The C
4-dicarboxylate uptake C family or DcuC family
TC# 2.A.61 is a
family
Family (from la, familia) is a Social group, group of people related either by consanguinity (by recognized birth) or Affinity (law), affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its ...
of transmembrane
ion transporter
In biology, a transporter is a transmembrane protein that moves ions (or other small molecules) across a biological membrane to accomplish many different biological functions including, cellular communication, maintaining homeostasis, energy produc ...
s found in bacteria. A representative list of proteins belonging to the DcuC family can be found in the
Transporter Classification Database.
An anaerobic C
4-dicarboxylate transporter (DcuC) of ''E. coli''
TC# 2.A.61.1.1 has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by
glucose
Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using ...
. DcuC may therefore function as a
succinate
Succinic acid () is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2. The name derives from Latin ''succinum'', meaning amber. In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological ro ...
efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in
catalysing fumarate-succinate exchange and fumarate uptake.
DcuC shows the same
transport
Transport (in British English), or transportation (in American English), is the intentional movement of humans, animals, and goods from one location to another. Modes of transport include air, land (rail and road), water, cable, pipeline, an ...
modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).
The reactions probably catalyzed by the ''E. coli'' DcuC protein are:
# C
4-dicarboxylate (out) + nH+ (out) → C
4-dicarboxylate (in) + nH+ (in)
# C
4-dicarboxylate
1 (out) + C
4-dicarboxylate
2 (in) ⇌ C
4-dicarboxylate
1 (in) + C
4-dicarboxylate
2 (out).
See also
*
Dicarboxylate
In organic chemistry, a carboxylate is the conjugate base of a carboxylic acid, (or ). It is an ion with negative charge.
Carboxylate salts are salts that have the general formula , where M is a metal and ''n'' is 1, 2,...; ''carboxylat ...
*
Dcu family
References
Protein families
Transmembrane transporters
{{membrane-protein-stub