Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major
protein domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...
of many
blood coagulation factors.
Blood coagulation factors
V and
VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to the
C2 domain
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 beta sheet, β-strands that co-ordinates two or three calcium ions, which bind in a cavity ...
). In the ''
Dictyostelium discoideum
''Dictyostelium discoideum'' is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. Commonly referred to as slime mold, ''D. discoideum'' is a eukaryote that transitions from a collection of unicellular ...
'' (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins.
In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells.
The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity.
FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond.
A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM .
Human proteins containing this domain
AEBP1;
BTBD9;
CASPR4;
CNTNAP1
CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene.
CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane pr ...
;
CNTNAP2
Contactin-associated protein-like 2 is a protein that in humans is encoded by the ''CNTNAP2'' gene. Since the most recent reference human genome GRCh38, CNTNAP2 is the longest gene in the human genome
This gene encodes a member of the neurexin fa ...
;
CNTNAP3;
CNTNAP4
Contactin-associated protein-like 4 is a protein that in humans is encoded by the ''CNTNAP4'' gene.
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and recept ...
;
CNTNAP5;
CPXM1;
CPXM2;
DCBLD1;
DCBLD2
Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the ''DCBLD2'' gene.
Model organisms
Model organisms have been used in the study of DCBLD2 function. A conditional knockout mouse line called ''Dcbld2tm ...
;
DDR1
Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.
Function
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. ...
;
DDR2;
EDIL3
EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''ge ...
;
F5;
F8;
F8B;
MFGE8
Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the ''MFGE8'' gene.
Species distribution
Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds.
...
;
NRP1
Neuropilin-1 is a protein that in humans is encoded by the ''NRP1'' gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.
Function
NRP1 is a membrane-bound coreceptor to a tyrosine kinase rece ...
;
NRP2
Neuropilin 2 (NRP2) is a protein that in humans is encoded by the ''NRP2'' gene.
This gene encodes a member of the neuropilin
Neuropilin is a protein receptor active in neurons.
There are two forms of Neuropilins, NRP-1 and NRP-2. Neuropili ...
;
RS1;
SSPO;
UNC13A
Unc-13 homolog A (''C. elegans'') is a protein that in humans is encoded by the UNC13A gene.
Function
This gene encodes a member of the UNC13 family. UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycero ...
References
;Notes
Further reading
{{DEFAULTSORT:Discoidin Domain
Protein domains
Single-pass transmembrane proteins