Cullin-2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''CUL2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
CUL2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CAND1
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the ''CAND1'' gene.
Interactions
CAND1 has been shown to interact with:
* CUL1,
* CUL2,
* CUL3,
* CUL4A,
* CUL4B,
* DCUN1D1
DCN1-like protein 1 is a ...
,
* DCUN1D1
DCN1-like protein 1 is a protein that in humans is encoded by the ''DCUN1D1'' gene.
DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.
Interactions
DCUN1D1 has bee ...
,
* RBX1
RING-box protein 1 is a protein that in humans is encoded by the ''RBX1'' gene.
Function
This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heter ...
,
* SAP130
Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the ''SAP130'' gene.
Function
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleische ...
,
* TCEB2
Elongin B is a protein that in humans is encoded by the ''ELOB'' gene.
Function
Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymer ...
and
* Von Hippel-Lindau tumor suppressor
The term ''von'' () is used in German language surnames either as a nobiliary particle indicating a noble patrilineality, or as a simple preposition used by commoners that means ''of'' or ''from''.
Nobility directories like the ''Almanach de ...
.
References
External links
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Further reading
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