David Lawrence Rimoin (November 9, 1936 – May 27, 2012) was a

Canadian American Canadian Americans is a term that can be applied to Citizenship of the United States, American citizens whose ancestry is wholly or partly Canadians, Canadian, or citizens of either country that hold dual citizenship. The term ''Canadian'' can ...

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processe ...

. He was especially noted for his research into the

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...

skeletal dysplasia Osteochondrodysplasia is a general term for a disorder of the development (dysplasia) of bone ("osteo") and cartilage ("chondro"). Osteochondrodysplasias are rare diseases. About 1 in 5,000 babies are born with some type of skeletal dysplasia. Non ...

(

dwarfism Dwarfism is a condition wherein an organism is exceptionally small, and mostly occurs in the animal kingdom. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dw ...

), inheritable diseases such as

Tay–Sachs disease Tay–Sachs disease is a genetic disorder that results in the destruction of nerve cells in the brain and spinal cord. The most common form is infantile Tay–Sachs disease, which becomes apparent around three to six months of age, with the baby ...

, and

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

.Thomas H. Maugh, II
"Dr. David L. Rimoin dies at 75; Cedars-Sinai geneticist"
''

Los Angeles Times The ''Los Angeles Times'' (abbreviated as ''LA Times'') is a daily newspaper that started publishing in Los Angeles in 1881. Based in the LA-adjacent suburb of El Segundo since 2018, it is the sixth-largest newspaper by circulation in the Un ...

'', May 30, 2012."Dr. David Rimoin, pioneering geneticist, dies at 75"
''

The Jewish Journal of Greater Los Angeles ''The Jewish Journal of Greater Los Angeles'', known simply as the ''Jewish Journal'', is an independent, nonprofit community weekly newspaper serving the Jewish community of greater Los Angeles, published by TRIBE Media Corp. ''The Journal'' wa ...

'', May 29, 2012.

Biography

Rimoin was born in

Montreal Montreal ( ; officially Montréal, ) is the List of the largest municipalities in Canada by population, second-most populous city in Canada and List of towns in Quebec, most populous city in the Provinces and territories of Canada, Canadian ...

, the son of Fay (Lecker) and Michael Rimoin. Rimoin attended college and medical school at

McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...

, where he received his

bachelor's degree A bachelor's degree (from Middle Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate academic degree awarded by colleges and universities upon completion of a course of study lasting three to six ...

in 1957, followed by a

medical degree A medical degree is a professional degree admitted to those who have passed coursework in the fields of medicine and/or surgery from an accredited medical school. Obtaining a degree in medicine allows for the recipient to continue on into special ...

and a

Master of Science A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast to ...

in genetics in 1961. He followed with internships and residencies at Royal Victoria Hospital in Montreal and at

Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 mo ...

Baltimore Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...

, where he studied under genetics pioneer

Victor A. McKusick Victor Almon McKusick (October 21, 1921 – July 22, 2008) was an American internist and medical geneticist, and Professor of Medicine at the Johns Hopkins Hospital, Baltimore. He was a proponent of the mapping of the human genome due to its ...

Betty M. Adelson, ''Dwarfism: Medical And Psychosocial Aspects Of Profound Short Stature'' (

JHU Press The Johns Hopkins University Press (also referred to as JHU Press or JHUP) is the publishing division of Johns Hopkins University. It was founded in 1878 and is the oldest continuously running university press in the United States. The press publi ...

, 2005), , pp. 51-52
Excerpts available
at

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. and received a

Ph.D A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields ...

medical genetics Medical genetics is the branch tics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the caus ...

. He spent three years at the

Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or ...

St. Louis, Missouri St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi River, Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the Greater St. Louis, ...

where his first daughter Anne Walsh Rimoin was born. His 1970 study of

diabetes mellitus Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

challenged the then-prevailing consensus that diabetes was a single disorder, and showed instead that it could have multiple genetic causes. In 1970 Rimoin moved to Harbor-UCLA Medical Center in

Los Angeles Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the largest city in the state of California and the second most populous city in the United States after New York City, as well as one of the world' ...

, where he became chief of the division of medical genetics. He moved to

Cedars-Sinai Medical Center Cedars-Sinai Medical Center is a nonprofit, tertiary, 886-bed teaching hospital and multi-specialty academic health science center located in Los Angeles, California. Part of the Cedars-Sinai Health System, the hospital employs a staff of over 2 ...

in 1986. He founded the International Skeletal Dysplasia Registry. Together with

Michael Kaback Michael M. Kaback, M.D. is a geneticist, physician, and Professor of Pediatrics and Reproductive Medicine, and chief of the Division of Medical Genetics, at the University of California–San Diego. He is best known for his role in the discove ...

, he organized a California Tay-Sachs screening program that became a national model. Rimoin and English geneticist Alan E. H. Emery co-edited ''Principles and Practice of Medical Genetics'', first published in 1983 and now considered an essential textbook on the subject. At Cedars-Sinai he was chair of the

pediatrics Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until th ...

practice, established an adult genetics program, and began a screening program focused on genetic diseases within Los Angeles' large population of

Persian Jews Persian Jews or Iranian Jews ( fa, یهودیان ایرانی, ''yahudiān-e-Irāni''; he, יהודים פרסים ''Yəhūdīm Parsīm'') are the descendants of Jews who were historically associated with the Persian Empire, whose successor ...

. Dr. David Rimoin was mentioned in Frederick Drimmer's book "Very Special People". It stated that he had found that growth hormone could help pituitary dwarfs achieve close to normal height. Obtained from the pituitaries of human cadavers, it had not been available in sufficient supply. In 1997–98, Rimoin was the first president of the

American College of Medical Genetics and Genomics The American College of Medical Genetics and Genomics (ACMG) is an organization composed of biochemical, clinical, cytogenetic, medical and molecular geneticists, genetic counselors and other health care professionals committed to the practice of ...

After his death, the ACMG established two awards in his honor, the David L. Rimoin Lifetime Achievement Award in Medical Genetics and the David L. Rimoin Inspiring Excellence Award."Marcus Miller, Ph.D., Receives ACMG Foundation/David L. Rimoin Inspiring Excellence Award"
'' News Rx Health and Science'', April 19, 2015 . Rimoin died in Los Angeles on May 27, 2012, days after having been diagnosed with

pancreatic cancer Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of t ...

. He is survived by his second wife, Ann Garber Rimoin, his two daughters Anne Rimoin and Lauren Rimoin and his son Michael Rimoin.

References

External links

Interview with David L. Rimoin

UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...

Oral History of Human Genetics Project (accessed 2012-06-01). {{DEFAULTSORT:Rimoin, David 1936 births 2012 deaths American geneticists Canadian geneticists Medical geneticists Physicians from Montreal McGill University Faculty of Medicine alumni Johns Hopkins School of Medicine alumni Deaths from cancer in California Deaths from pancreatic cancer Physicians of the Cedars-Sinai Medical Center 20th-century Canadian biologists 20th-century American biologists 20th-century Canadian physicians 20th-century American physicians Canadian emigrants to the United States Members of the National Academy of Medicine