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David Julius
David Jay Julius (born November 4, 1955) is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California, San Francisco. Julius won the 2010 Shaw Prize in Life Science and Medicine and the 2020 Breakthrough Prize in Life Sciences. In 2020 he was awarded The Kavli Prize, and in 2021 the Nobel Prize in Physiology or Medicine jointly with Ardem Patapoutian. Early life and education Julius was born to an Ashkenazi Jewish family (from Russia) in Brighton Beach, Brooklyn, New York City, where he attended Abraham Lincoln High School. He earned his undergraduate degree from Massachusetts Institute of Technology in 1977. He attained his doctorate from University of California, Berkeley in 1984, under joint supervision of Jeremy Thorner and Randy Schekman, wher ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and science. In response to the increasing Technological and industrial history of the United States, industrialization of the United States, William Barton Rogers organized a school in Boston to create "useful knowledge." Initially funded by a land-grant universities, federal land grant, the institute adopted a Polytechnic, polytechnic model that stressed laboratory instruction in applied science and engineering. MIT moved from Boston to Cambridge in 1916 and grew rapidly through collaboration with private industry, military branches, and new federal basic research agencies, the formation of which was influenced by MIT faculty like Vannevar Bush. In the late twentieth century, MIT became a leading center for research in compu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize
The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred Nobel, Alfred Nobel's death. The original Nobel Prizes covered five fields: Nobel Prize in Physics, physics, Nobel Prize in Chemistry, chemistry, Nobel Prize in Physiology or Medicine, physiology or medicine, Nobel Prize in Literature, literature, and Nobel Peace Prize, peace, specified in Nobel's will. A sixth prize, the Nobel Memorial Prize in Economic Sciences, Prize in Economic Sciences, was established in 1968 by Sveriges Riksbank (Sweden's central bank) in memory of Alfred Nobel. The Nobel Prizes are widely regarded as the most prestigious awards available in their respective fields.Nobel Prize#Shalev69, Shalev, p. 8. Except in extraordinary circumstances, such as war, all six prizes are given annually. Each recipient, known as a laur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashkenazi Jewish
Ashkenazi Jews ( ; also known as Ashkenazic Jews or Ashkenazim) form a distinct subgroup of the Jewish diaspora, that Ethnogenesis, emerged in the Holy Roman Empire around the end of the first millennium Common era, CE. They traditionally speak Yiddish, a language that originated in the 9th century, and largely migrated towards Northern Europe#UN geoscheme classification, northern and eastern Europe during the late Middle Ages due to Antisemitism in Europe, persecution. Hebrew was primarily used as a Literary language, literary and sacred language until its 20th-century Revival of the Hebrew language, revival as a common language in Israel. Ashkenazim adapted their traditions to Europe and underwent a transformation in their interpretation of Judaism. In the late 18th and 19th centuries, Jews who remained in or returned to historical German lands experienced a cultural reorientation. Under the influence of the Haskalah and the struggle for emancipation, as well as the intellec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ardem Patapoutian
Ardem Patapoutian (born 1 October 1967) is a Lebanese-American molecular biologist, neuroscientist, and Nobel Prize laureate of Armenian descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research in La Jolla, California. In 2021, he won the Nobel Prize in Physiology or Medicine jointly with David Julius. Early life Ardem Patapoutian () was born to a Lebanese Armenian family in Beirut, Lebanon. His father, Sarkis Patapoutian (better known by the pen name ), is a poet and an accountant, while his mother, Haiguhi Adjemian, was the principal of an Armenian school in Beirut. He has a brother, Ara, and a sister, Houry. His grandparents settled in Lebanon from Hadjin after surviving the Armenian Genocide. He is childhood friends with journalist and author Vicken Cheterian. He attended the Demirdji ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2021 Nobel Prize In Physiology Or Medicine
The 2021 Nobel Prize in Physiology or Medicine was jointly awarded to the American physiologist David Julius (b. 1955) and Armenian-American neuroscientist Ardem Patapoutian (b. 1967) "for the discovery of receptors for temperature and touch." During the award ceremony on December 10, 2021, Nobel Assembly at Karolinska Institutet member Patrik Ernfors expressed: Laureates David Julius David Julius was born in 1955 in New York, United States. He received a Ph.D. in 1984 from University of California, Berkeley and was a postdoctoral fellow at Columbia University in New York. In 1989, David Julius was recruited as professor to the University of California, San Francisco. He was the recipient of numerous prestigious awards such as the 2010 Shaw Prize in Life Sciences and Medicine, the 2010 Prince of Asturias Prize for Technical and Scientific Research, the 2020 Breakthrough Prize in Life Sciences, and the 2020 Kavli Prize in Neuroscience (together with Patapoutian) and the 2020 BB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kavli Prize
The Kavli Prize was established in 2005 as a joint venture of the Norwegian Academy of Science and Letters, the Norwegian Ministry of Education and Research, and the Kavli Foundation (United States), Kavli Foundation. It honors, supports, and recognizes scientists for outstanding work in the fields of astrophysics, nanoscience and neuroscience. Three prizes are awarded every second year. Each of the three Kavli Prizes consists of a gold medal, a scroll, and a cash award of US$1,000,000. The medal has a diameter of , a thickness of , and weighs . The first Kavli Prizes were awarded on 9 September 2008 in Oslo, presented by Haakon, Crown Prince of Norway. Selection committees The Norwegian Academy of Science and Letters appoints three prize committees consisting of leading international scientists after receiving recommendations made from the following organisations: *Chinese Academy of Sciences *French Academy of Sciences *Max Planck Society *United States National Academy o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicine
Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, and Health promotion, promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention (medical), prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, medical genetics, genetics, and medical technology to diagnosis (medical), diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, splint (medicine), external splints and traction, medical devices, biologic medical product, biologics, and Radiation (medicine), ionizing radiation, amongst others. Medicine has been practiced since Prehistoric medicine, prehistoric times, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Science
Life, also known as biota, refers to matter that has biological processes, such as signaling and self-sustaining processes. It is defined descriptively by the capacity for homeostasis, organisation, metabolism, growth, adaptation, response to stimuli, and reproduction. All life over time eventually reaches a state of death, and none is immortal. Many philosophical definitions of living systems have been proposed, such as self-organizing systems. Viruses in particular make definition difficult as they replicate only in host cells. Life exists all over the Earth in air, water, and soil, with many ecosystems forming the biosphere. Some of these are harsh environments occupied only by extremophiles. Life has been studied since ancient times, with theories such as Empedocles's materialism asserting that it was composed of four eternal elements, and Aristotle's hylomorphism asserting that living things have souls and embody both form and matter. Life originated at least ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shaw Prize
The Shaw Prize is a set of three annual awards presented by the Shaw Prize Foundation in the fields of astronomy, medicine and life sciences, and mathematical sciences. Established in 2002 in Hong Kong, by Hong Kong entertainment mogul and philanthropist Run Run Shaw (邵逸夫), the awards honour "individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence." The prize has been described as the "Nobel of the East". Award The prize consists of three awards in the fields of astronomy, life science and medicine, and mathematical sciences; it is not awarded posthumously. Nominations are submitted by invited individuals beginning each year in September. Winners are announced in the summer and receive the award at a ceremony in early autumn. Each award consists of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Menthol
Menthol is an organic compound, specifically a Monoterpene, monoterpenoid, that occurs naturally in the oils of several plants in the Mentha, mint family, such as Mentha arvensis, corn mint and peppermint. It is a white or clear waxy crystalline substance that is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1''R'',2''S'',5''R'') Cahn–Ingold–Prelog priority rules, configuration. For many people, menthol produces a cooling sensation when inhaled, eaten, or applied to the skin, and mint plants have been used for centuries for topical pain relief and as a food flavoring. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol has been demonstrated to cause a subjective nasal decongestant effect without any objective decongestant action, and administration of menthol via a nasal inhaler in humans has also been shown t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Capsaicin
Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) (, rarely ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a potent Irritation, irritant for Mammal, mammals, including humans, and produces a sensation of burning in any Tissue (biology), tissue with which it comes into contact. Capsaicin and several related amides (capsaicinoids) are produced as secondary metabolites by chili peppers, likely as deterrents against certain mammals and fungi. Pure capsaicin is a hydrophobic, colorless, highly pungent (i.e., spicy) crystalline solid. Natural function Capsaicin is present in large quantities in the Placentation#In plants, placental tissue (which holds the seeds), the internal membranes and, to a lesser extent, the other fleshy parts of the fruits of plants in the genus ''Capsicum''. The seeds themselves do not produce any capsaicin, although the highest concentration of capsaicin can be found in the white Fruit anatomy#Mesocar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRPM8
Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor). Structure The TRPM8 channel is a homotetramer, composed of four identical subunits with a transmembrane domain with six helices (S1–6). The first four, S1–4, act as the voltage sensor and allow binding of menthol, icilin and similar channel agonists. S5 and S6 and a connecting loop, also part of the structure, make up the pore, a non-selective cation channel which consists of a highly conserved hydrophobic region. A range of diverse components are required for the high level of specificity in response to cold and menthol stimuli which eventually lead to ion flow through ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
