EXE4

Eoxin E4, also known as 14,15-

leukotriene E4 Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including eosinophils, mast cells, tissue macrophages, and basophils, and recently was also found to be pr ...

, is an

eoxin Eoxins are proposed to be a family of proinflammatory eicosanoids (signaling compounds that regulate inflammatory and immune responses). They are produced by human eosinophils (a class of white blood cells), mast cells, the L1236 Reed–Sternberg ...

. Cells make eoxins by metabolizing

arachidonic acid Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). It is structurally related to the saturated arachidic acid found in cupuaçu butter. Its name derives from the New Latin word ''arachi ...

with a 15-lipoxygenase enzyme to form 15(''S'')-hydroperoxyeicosapentaenoic acid (i.e. 15(''S'')-HpETE). This product is then converted serially to eoxin A4 (i.e.

EXA4 Eoxin A4, also known as 14,15-leukotriene A4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(''S'')-hydroperoxyeicosapentaenoic acid (i.e. 15(''S'')-HpETE). This product is then converted ...

), EXC4,

EXD4 Eoxin D4, also known as 14,15-leukotriene D4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15-Hydroxyeicosatetraenoic acid, 15(''S'')-hydroperoxyeicosapentaenoic acid (i.e. 15(''S'')-HpETE). ...

, and

EXE4 Eoxin E4, also known as 14,15-leukotriene E4, is an eoxin. Cells make eoxins by metabolizing arachidonic acid with a 15-lipoxygenase enzyme to form 15(''S'')-hydroperoxyeicosapentaenoic acid (i.e. 15(''S'')-HpETE). This product is then converte ...

LTC4 synthase Leukotriene C4 synthase is an enzyme that in humans is encoded by the ''LTC4S'' gene. The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. Th ...

, an unidentified

gamma-glutamyltransferase Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; ) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to ...

, and an unidentified

dipeptidase Dipeptidases are enzymes secreted by enterocytes into the small intestine. Dipeptidases hydrolyze bound pairs of amino acids, called dipeptides. Dipeptidases are secreted onto the brush border of the villi in the small intestine, where they cleave ...