Introduction

Complex Proteins Associated with

Set1 Set1 is a gene that codes for Histone-lysine N-methyltransferase and H3 lysine-4 specific proteins ( H3K). Set1 proteins can also be referred to as COMPASS proteins. The first H3K4 methylase, ''Saccharomyces cerevisiae'' Set1/COMPASS, is highly cons ...

, also known as COMPASS, is a conserved

protein complex A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multienzyme complexes, in which multiple catalytic domains are found in a single polypeptide chain. Protein c ...

playing a major role as a

H3K4me3 H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone H3 protein and is often involved in the regulation of gene expression. The name denotes the add ...

methylase Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features. The most common class of methyltransferases is class I, all of which contain a Rossm ...

eukaryote Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...

s. Since it was first identified in 2001, other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. The Compass complex, or similar protein complexes, have been identified in species ranging from single celled fungi to humans. They play an important regulatory role in many invaluable biological processes including DNA repair, the progression of the cell cycle and transcription through the methylenation of histone lysines. The COMPASS complex is an example of a

trithorax-group protein Trithorax-group proteins (TrxG) are a heterogeneous collection of proteins whose main action is to maintain gene expression. They can be categorized into three general classes based on molecular function: # histone-modifying TrxG proteins # chroma ...

. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The gene Cps50 coordinates the construction of COMPASS.

References

Protein complexes {{Protein-stub