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Cell division cycle protein 27 homolog is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''CDC27''
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.


Function

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the
ubiquitin Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Fo ...
-mediated
proteolysis Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called protease ...
of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (
tetratricopeptide The tetratricopeptide repeat (TPR) is a structural motif. It consists of a Degeneracy (biology), degenerate 34 amino acid protein tandem repeats, tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motif ...
repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.


Interactions

CDC27 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with: * ANAPC10, *
ANAPC11 Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ''ANAPC11'' gene. Interactions ANAPC11 has been shown to interact with ANAPC2 Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ...
, *
ANAPC1 Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ''ANAPC1'' gene. ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cel ...
, *
ANAPC4 Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ''ANAPC4'' gene. A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating ...
, * ANAPC5, *
ANAPC7 Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat c ...
, *
CDC16 Cell division cycle protein 16 homolog is a protein that in humans is encoded by the ''CDC16'' gene. Function This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin li ...
, *
CDC20 The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the ''CDC20'' gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/ ...
, * CDC23, * CDH1, *
FZR1 Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the ''FZR1'' gene. Interactions FZR1 has been shown to interact with CDC27 and FBXO5 F-box only protein 5 is a protein that in humans is encoded by ...
, *
MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the ''MAD2L1'' gene. Function MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes ...
and *
PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the ''PIN1'' gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme bi ...
.


References


Further reading

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External links

* * {{PDBe-KB2, P30260, Cell division cycle protein 27 homolog