Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of
intracellular pH
Intracellular pH (pHi) is the measure of the acidity or basicity (i.e., pH) of intracellular fluid. The pHi plays a critical role in membrane transport and other intracellular processes. In an environment with the improper pHi, biological cells m ...
, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the ''clic4'' gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated i
angiogenesispulmonary hypertensioncancer
an
cardioprotection from ischemia-reperfusion injury
They exhibit an intracellular vesicular pattern in PANC-1 PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of Ductal cells, ductal cell origin.
PANC-1 was derived from the tissue of a 56-year-old male. The cells can metastasis, metastasize but have poor differentiation a ...
cells (pancreatic cancer cells).
Binding partners
CLIC4 binds to dynamin
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamin is part of the " dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin ...
I, α-tubulin
Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytosk ...
, β-actin
Actin is a protein family, family of Globular protein, globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in myofibril, muscle fibrils. It is found in essentially all Eukaryote, eukaryotic cel ...
, creatine kinase
Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme () expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phos ...
and two 14-3-3 isoforms.
See also
* Chloride channel
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Several ...
References
Further reading
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External links
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Ion channels
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