Cucurmosin is a type I

ribosome inactivating protein A ribosome-inactivating protein (RIP) is a protein synthesis inhibitor that acts at the eukaryotic ribosome. This protein family describes a large family of such proteins that work by acting as rRNA N-glycosylase (EC 3.2.2.22). They inactivate 6 ...

(RIP) found in the sarcocarp (flesh) and seed of ''

Cucurbita ''Cucurbita'' (Latin for gourd) is a genus of herbaceous fruits in the gourd family, Cucurbitaceae (also known as ''cucurbits'' or ''cucurbi''), native to the Andes and Mesoamerica. Five edible species are grown and consumed for their flesh and ...

'' — notably ''

Cucurbita moschata ''Cucurbita moschata'' is a species originating in either Central America or northern South America. It includes cultivars known as squash or pumpkin. ''C. moschata'' cultivars are generally more tolerant of hot, humid weather than cultivars of ' ...

'', that is toxic to cancer cells, if the dosage is high enough, by stopping their

ribosome Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to ...

s. Cucurmosin is what ''Cucurbita'' use to defend against viral, fungal, and bacterial agents. It takes a lower dose of cucurmosin to kill cancer cells than healthy cells. It has been shown to induce

apoptosis Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...

in pancreatic cancer and

myeloid Myeloid tissue, in the bone marrow sense of the word '' myeloid'' ('' myelo-'' + ''-oid''), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (''myelo-'' + '' -genous'') is any tissue of, ...

leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...

cells.

References

{{Reflist Protein biosynthesis Plant toxins Ribosome-inactivating proteins