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{{Refimprove, date=April 2008 DIALIGN-TX is a
multiple sequence alignment Multiple sequence alignment (MSA) may refer to the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutio ...
program written by Amarendran R. Subramanian and is substantial improvement of DIALIGN-T by combining greedy and progressive alignment strategies in a new algorithm. The original
DIALIGN-T {{Refimprove, date=April 2008 DIALIGN-TX is a multiple sequence alignment program written by Amarendran R. Subramanian and is substantial improvement of DIALIGN-T by combining greedy and progressive alignment strategies in a new algorithm. The ori ...
is a reimplementation of the multiple-alignment program DIALIGN. Due to several algorithmic improvements, it produces significantly better alignments on locally and globally related sequence sets than previous versions of DIALIGN. However, like the original implementation of the program, DIALIGN-T uses a straightforward greedy approach to assemble multiple alignments from local pairwise sequence similarities. Such greedy approaches may be vulnerable to spurious random similarities and can therefore lead to suboptimal results. DIALIGN-TX is a substantial improvement of DIALIGN-T that combines the previous greedy algorithm with a progressive alignment approach.


See also

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DIALIGN-T {{Refimprove, date=April 2008 DIALIGN-TX is a multiple sequence alignment program written by Amarendran R. Subramanian and is substantial improvement of DIALIGN-T by combining greedy and progressive alignment strategies in a new algorithm. The ori ...
*
Sequence alignment software This list of sequence alignment software is a compilation of software tools and web portals used in pairwise sequence alignment and multiple sequence alignment. See structural alignment software for structural alignment of proteins. Database sear ...
*
Clustal Clustal is a series of widely used computer programs used in bioinformatics for multiple sequence alignment. There have been many versions of Clustal over the development of the algorithm that are listed below. The analysis of each tool and its a ...


References

* Subramanian AR, Kaufmann M, Morgenstern B. DIALIGN-TX: Greedy and progressive approaches for segment-based multiple sequence alignment. ''Algorithms for Molecular Biology'' 2008, 3:6 * Subramanian AR, Weyer-Menkhoff J, Kaufmann M, Morgenstern B. DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment. ''BMC Bioinformatics'' 2005, 6:66


External links


Official website
Phylogenetics software