Cell division cycle 5-like protein is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''CDC5L''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

The protein encoded by this gene shares a significant similarity with ''

Schizosaccharomyces pombe ''Schizosaccharomyces pombe'', also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology. It is a unicellular eukaryote, whose cells are rod-shaped. Cells typically meas ...

'' cdc5 gene product, which is a

cell cycle The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subs ...

regulator important for G₂/ M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G₂/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Interactions

CDC5L has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: *

ASF/SF2 Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the ''SRSF1'' gene. ASF/SF2 is an essential sequence specif ...

, *

BZW1 Basic leucine zipper and W2 domain-containing protein 1 is a protein that in humans is encoded by the ''BZW1'' gene. Interactions BZW1 has been shown to interact with PSTPIP1 and CDC5L Cell division cycle 5-like protein is a protein that in ...

, *

CWC15 Protein CWC15 homolog is a protein that in humans is encoded by the ''CWC15'' gene. Interactions CWC15 has been shown to interact with CDC5L Cell division cycle 5-like protein is a protein that in humans is encoded by the ''CDC5L'' gene. Fun ...

, *

DNA-PKcs DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as ''PRKDC'' or ''XRCC7''. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ...

, *

DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the ''DYNC1H1'' gene. Interactions DYNC1H1 has been shown to Protein-protein interaction, interact with PAFAH1B1 and CDC5L. Clinical relevance Mutations in this gene ha ...

, *

GCN1L1 Translational activator GCN1 is a protein that in humans is encoded by the ''GCN1L1'' gene. Interactions GCN1L1 has been shown to interact with CDC5L Cell division cycle 5-like protein is a protein that in humans is encoded by the ''CDC5L'' gen ...

, *

HSPA8 Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the ''HSPA8'' gene on chromosome 11. As a member of the heat shock protein 70 family and a chaperon ...

, *

ILF2 Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ''ILF2'' gene. Function Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT bin ...

, *

PLRG1 Pleiotropic regulator 1 is a protein that in humans is encoded by the ''PLRG1'' gene. Interactions PLRG1 has been shown to interact with CDC5L Cell division cycle 5-like protein is a protein that in humans is encoded by the ''CDC5L'' gene. ...

, *

PPM1D Protein phosphatase 1D is an enzyme that in humans is encoded by the ''PPM1D'' gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell ...

, *

PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the ''PPP1CA'' gene. Function The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP ...

, * PRPF19, *

RBMX Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the ''RBMX'' gene. Function This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chrom ...

and *

RPL12 60S ribosomal protein L12 is a protein that in humans is encoded by the ''RPL12'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits ar ...

, *

RPL13 60S ribosomal protein L13 is a protein that in humans is encoded by the ''RPL13'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are co ...

, *

RPS16 ''40S ribosomal protein S16 is a protein that in humans is encoded by the ''RPS16'' gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed o ...

, *

RPS25 40S ribosomal protein S25 (eS25) is a protein that in humans is encoded by the ''RPS25'' gene. Ribosomes are cellular macromolecules that catalyze protein synthesis across all kingdoms of life. The eukaryotic ribosome consists of a small 40S su ...

, *

SF3A1 Splicing factor 3 subunit 1 is a protein that in humans is encoded by the ''SF3A1'' gene. This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for ...

, *

SF3B1 Splicing factor 3B subunit 1 is a protein that in humans is encoded by the ''SF3B1'' gene. Function This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, ...

, *

SF3B2 Splicing factor 3B subunit 2 is a protein that in humans is encoded by the ''SF3B2'' gene. Function This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, ...

, *

SF3B4 Splicing factor 3B subunit 4 is a protein that in humans is encoded by the ''SF3B4'' gene. Function This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA imme ...

, *

SFPQ Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the ''SFPQ'' gene. Interactions SFPQ has been shown to interact with PTBP1, NONO, CDC5L and Ubiquitin C Polyubiquitin-C is a protein encoded by the ''UBC ...

, *

SFRS2 Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the ''SFRS2'' gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promote ...

, * SNRPA1, *

SNRPD3 Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the ''SNRPD3'' gene. Function The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splic ...

, *

SRRM1 Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the ''SRRM1'' gene. Interactions SRRM1 has been shown to interact with CDC5L Cell division cycle 5-like protein is a protein that in humans is encoded by th ...

, * Small nuclear ribonucleoprotein D1, *

Small nuclear ribonucleoprotein D2 Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the ''SNRPD2'' gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein b ...

, * Small nuclear ribonucleoprotein polypeptide A, *

TOP2A DNA topoisomerase IIα is a human enzyme encoded by the ''TOP2A'' gene. Topoisomerase IIα relives topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of ...

, and * TTF2.

References

External links

* {{PDB Gallery, geneid=988

Function

Interactions

See also

References

Further reading

External links