Epsin-1 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''EPN1''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles. upplied by OMIMref name="entrez" />

Interactions

EPN1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

REPS2 RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the ''REPS2'' gene. Function The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The en ...

AP2A2 AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the ''AP2A2'' gene. Interactions AP2A2 has been shown to interact with EPN1 and SHC1 SHC-transforming protein 1 is a protein that in humans is encoded by the ''SHC1'' gen ...

and

EPS15 Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the ''EPS15'' gene. Function This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved i ...

Interactions

References

Further reading