De Wet is the name of:
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Jacob Willemszoon de Wet (c. 1610 – between 1675 and 1691), Dutch painter
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Christiaan de Wet (1854–1922), Boer general, rebel leader and politician
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De Wet Decoration, South African military medal named after the above
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Nicolaas Jacobus de Wet (1873–1960), Chief Justice of South Africa and acting Governor-General
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Quartus de Wet (1899–1980), son of the above, South African judge and judge-president of the Transvaal, and presiding judge of the 1963 Rivonia Trial, where he sentenced Nelson Mandela and other anti-apartheid activists to life imprisonment.
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Johannes Christiaan de Wet (1912–1990), South African jurist
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De Wet Barry (born 1978), South African rugby union footballer
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Friedel de Wet (born 1980), South African cricketer
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Jane de Wet (born 1996), South African actress
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Dutch-language surnames
Afrikaans-language surnames