Cedar virus, officially ''Cedar henipavirus'', is a henipavirus known to be harboured by ''
Pteropus spp''. Infectious virus was isolated from the urine of a mixed ''
Pteropus alecto
The black flying fox or black fruit bat (''Pteropus alecto'') is a bat in the family Pteropodidae. It is among the largest bats in the world, but is considerably smaller than the largest species in its genus, ''Pteropus''. The black flying fox ...
'' and ''
P. poliocephalus'' in
Queensland, Australia
)
, nickname = Sunshine State
, image_map = Queensland in Australia.svg
, map_caption = Location of Queensland in Australia
, subdivision_type = Country
, subdivision_name = Australia
, established_title = Before federation
, established_ ...
in 2009. Unlike the Nipah and Hendra virus, Cedar virus infection does not lead to obvious disease ''in vivo''. Infected animals mounted effective immune responses and seroconverted in challenge studies.
Unlike Hendra and Nipah, which attach to
Ephrin B2
Ephrin-B2 is a protein that in humans is encoded by the ''EFNB2'' gene.
Function
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases a ...
or
B3, Cedar virus can also attach to
Ephrin B1
Ephrin B1 is a protein that in humans is encoded by the ''EFNB1'' gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhes ...
. This may be responsible for lack of observed pathogenicity or development of severe meningoencephalitis and spinal inflammation. However the atypical course of disease observed in Cedar virus infection, as opposed to the characteristic immunopathology among the prototypic Nipah-Hendra complex, may be related to Cedar virus' reduced ability to access the key immunomodulatory gene products, V, W, and C, embedded in the henipavirus phosphoprotein P.
References
{{Taxonbar, from=Q24808808
Henipavirus
Paramyxoviridae