Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''EIF3A''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

Interactions

EIF3A has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: * DISC1, *

EIF3B Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the ''EIF3B'' gene. Interactions EIF3B has been shown to interact with P70-S6 Kinase 1 and EIF3A Eukaryotic translation initiation factor ...

, *

EIF3C Eukaryotic translation initiation factor 3 subunit C (eIF3c) is a protein that in humans is encoded by the ''EIF3C'' gene. Interactions EIF3C has been shown to interact with EIF3G and EIF3A Eukaryotic translation initiation factor 3 subunit ...

, *

EIF3D Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the ''EIF3D'' gene. Function Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed ...

, *

EIF3EIP Eukaryotic translation initiation factor 3 subunit L (eIF3l), less commonly known as EIF3EIP, is a protein that in humans is encoded by the ''EIF3L'' gene. Interactions eIF3l has been shown to Protein-protein interaction, interact with EIF3A, e ...

, *

EIF3F Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the ''EIF3F'' gene. Interactions EIF3F has been shown to interact with Mammalian target of rapamycin and EIF3A Eukaryotic translation initi ...

, * EIF3G, *

EIF3H Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the ''EIF3H'' gene. Interactions eIF3h has been shown to interact with eIF3a Eukaryotic translation initiation factor 3 subunit A (eIF3a) ...

, *

EIF3I Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the ''EIF3I'' gene. Interactions eIF3i has been shown to interact with TGF beta 1 and eIF3a Eukaryotic translation initiation factor 3 sub ...

EIF3J Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the ''EIF3J'' gene. Interactions eIF3j has been shown to interact with eIF3a Eukaryotic translation initiation factor 3 subunit A (eIF3a) i ...

, *

EIF3K Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the ''EIF3K'' gene. Function The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, inclu ...

, *

EIF3S6 Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the ''EIF3E'' gene. Interactions EIF3S6 has been shown to interact with: * BAT2, * COPS6 * CSN3, * EIF3A Eukaryotic translation initia ...

, *

EIF4B Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the ''EIF4B'' gene. Interactions eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subu ...

, * EIF4G2, and *

FBXO32 F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the ''FBXO32'' gene. Function This gene encodes a member of the F-box protein family which is characteriz ...

Interactions

See also

References

Further reading