Western Reserve University Department of Pharmacology in Cleveland, Ohio. He was awarded the Career Investigator position at the
American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...
in 1967 and was elected as member of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
in 1973. Sutherland was also a member of various scientific societies which included the American Society of Biological Chemists, the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
, the
American Society for Pharmacology and Experimental Therapeutics The American Society for Pharmacology and Experimental Therapeutics (ASPET) is a scientific society founded in late 1908 by John Jacob Abel of Johns Hopkins University (also the founder of the American Society for Biochemistry and Molecular Biol ...
, the
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
, and
Sigma Xi Sigma Xi, The Scientific Research Honor Society () is a highly prestigious, non-profit honor society for scientists and engineers. Sigma Xi was founded at Cornell University by a junior faculty member and a small group of graduate students in 1886 ...
. From 1951 to 1956, Sutherland was a member of the editorial board for the Biochemical Preparations Journal. The editorial board of the
Journal of Pharmacology and Experimental Therapeutics The ''Journal of Pharmacology and Experimental Therapeutics'' (a.k.a. JPET) is a peer-reviewed scientific journal covering pharmacology. It has been published since 1909 by the American Society for Pharmacology and Experimental Therapeutics (ASPET) ...
sought is attention from 1957 to 1958. In 1973, after spending 10 years at
Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...
, Sutherland moved to
Miami Miami ( ), officially the City of Miami, known as "the 305", "The Magic City", and "Gateway to the Americas", is a East Coast of the United States, coastal metropolis and the County seat, county seat of Miami-Dade County, Florida, Miami-Dade C ...
,
Florida Florida is a state located in the Southeastern region of the United States. Florida is bordered to the west by the Gulf of Mexico, to the northwest by Alabama, to the north by Georgia, to the east by the Bahamas and Atlantic Ocean, and to ...
, where he joined the faculty at the
University of Miami The University of Miami (UM, UMiami, Miami, U of M, and The U) is a private research university in Coral Gables, Florida. , the university enrolled 19,096 students in 12 colleges and schools across nearly 350 academic majors and programs, incl ...
's
Leonard M. Miller School of Medicine Leonard M. Miller School of Medicine (UMMSM) is the University of Miami's graduate medical school in Miami, Florida. Founded in 1952, it is the oldest medical school in the state of Florida. Campus The University of Miami's Leonard M. Miller Sch ...
as a distinguished professor of biochemistry. He continued to be involved in novel research about
adenosine monophosphate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine; it is an ester of phosphoric acid and the nucleoside adenosine. As a substituent it t ...
and
guanosine monophosphate Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside guanosine. GMP consists of the ...
, co-authoring four papers in 1973 alone."Earl W. Sutherland Jr. – Additional Publications."
Louis Calder Memorial Library.


Death

On March 9, 1974, Sutherland died of internal bleeding due to surgical complications after suffering a massive esophageal
hemorrhage Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vag ...
. He was 58 years old.


Legacy

After Sutherland's death, in 1974, the University of Miami's Leonard M. Miller School of Medicine established the Sutherland Memorial Lecture. In 1976, Vanderbilt University created the Sutherland Prize which is awarded annually to a faculty member whose work has garnered them national, if not international, acclaim and respect. Recipients are awarded $5,000, and their name is engraved on a silver bowl."Earl Sutherland Prize for Achievement in Research"
Vanderbilt University, Nashville, Tennessee.
Vanderbilt honored Sutherland in 1997 by starting a Sutherland lecture, and again in 2001 in the creation of the Sutherland Chair of Pharmacology. Heidi E. Hamm, a member of the Vanderbilt faculty, was appointed to this position upon its establishment and still maintains this title.Macmillan, Leigh (May 18, 2001

Vanderbilt University Medical Center.


References


External links

*
Lasker linkNAS link
{{DEFAULTSORT:Sutherland, Earl Wilbur Jr. 1915 births 1974 deaths American Nobel laureates American physiologists Case Western Reserve University faculty National Medal of Science laureates Nobel laureates in Physiology or Medicine People from Burlingame, Kansas American pharmacologists Recipients of the Albert Lasker Award for Basic Medical Research University of Miami faculty Vanderbilt University faculty Washington University School of Medicine alumni Nobel laureates affiliated with Missouri Members of the United States National Academy of Sciences Washburn University alumni Washington University in St. Louis alumni Washington University School of Medicine faculty Washington University in St. Louis faculty