The Developmental Studies Hybridoma Bank (DSHB) is a National Resource established by the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

(NIH) in 1986 to bank and distribute at cost hybridomas and the monoclonal antibodies (mAbs) they produce to the basic science community worldwide. It is housed in the Department of Biology at the

University of Iowa The University of Iowa (UI, U of I, UIowa, or simply Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is org ...

Mission

The mission of the DSHB is four-fold: :* Keep product prices low to facilitate research (currently 40.00 USD per ml of supernatant). :* Serve as a repository to relieve scientists of the time and expense of distributing hybridomas and the mAbs they produce. :* Assure the scientific community that mAbs with limited demand remain available. :* Maintain the highest product quality, provide prompt customer service and technical assistance.

Description

The DSHB is directed by David R. Soll at the University of Iowa. There are currently over 5000 hybridomas in the DSHB collection. The DSHB has obtained hybridomas from a variety of individuals and institutions, the latter including the

Muscular Dystrophy Association The Muscular Dystrophy Association (MDA) is an American 501(c)(3) umbrella organization that works to support people with neuromuscular diseases. Founded in 1950 by Paul Cohen, who lived with muscular dystrophy, it works to combat neuromuscular di ...

, the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

, the

NIH Common Fund The National Institutes of Health Common Fund is an initiative of the National Institutes of Health (NIH) aimed at supporting research collaboration between two or more NIH institutes and centers (ICs). The fund offers flexible support for cuttin ...

, and the

European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 and ...

(EMBL). The DSHB eagerly awaits new contributions. First time customers must agree to the DSHB terms of usage that products will be used for research purposes only, and that they cannot be commercialized or distributed to a third party. Researchers also agree to acknowledge both the DSHB and the contributing investigator and institution in publications that benefit from the use of DSHB products and provide to the DSHB citations of all publications. Individuals or institutions can deposit hybridomas for distribution at no cost. Contributing to the DSHB does not preclude the depositor from licensing cell lines for commercial purposes. The DSHB does not own any contributed intellectual property. The intellectual property remains that of the scientist and/or institution that banks the hybridomas. The DSHB covers the operating costs of maintaining, improving, producing and distributing products in the collection.

History

The DSHB was created in 1986 by the NIH to bank and distribute hybridomas and the monoclonal antibodies (mAbs) they produce to the general scientific community in order to facilitate research. The DSHB was moved from Johns Hopkins University to the University of Iowa in 1996, and placed under the directorship of David R. Soll. The DSHB has been self-funded since 1997 and relies on no outside funding.

Popular Collections

:*Cardiac Muscle :*CD Markers :*Cell Adhesion :*Cell Biomarkers :*Cytoskeleton :*Disease Biomarkers :*EMBL Protein Binders (Affinomics) :*Enzymes :*Epitope Tags :*Extracellular Matrix :*Microbes (Bacteria, Fungi, Viruses) :*Neurodevelopment :*Muscular Dystrophy Association mAbs :*NIH Common Fund Protein Capture Reagents :*NIH NCI CPTAC Cancer Targets :*Receptors :*Organelle-specific Biomarkers :*RNA/DNA Regulation :*Secreted Proteins :*Epitope Tags :*Skeletal Muscle :*Transcription Factors

Noteworthy Depositors

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

and

Alfred P. Sloan, Jr. Prize The Alfred P. Sloan Jr. Prize was a $250,000 award given by the General Motors Cancer Research Foundation for outstanding oncological research. The prize was awarded annually from 1979 to 2005. Of the winners, 15 out of 37 have gone on to win eith ...

winner

J. Michael Bishop John Michael Bishop (born February 22, 1936) is an American immunologist and microbiologist who shared the 1989 Nobel Prize in Physiology or Medicine with Harold E. Varmus and was co-winner of 1984 Alfred P. Sloan Prize. He serves as an activ ...

deposited the anti c-MYC hybridoma 9e 10

winner Sir

John Gurdon Sir John Bertrand Gurdon (born 2 October 1933) is a British developmental biologist. He is best known for his pioneering research in nuclear transplantation and cloning. He was awarded the Lasker Award in 2009. In 2012, he and Shinya Yamanaka ...

deposited MyoD clone D7F2 Nobel Prize winner

Eric F. Wieschaus Eric Francis Wieschaus (born June 8, 1947 in South Bend, Indiana) is an American evolutionary developmental biologist and 1995 Nobel Prize-winner. Early life Born in South Bend, Indiana, he attended John Carroll Catholic High School in Birming ...

deposited 7 hybridomas

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

Members who have deposited hybridomas :*Utpal Banerjee (1 hybridoma deposit)

University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...

:*Philip A. Beachy (5 hybridoma deposits)

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

:*Seymour Benzer (7 hybridoma deposits)

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

:*J. Michael Bishop (1 hybridoma deposits)

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...

:*Helen Blau (11 hybridoma deposits)

:*Kevin P. Campbell (9 hybridoma deposits)

The University of Iowa The University of Iowa (UI, U of I, UIowa, or simply Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is org ...

:*Constance L. Cepko (1 hybridoma deposit)

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

:*Max Cooper (1 hybridoma deposit)

Emory University Emory University is a private research university in Atlanta, Georgia. Founded in 1836 as "Emory College" by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory, Emory is the second-oldest private institution of ...

:*Marilyn Gist Farquhar (1 hybridoma deposit)

University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Insti ...

:*John Gurdon (1 hybridoma deposit)

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

:*Corey S. Goodman (25 hybridoma deposits)

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

:*Thomas M. Jessell (36 hybridoma deposits)

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

:*Robb Krumlauf (1 hybridoma deposit)

Stowers Institute for Medical Research The Stowers Institute for Medical Research is a biomedical research organization that conducts basic research on genes and proteins that control fundamental processes in living cells to analyze diseases and find keys to their causes, treatment, ...

:*N. M. Le Douarin (6 hybridoma deposits)

CNRS The French National Centre for Scientific Research (french: link=no, Centre national de la recherche scientifique, CNRS) is the French state research organisation and is the largest fundamental science agency in Europe. In 2016, it employed 31,637 ...

Institute of Embryology :*Gerald M. Rubin (20 hybridoma deposits) HHMI / Janelia Research Campus :*Joshua R. Sanes (11 hybridoma deposits)

:*S. J. Singer (1 hybridoma deposit)

:*Roland Nusse (2 hybridoma deposits)

:*Gertrude Schupbach (10 hybridoma deposits)

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

:*Timothy A. Springer (7 hybridoma deposits)

:*Masatoshi Takeichi (7 hybridoma deposits) RIKEN :*Stephen T. Warren (1 hybridoma deposit)

:*Zena Werb (1 hybridoma deposit)

:*Eric F. Wieschaus (7 hybridoma deposits)

References

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External links

Developmental Studies Hybridoma Bank
Developmental biology