In
histology
Histology,
also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vi ...
, a clear cell is a cell that shows a clear
cytoplasm
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. ...
when stained with
hematoxylin and eosin (H&E).
Normal histology
In the skin, some
secretory cell 440px
Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classica ...
s in the
epithelium appear as clear cells, and are one of the components of
eccrine sweat glands. A clear cell's
plasma membrane is highly folded, more so on the apical and lateral surfaces. The cytoplasm of clear cells contains large amounts of
glycogen and many
mitochondria.
Melanocytes appear as clear cells when in the
stratum basale
The ''stratum basale'' (basal layer, sometimes referred to as ''stratum germinativum'') is the deepest layer of the five layers of the epidermis, the external covering of skin in mammals.
The ''stratum basale'' is a single layer of columnar or ...
of the
skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.
Other animal coverings, such as the arthropod exoskeleton, have different de ...
, and
Langerhans' cells appear as clear cells in the
stratum spinosum
The stratum spinosum (or spinous layer/prickle cell layer) is a layer of the epidermis found between the stratum granulosum and stratum basale. This layer is composed of polyhedral keratinocytes. These are joined with desmosomes. Their spiny (La ...
.
C cells, more commonly referred to as
parafollicular cells are type of cell found in the thyroid gland which stain clear using H&E.
Clear cell cancers
Clear-cell adenocarcinoma
Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells.
Types include:
* Clear-cell adenocarcinoma of the vagina
* Clear-cell ovarian carcinoma
* Uterine clear-cell carcinoma
Uterine clear-cell carcinoma (CC) is a rare ...
s are
adenocarcinomas that contain a preponderance of clear cells.
References
{{reflist
Tissues (biology)
Secretory cells