Cadherin-15 is a
protein that in humans is encoded by the ''CDH15''
gene.
Function
This gene is a member of the
cadherin
Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to allow cells to adhere to each other . Cadherins are a class of type-1 transmembrane proteins, ...
superfamily of genes, encoding calcium-dependent intercellular adhesion
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
s. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in
myoblasts and upregulated in
myotubule-forming cells. The protein is thought to be essential for the control of
morphogenetic
Morphogenesis (from the Greek ''morphê'' shape and ''genesis'' creation, literally "the generation of form") is the biological process that causes a cell, tissue or organism to develop its shape. It is one of three fundamental aspects of deve ...
processes, specifically
myogenesis, and may provide a trigger for terminal muscle cell differentiation.
Interactions
CDH15 has been shown to
interact with
ARVCF
Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ''ARVCF'' gene.
Function
Armadillo repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family wh ...
.
References
Further reading
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External links
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