DPA-713 or ''N'',''N''-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolo
,5-''a''yrimidine-3-acetamide is a selective ligand for the
translocator protein (TSPO).
The
binding affinity of DPA-713 for TSPO is reported as ''K''
i = 4.7 ± 0.2 nM.
DPA-713 has been radiolabelled with
carbon-11 as a potential
radiotracer for imaging the TSPO using
positron emission tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in Metabolism, metabolic processes, and in other physiological activities including bl ...
(PET).
Radiation dosimetry and biodistribution of
sup>11CPA-713 have been assessed in healthy volunteers, indicating that
sup>11CPA-713 is a suitable
radiotracer for imaging the TSPO in humans.
See also
*
DPA-714
DPA-714 or ''N'',''N''-diethyl-2- -(2-fluoroethoxy)phenyl5,7-dimethylpyrazolo ,5-''a''yrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications. For this rea ...
References
{{Translocator protein modulators
Pyrazolopyrimidines
TSPO ligands