Doris Tsao
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Doris Ying Tsao is an American systems neuroscientist and professor of biology at the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...
. She was formerly on the faculty at the
California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
. She is recognized for pioneering the use of
fMRI Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area ...
with single-unit electrophysiological recordings and for discovering the macaque face patch system for
face perception Facial perception is an individual's understanding and interpretation of the face. Here, perception implies the presence of consciousness and hence excludes automated facial recognition systems. Although facial recognition is found in other sp ...
. She is a Howard Hughes Medical Institute Investigator and the director of the T&C Chen Center for Systems Neuroscience. She won a MacArthur "Genius" fellowship in 2018. Tsao was elected a member of the National Academy of Sciences in 2020.


Early life and education

Tsao was born in Changzhou, China before her family immigrated to the United States when she was four. She grew up in
College Park, Maryland College Park is a city in Prince George's County, Maryland, United States, and is approximately four miles (6.4 km) from the northeast border of Washington, D.C. The population was 34,740 at the 2020 United States Census. It is best known ...
and attended Springbrook High School. Her interest in science and in visual neuroscience in particular was inspired by her father, a
machine vision Machine vision (MV) is the technology and methods used to provide imaging-based automatic inspection and analysis for such applications as automatic inspection, process control, and robot guidance, usually in industry. Machine vision refers to ...
researcher. She completed her B.S. in biology and mathematics in just three years at
Caltech The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
in 1996. She then worked with
Margaret Livingstone Margaret Stratford Livingstone is the Takeda Professor of Neurobiology in the Department of Neurobiology at Harvard Medical School in the field of visual perception. She authored the book ''Vision and Art: The Biology of Seeing''. She was elect ...
at the
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
, where she received her PhD in 2002 and continued to work as a postdoctoral fellow. In 2004 she received the
Sofia Kovalevskaya Award The Alexander von Humboldt Foundation of Germany bestows the Sofia Kovalevskaya Award every two years. Sofia Kovalevskaya (1850–1891) was the first major Russian female mathematician, who made important contributions to mathematical analysis, ...
from the
Humboldt Foundation The Alexander von Humboldt Foundation (german: Alexander von Humboldt-Stiftung) is a foundation established by the government of the Federal Republic of Germany and funded by the Federal Foreign Office, the Federal Ministry of Education and Resea ...
, which allowed her to start her own independent research group at the
University of Bremen The University of Bremen (German: ''Universität Bremen'') is a public university in Bremen, Germany, with approximately 23,500 people from 115 countries. It is one of 11 institutions which were successful in the category "Institutional Strategi ...
in Germany in 2006. In 2009 she joined the faculty at
Caltech The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
.


Career and research

As a PhD student working with
Margaret Livingstone Margaret Stratford Livingstone is the Takeda Professor of Neurobiology in the Department of Neurobiology at Harvard Medical School in the field of visual perception. She authored the book ''Vision and Art: The Biology of Seeing''. She was elect ...
, Tsao began by studying
stereopsis Stereopsis () is the component of depth perception retrieved through binocular vision. Stereopsis is not the only contributor to depth perception, but it is a major one. Binocular vision happens because each eye receives a different image becaus ...
in macaques using single-unit electrophysiological recordings. She then became interested in using fMRI, a technique usually used to visualize the activity of brain areas in humans, to image brain regions in macaques. She collaborated with Roger Tootell to use
fMRI Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area ...
to image brain regions involved in depth perception, and then collaborated with Winrich Freiwald, a postdoctoral fellow working with
Nancy Kanwisher Nancy Gail Kanwisher FBA (born 1958) is the Ellen Swallow Richards Professor in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology and an investigator at the McGovern Institute for Brain Research. She s ...
at
MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ...
, to combine single-unit electrophysiology with fMRI to study
face perception Facial perception is an individual's understanding and interpretation of the face. Here, perception implies the presence of consciousness and hence excludes automated facial recognition systems. Although facial recognition is found in other sp ...
in macaques. Similar to the
fusiform face area The fusiform face area (FFA, meaning spindle-shaped face area) is a part of the human visual system (while also activated in people blind from birth) that is specialized for facial recognition. It is located in the inferior temporal cortex ( ...
identified in humans with, they discovered a series of small brain areas, referred to as the macaque face patch system, that contain neurons which are selectively activated by faces. Tsao and her lab have continued to make significant advances in understanding the specific facial features that cause neurons in these face patches to be activated. In 2017, her lab "cracked the code" of how our brains recognize faces, identifying the feature dimensions that cause face-selective neurons in different face patches of the IT cortex to respond to faces. Thus, the images of faces presented to the monkeys could be precisely reconstructed from face-selective neurons' activity. Tsao was named in
MIT Technology Review ''MIT Technology Review'' is a bimonthly magazine wholly owned by the Massachusetts Institute of Technology, and editorially independent of the university. It was founded in 1899 as ''The Technology Review'', and was re-launched without "The" in ...
's
TR35 The Innovators Under 35 is a peer-reviewed annual award and listicle published by ''MIT Technology Review'' magazine, naming the world's top 35 innovators under the age of 35. at ''Technology Review'' with lists of winners at technologyreview.com ...
list in 2007. She is serving on the Advisory Committee to the NIH Director (BRAIN Initiative Working Group 2.0) established in 2018, the group that advises on allocation of $1.511 billion toward neuroscience research.


See also

*
List of neuroscientists Many famous neuroscientists are from the 20th and 21st century, as neuroscience is a fairly new science. However many anatomists, physiologists, biologists, neurologists, psychiatrists and other physicians and psychologists are considered to be n ...


References


External links


Caltech Neuroscience
* {{DEFAULTSORT:Tsao, Doris Living people California Institute of Technology alumni American people of Chinese descent Educators from Changzhou Harvard University alumni American neuroscientists American women neuroscientists California Institute of Technology faculty Howard Hughes Medical Investigators MacArthur Fellows Year of birth missing (living people) Scientists from Changzhou Members of the United States National Academy of Sciences American women academics 21st-century American women