D-threose
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Threose is a four-carbon
monosaccharide Monosaccharides (from Greek ''monos'': single, '' sacchar'': sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. They are usually colorless, water-solub ...
with
molecular formula In chemistry, a chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, ...
C4H8O4. It has a terminal
aldehyde In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl grou ...
group rather than a
ketone In organic chemistry, a ketone is a functional group with the structure R–C(=O)–R', where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group –C(=O)– (which contains a carbon-oxygen double bo ...
in its linear chain, and so is considered part of the
aldose An aldose is a monosaccharide (a simple sugar) with a carbon backbone chain with a carbonyl group on the endmost carbon atom, making it an aldehyde, and hydroxyl groups connected to all the other carbon atoms. Aldoses can be distinguished from keto ...
family of
monosaccharide Monosaccharides (from Greek ''monos'': single, '' sacchar'': sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. They are usually colorless, water-solub ...
s. The threose name can be used to refer to both the D- and L-
stereoisomer In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in ...
s, and more generally to the racemic mixture (D/L-, equal parts D- and L-) as well as to the more generic threose structure (absolute stereochemistry unspecified). The prefix "threo" which derives from threose (and "erythro" from a corresponding
diastereomer In stereochemistry, diastereomers (sometimes called diastereoisomers) are a type of stereoisomer. Diastereomers are defined as non-mirror image, non-identical stereoisomers. Hence, they occur when two or more stereoisomers of a compound have dif ...
erythrose Erythrose is a tetrose saccharide with the chemical formula C4H8O4. It has one aldehyde group, and is thus part of the aldose family. The natural isomer is D-erythrose; it is a diastereomer of D -threose. Erythrose was first isolated in 1849 ...
) offer a useful way to describe general organic structures with adjacent chiral centers, where "the prefixes... designate the relative configuration of the centers".Formulas Using Other Configurational Notations
W. Rausch, accessed 1 March 2011
As is depicted in a
Fischer projection In chemistry, the Fischer projection, devised by Emil Fischer in 1891, is a two-dimensional representation of a three-dimensional organic molecule by projection. Fischer projections were originally proposed for the depiction of carbohydrates an ...
of D-threose, the adjacent substituents will have a syn orientation in the isomer referred to as "threo", and are
anti Anti may refer to: *Anti-, a prefix meaning "against" *Änti, or Antaeus, a half-giant in Greek and Berber mythology *A false reading of ''Nemty'', the name of the ferryman who carried Isis to Set's island in Egyptian mythology * Áńt’į, or ...
in the isomer referred to as "erythro".Prof. Rausch helpfully notes that the prefixes "may be applied to racemic compounds, as well as pure enantiomers and meso compounds", and that when depicted in the common "zig-zag" representation, adjacent "substituents may lie on the same side of the carbon chain... ynor on opposite sides...
nti Nti is a surname. Notable people with the surname include: * Collins Agyarko Nti (born 1958), Ghanaian politician * Opoku Nti (born 1961), Ghanaian footballer * Theophidack Nti (born 1977), Ghanaian footballer {{Surname Surnames of African ori ...
, which is opposite of their depiction in a
Fischer projection In chemistry, the Fischer projection, devised by Emil Fischer in 1891, is a two-dimensional representation of a three-dimensional organic molecule by projection. Fischer projections were originally proposed for the depiction of carbohydrates an ...
.


See also

*
Threitol Threitol is a four-carbon sugar alcohol with the molecular formula C4H10O4. It is primarily used as an intermediate in the chemical synthesis of other compounds. It is the diastereomer of erythritol, which is used as a sugar substitute. In livin ...
*
Threonic acid Threonic acid is a sugar acid derived from threose. The -isomer is a metabolite of ascorbic acid (vitamin C). One study suggested that because -threonate inhibits DKK1 expression ''in vitro'', it may have potential in treatment of androgenic alope ...
*
Threose nucleic acid Threose nucleic acid (TNA) is an artificial genetic polymer in which the natural five-carbon ribose sugar found in RNA has been replaced by an unnatural four-carbon threose sugar.Schöning, K. U. ''et al.'' Chemical etiology of nucleic acid structur ...


References

{{Carbohydrates Aldotetroses