Clotizolam (Ro11-1465) is a
thienotriazolodiazepine
A thienotriazolodiazepine is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:
* Brotizolam
* Ciclotizolam
* De ...
derivative first invented in the 1970s, which in more recent years has been sold as a
designer drug. As with other related thienotriazolodiazepines, it produces
sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but t ...
,
anxiolytic,
anticonvulsant
Anticonvulsants (also known as antiepileptic drugs or recently as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of b ...
and
muscle relaxant effects,
and also acts as an inhibitor of
platelet-activating factor (PAF).
See also
*
Brotizolam
Brotizolam (marketed under brand name Lendormin) is a sedative-hypnotic thienotriazolodiazepine drug which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is con ...
*
Etizolam
Etizolam (marketed under many brand names) is a thienodiazepine derivative which is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring ha ...
*
Flubrotizolam
Flubrotizolam (2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno,2-f1,2,4]triazolo ,3-a1,4]diazepine) is a thienotriazolodiazepine derivative with potent sedative and anxiolytic effects, which has been sold as a designer drug.
See also
* Brotizola ...
*
Fluclotizolam
Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.
See also
* Brotizolam
* Clotizola ...
*
Deschloroclotizolam
Deschloroclotizolam is a thienotriazolodiazepine derivative which has been sold as a designer drug, first being identified in Sweden in 2021.
See also
* Alprazolam
* Clotizolam
* Fluclotizolam
* Deschloroetizolam
Deschloroetizolam (also kno ...
*
Ro09-9212
Ro09-9212 is a thienodiazepine derivative with sedative and anxiolytic effects, which has been sold as a designer drug.
See also
* Clotiazepam
* Clotizolam
* Diclazepam
* Etizolam
* Flubrotizolam
* Fluclotizolam
Fluclotizolam is a thieno ...
*
Triazolam
References
Designer drugs
GABAA receptor positive allosteric modulators
Thienotriazolodiazepines
Chloroarenes
Phenyl compounds
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