Eukaryotic translation initiation factor 4 gamma 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''EIF4G1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The protein encoded by this gene is a component of the protein complex
eIF4F
Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to promote eukaryotic translation initiation. The eIF4F complex is composed of three non-identical subunits: the DEAD- ...
, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.
eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the
PABP and
eIF3
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential for most forms of Eukaryotic translation#Cap-dependent initiation, cap-dependent and Eukaryotic t ...
.
Interactions
Eukaryotic translation initiation factor 4 gamma has been shown to
interact
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with
MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the ''MKNK1'' gene.
Interactions
MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma
Eukaryotic trans ...
,
EIF4A1
Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the ''EIF4A1'' gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-depe ...
,
EIF4E
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the ''EIF4E'' gene.
Structure and function
Most eukaryotic cellular mRNAs are blocked at their 5'-ends with the 7-methyl-guanosine fi ...
,
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''MKNK2'' gene.
Interactions
MKNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma
Eukaryotic trans ...
PABPC1
Polyadenylate-binding protein 1 is a protein that in humans is encoded by the ''PABPC1'' gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stabili ...
.
See also
*Eukaryotic initiation factor Eukaryotic initiation factors (eIFs) are Protein, proteins or Protein complex, protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the ...
References
Further reading
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{{Initiation factors