David Jay Julius (born November 4, 1955) is an American

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...

and

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

laureate known for his work on molecular mechanisms of

pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ...

sensation and heat, including the characterization of the

TRPV1 The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the ''TRPV1'' gene. It was the first isolated member of th ...

and

TRPM8 Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular t ...

receptors that detect

capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burning ...

menthol Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and ...

, and temperature. He is a professor at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...

. Julius won the 2010

Shaw Prize The Shaw Prize is an annual award presented by the Shaw Prize Foundation. Established in 2002 in Hong Kong, it honours "individuals who are currently active in their respective fields and who have recently achieved distinguished and signifi ...

Life Science Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energy t ...

and

Medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

and the 2020

Breakthrough Prize in Life Sciences The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of the ...

. He was awarded the

2021 Nobel Prize in Physiology or Medicine The 2021 Nobel Prize in Physiology or Medicine was jointly awarded to the American physiologist David Julius (b. 1955) and Armenian-American neuroscientist Ardem Patapoutian (b. 1967) "for the discovery of receptors for temperature and touch." Dur ...

jointly with

Ardem Patapoutian Ardem Patapoutian (born 1967) is an Armenian-American molecular biologist, neuroscientist, and Nobel Prize laureate. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperatur ...

Early life and education

Julius was born to an

Ashkenazi Jewish Ashkenazi Jews ( ; he, יְהוּדֵי אַשְׁכְּנַז, translit=Yehudei Ashkenaz, ; yi, אַשכּנזישע ייִדן, Ashkenazishe Yidn), also known as Ashkenazic Jews or ''Ashkenazim'',, Ashkenazi Hebrew pronunciation: , singu ...

family (from Russia) in

Brighton Beach Brighton Beach is a List of Brooklyn neighborhoods, neighborhood in the southern portion of the New York City Borough (New York City), borough of Brooklyn, within the greater Coney Island area along the Atlantic Ocean coastline. Brighton Beach i ...

Brooklyn Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York. Kings County is the most populous county in the State of New York, and the second-most densely populated county in the United States, be ...

, New York City, where he attended Abraham Lincoln High School. He earned his undergraduate degree from

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

in 1977. He attained his doctorate from

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

in 1984, under joint supervision of Jeremy Thorner and

Randy Schekman Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley, former editor-in-chief of ''Proceedings of the National Academy of Sciences'' and former editor of ''Annual Review of Cell and ...

, where he identified Kex2 as the founding member of

furin Furin is a protease, a proteolytic enzyme that in humans and other animals is encoded by the ''FURIN'' gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these s ...

-like proprotein convertases. In 1989, he completed his

post-doctoral training A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a Doctor of Philosophy, PhD). The ultimate goal of a postdoctoral rese ...

with

Richard Axel Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won hi ...

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

where he cloned and characterized the serotonin 1c receptor. While at Berkeley and Columbia, Julius became interested in how

psilocybin mushroom Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of mushroom, fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocyb ...

s and

lysergic acid diethylamide Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...

work, which led him to look more broadly into how things from nature interact with human receptors.

Research career

22 Hegasy EN Nobel Prize 2021 TRPV1 Piezo2

He started his career as faculty at the

in 1989. In 1997, Julius's lab cloned and characterized

which is the receptor that detects

, the chemical in

chili pepper Chili peppers (also chile, chile pepper, chilli pepper, or chilli), from Nahuatl '' chīlli'' (), are varieties of the berry-fruit of plants from the genus ''Capsicum'', which are members of the nightshade family Solanaceae, cultivated for ...

s that makes them "hot". They found that

also detects noxious heat (

thermoception Thermoception or thermoreception is the sensation and perception of temperature, or more accurately, temperature differences inferred from heat flux. It deals with a series of events and processes required for an organism to receive a temperature s ...

). TRPV1 is part of a large family of structurally related TRP (transient receptor potential) cation channels. Animals that lack TRPV1 (using genetic knockouts of the protein) lose sensitivity to noxious heat and capsaicin. Julius's lab has also cloned and characterized

(CMR1) and

TRPA1 Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the ''TRPA1'' (and in mice and rats by the ''Trpa1' ...

, both members of the TRP superfamily. They demonstrated that TRPM8 detects

and cooler temperatures and

detects

mustard oil Mustard oil can mean either the pressed oil used for cooking, or a pungent essential oil also known as volatile oil of mustard. The essential oil results from grinding mustard seed, mixing the grounds with water, and extracting the resulting vol ...

(allyl isothiocyanate). These observations suggested that TRP channels detect a range of temperatures and chemicals. David Julius's lab has also made contributions to the study of

nociception Nociception (also nocioception, from Latin ''nocere'' 'to harm or hurt') is the sensory nervous system's process of encoding noxious stimuli. It deals with a series of events and processes required for an organism to receive a painful stimulus, co ...

by discovering toxins that modulate these channels, describing unique adaptations of the channels in diverse species and solving the

cryo-EM Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample sol ...

structures of numerous channels. From 2007–2020 Julius served as the editor of the peer-reviewed journal the ''

Annual Review of Physiology The ''Annual Review of Physiology'' is a peer-reviewed academic journal that publishes review articles about physiology. First published in 1939 through a collaboration between the American Physiological Society and Annual Reviews, it was publish ...

''.

Awards

In 2000, Julius was awarded the inaugural Perl-UNC Neuroscience Prize for his work on cloning the capsaicin receptor. In 2010, he won the

for his work identifying the

ion channel Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...

s involved in various aspects of

. In 2014, he was honored by

Johnson & Johnson Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Its common stock is a component of the Dow Jones Industrial Average and the company i ...

with the Dr. Paul Janssen Award for Biomedical Research for discovering the molecular basis for pain and thermosensation. In 2017, he won the

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

and the HFSP Nakasone Award. He has also been awarded the 2010

Prince of Asturias Prize The Princess of Asturias Awards ( es, Premios Princesa de Asturias, links=no, ast, Premios Princesa d'Asturies, links=no), formerly the Prince of Asturias Awards from 1981 to 2014 ( es, Premios Príncipe de Asturias, links=no), are a series of a ...

for Technical and Scientific Research, the 2020

, and the 2020

Kavli Prize The Kavli Prize was established in 2005 as a joint venture of the Norwegian Academy of Science and Letters, the Norwegian Ministry of Education and Research, and the Kavli Foundation. It honors, supports, and recognizes scientists for outstand ...

in Neuroscience (together with

) and the 2020

BBVA Foundation Frontiers of Knowledge Award The BBVA Foundation Frontiers of Knowledge Awards () are an international award programme recognizing significant contributions in the areas of scientific research and cultural creation. The categories that make up the Frontiers of Knowledge Awards ...

. In 2021, he was awarded the

in Physiology or Medicine jointly with

for their discoveries of receptors for temperature and touch.

References

External links

Website at UCSFUCSF Profiles - David Julius
{{DEFAULTSORT:Julius, David 1955 births Abraham Lincoln High School (Brooklyn) alumni American people of Russian-Jewish descent American physiologists Annual Reviews (publisher) editors Jewish American scientists Kavli Prize laureates in Neuroscience Living people Massachusetts Institute of Technology alumni Members of the United States National Academy of Sciences Nobel laureates in Physiology or Medicine Scientists from New York City University of California, Berkeley alumni Columbia University staff University of California, San Francisco faculty