''Dichroa febrifuga'' is a

flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...

in the family

Hydrangeaceae Hydrangeaceae is a family of flowering plants in the order Cornales, with a wide distribution in Asia and North America, and locally in southeastern Europe. Description The genera are characterised by leaves in opposite pairs (rarely whorled ...

National names

* Chinese: ) *

Indonesian language Indonesian ( ) is the official language, official and national language of Indonesia. It is a standard language, standardized variety (linguistics), variety of Malay language, Malay, an Austronesian languages, Austronesian language that has be ...

: ''gigil'', alternatively ''tataruman'' *

Sundanese Sundanese may refer to: * Sundanese people * Sundanese language * Sundanese script Standard Sundanese script (''Aksara Sunda Baku'', ) is a writing system which is used by the Sundanese people. It is built based on Old Sundanese script (' ...

: ''ramram'' * Papua: ''Hom dong'' (ฮอมดง): *

Thai Thai or THAI may refer to: * Of or from Thailand, a country in Southeast Asia ** Thai people, the dominant ethnic group of Thailand ** Thai language, a Tai-Kadai language spoken mainly in and around Thailand *** Thai script *** Thai (Unicode block ...

: ''Yai khlang yai'' (ยายคลังใหญ่), in Nakhon Sri Thammarat, Yai Krang (ยายกรัง) in the South, and ''Hom Kham'' (ฮอมคำ) in

Lanna The Lan Na Kingdom ( nod, , , "Kingdom of a Million Rice Fields"; th, อาณาจักรล้านนา, , ), also known as Lannathai, and most commonly called Lanna or Lanna Kingdom, was an Indianized state centered in present-day ...

(Northern Thai).

Traditional Chinese medicine

''Dichroa febrifuga'' is an important

herb In general use, herbs are a widely distributed and widespread group of plants, excluding vegetables and other plants consumed for macronutrients, with savory or aromatic properties that are used for flavoring and garnishing food, for medicinal ...

traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action ...

, where it is considered one of the

50 fundamental herbs Chinese herbology () is the theory of traditional Chinese herbal therapy, which accounts for the majority of treatments in traditional Chinese medicine (TCM). A ''Nature'' editorial described TCM as "fraught with pseudoscience", and said that t ...

. The

alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

febrifugine Febrifugine is a quinazolinone alkaloid first isolated from the Chinese herb ''Dichroa febrifuga'', but also found in the garden plant ''Hydrangea''. Laboratory synthesis of febrifugine determined that the originally reported stereochemistry was i ...

and isofebrifugine are believed to be responsible for its

antimalarial Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young c ...

effects. In traditional preparations, it is used in conjunction with other plants such as ''

Glycyrrhiza glabra Liquorice (British English) or licorice (American English) ( ; also ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring can be extracted. The liqu ...

'' (licorice), ''

Ziziphus jujube Jujube (), sometimes jujuba, known by the scientific name ''Ziziphus jujuba'' and also called red date, Chinese date, and Chinese jujube, is a species in the genus ''Ziziphus'' in the buckthorn family Rhamnaceae. Description It is a small ...

'' and ''

Zingiber officinale Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. It is a herbaceous perennial which grows annual pseudostems (false stems made of the rolled bases of l ...

'' (ginger).

Potential drug against autoimmune disease

Halofuginone Halofuginone, sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb ''Dichroa febrifuga'' ...

, sold under the brand name Halocur, is a

coccidiostat A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. Examples include: * Amprolium * Arprinocid * Artemether * Clazuril * Clopidol * Decoquinate * Diclazuril * Dinitolmide * Ethopabate * Halofuginone * Lasalocid * Monens ...

used in veterinary medicine. It is a synthetic

halogen The halogens () are a group in the periodic table consisting of five or six chemically related elements: fluorine (F), chlorine (Cl), bromine (Br), iodine (I), astatine (At), and tennessine (Ts). In the modern IUPAC nomenclature, this group is ...

ated derivative of

, a natural

quinazolinone Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in med ...

alkaloid which can be found in ''dichroa febrifuga''. Halofuginone inhibits the development of

T helper 17 cell T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause Th17s to differentiate actually inhibit Treg different ...

s, immune cells that play an important role in

autoimmune disease An autoimmune disease is a condition arising from an abnormal immune response to a functioning body part. At least 80 types of autoimmune diseases have been identified, with some evidence suggesting that there may be more than 100 types. Nearly a ...

, but it does not affect other kinds of T cells which are involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders. *

References

External links

''Dichroa febrifuga'' (Google Images)Dichroa febrifuga Lour ASEAN Tropical Plant DB
Hydrangeaceae Flora of the Indian subcontinent Flora of Indo-China Medicinal plants of Asia Plants used in traditional Chinese medicine {{medicinal-plant-stub