Delta-3-THC
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Delta-3-Tetrahydrocannabinol (Delta-3-THC, Δ3-THC, Δ6a(10a)-THC, EA-1477) is a synthetic isomer of
tetrahydrocannabinol Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC'' ...
, developed during the original research in the 1940s to develop synthetic routes to the
natural product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical syn ...
s Δ8-THC and Δ9-THC found in the
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: ''Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternatively ...
plant. While the normal ''trans'' configuration of THC is in this case flattened by the double bond, it still has two enantiomers as the 9-methyl group can exist in an (R) or (S) conformation. The (S) enantiomer has similar effects to Δ9-THC though with several times lower potency, while the (R) enantiomer is many times less active or inactive, depending on the assay used.


See also

* 7,8-Dihydrocannabinol * Cannabitriol * Delta-4-Tetrahydrocannabinol *
Delta-7-Tetrahydrocannabinol Delta-7-Tetrahydrocannabinol (alternatively numbered as Delta-5-Tetrahydrocannabinol, Δ5-THC, Δ7-THC) is a synthetic isomer of tetrahydrocannabinol. The (6aR,9S,10aR)-Δ7-THC epimer is only slightly less potent than Δ9-THC itself, while the (9 ...
* Delta-10-Tetrahydrocannabinol *
Hexahydrocannabinol Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol. It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in ''Cannabis sativa'', but can also be produced synthetically by hy ...
*
JWH-138 JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesised by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor. Isomers The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less ...
* Parahexyl


References

Benzochromenes Cannabinoids Heterocyclic compounds with 3 rings {{pharm-stub