Cell division cycle 5-like protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''CDC5L''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene shares a significant similarity with ''
Schizosaccharomyces pombe
''Schizosaccharomyces pombe'', also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology. It is a unicellular eukaryote, whose cells are rod-shaped. Cells typically measur ...
'' cdc5 gene product, which is a
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA ( DNA replication) and some of its organelles, and sub ...
regulator important for
G2/
M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G
2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Interactions
CDC5L has been shown to
interact with:
*
ASF/SF2,
[
* BZW1,][
* CWC15,][
* ]DNA-PKcs
DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as ''PRKDC'' or ''XRCC7''. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ...
,[
* DYNC1H1,][
* GCN1L1,][
* HSPA8,][
* ILF2,][
* PLRG1,][
* PPP1CA,][
* ]PRPF19
Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the ''PRPF19'' gene.
In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair. upplied by OMIMref name="en ...
,[
* RBMX][ and
* RPL12,][
* RPL13,][
* RPS16,][
* RPS25,][
* SF3A1,][
* SF3B1,][
* ]SF3B2
Splicing factor 3B subunit 2 is a protein that in humans is encoded by the ''SF3B2'' gene.
Function
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit ...
,[
* ]SF3B4
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the ''SF3B4'' gene.
Function
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA imme ...
,[
* SFPQ,][
* ]SFRS2
Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the ''SFRS2'' gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promo ...
,[
* ]SNRPA1
U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the ''SNRPA1'' gene.
Interactions
SNRPA1 has been shown to interact with CDC5L.
References
Further reading
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,[
* SNRPD3,][
* ]SRRM1
Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the ''SRRM1'' gene.
Interactions
SRRM1 has been shown to Protein-protein interaction, interact with CDC5L.
References
Further reading
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...
,Small nuclear ribonucleoprotein D1
Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the ''SNRPD1'' gene.
Function
This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged pr ...
,[
* Small nuclear ribonucleoprotein D2,][
* ]Small nuclear ribonucleoprotein polypeptide A
U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the ''SNRPA'' gene.
Interactions
Small nuclear ribonucleoprotein polypeptide A has been shown to interact
Advocates for Informed Choice, dba interACT or int ...
,[
* TOP2A,][ and
* ]TTF2
Transcription termination factor 2 is a protein that in humans is encoded by the ''TTF2'' gene.
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein ...
.
See also
* G2/M checkpoint
References
Further reading
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External links
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{{PDB Gallery, geneid=988