A deoxyadenosyl radical is a
free radical
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that is structurally related to adenosine by removal of a 5′-hydroxy group from adenosine. This radical occurs in nature as a reactive intermediate. It is generated by
radical SAM
Radical SAM is a designation for a superfamily of enzymes that use a +_cluster.html" ;"title="Fe-4Ssup>+ cluster">Fe-4Ssup>+ cluster to reductively cleave ''S''-adenosyl-L-methionine (SAM) to generate a radical, usually a 5′- deoxyadenosyl rad ...
enzymes and by some varieties of
vitamin B12. The deoxyadenosyl radical abstracts hydrogen atoms from substrates, causing rearrangements and other
post transcriptional modifications required for biosynthesis.
[{{cite journal, authors=Broderick, J. B.; Duffus, B. R.; Duschene, K. S.; Shepard, E. M. , title=Radical ''S''-Adenosylmethionine Enzymes, journal=Chemical Reviews, year=2014, volume=114, issue=8, pages=4229–4317, doi= 10.1021/cr4004709, pmid=24476342, pmc=4002137]
References
Enzymes
Free radicals