Cleavage stimulation factor 50 kDa subunit is a
protein that in humans is encoded by the ''CSTF1''
gene.
This gene encodes one of three subunits which combine to form
cleavage stimulation factor Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a protein trimer, heterotrimeric protein, made up of the proteins CSTF1 (55kilodalton, kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the ...
(CSTF). CSTF is involved in the
polyadenylation
Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In euk ...
and 3' end cleavage of
pre-mRNAs. Similar to mammalian
G protein beta subunit
The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, c ...
s, this protein contains
transducin-like repeat
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Tandem copies of these repeats typically fold togethe ...
s. Several transcript variants with different
5' UTR
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of ...
, but encoding the same protein, have been found for this gene.
Interactions
CSTF1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
BARD1.
References
External links
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Further reading
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