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Tetratricopeptide
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a Degeneracy (biology), degenerate 34 amino acid protein tandem repeats, tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These alpha-helix pair repeats usually protein folding, fold together to produce a single, linear solenoid protein domain, solenoid domain called a TPR domain. Proteins with such domains include the anaphase-promoting complex (APC) subunits CDC16, cdc16, CDC23, cdc23 and CDC27, cdc27, the NADPH oxidase subunit neutrophil cytosolic factor 2, p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins. Structure The structure of the PPP5C, PP5 protein w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TPR Motif Signature Residues
TPR may refer to: Businesses and organisations *The Pensions Regulator, a non-departmental public body of the United Kingdom *The Princeton Review, an American educational preparation company *Tapestry, Inc., an American clothing company (NYSE stock ticker: TPR) *Texas Public Radio Periodicals *''The Paris Review'', an American literary magazine *''Planetary Report'', the Planetary Society's magazine about space exploration *''Town Planning Review'', a journal published by Liverpool University Press Science and technology Medicine *Tetratricopeptide repeat, a degenerate protein sequence *Total pelvic rest, an obstetric prescription for placenta previa to avoid objects in the vagina *Total peripheral resistance, the cumulative resistance of arterioles *Translocated promoter region, part of a cancer-causing protein Other uses in science and technology *Temperature-programmed reduction *Thermoplastic elastomer, Thermoplastic rubber, a mixed polymer material *Total physica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TPR Repeats
TPR may refer to: Businesses and organisations *The Pensions Regulator, a non-departmental public body of the United Kingdom *The Princeton Review, an American educational preparation company * Tapestry, Inc., an American clothing company (NYSE stock ticker: TPR) *Texas Public Radio Periodicals *''The Paris Review'', an American literary magazine *'' Planetary Report'', the Planetary Society's magazine about space exploration *''Town Planning Review'', a journal published by Liverpool University Press Science and technology Medicine *Tetratricopeptide repeat, a degenerate protein sequence *Total pelvic rest, an obstetric prescription for placenta previa to avoid objects in the vagina *Total peripheral resistance, the cumulative resistance of arterioles * Translocated promoter region, part of a cancer-causing protein Other uses in science and technology * Temperature-programmed reduction * Thermoplastic rubber, a mixed polymer material *Total physical response, a langua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Motif
In a polymer, chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a common Biomolecular structure#Tertiary structure, three-dimensional structure that appears in a variety of different, evolutionarily unrelated molecules. A structural motif does not have to be associated with a sequence motif; it can be represented by different and completely unrelated sequences in different proteins or RNA. In nucleic acids Depending upon the sequence and other conditions, nucleic acids can form a variety of structural motifs which is thought to have biological significance. ;Stem-loop: Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop. The re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNAJC7
DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the ''DNAJC7'' gene. Interactions DNAJC7 has been shown to interact with RAD9A Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the ''RAD9A'' gene.''Rad9'' has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. ''Rad9'' was originally found in buddin .... References Further reading * * * * * * * * * * Heat shock proteins {{gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNAJC3
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the ''DNAJC3'' gene. Function The protein encoded by this gene contains multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). Clinical significance The DNAJC3 protein is an important apoptotic constituent. During a normal embryologic processes, or during cell injury (such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and fragmentation of the DNA and nucleus. This is followed by fragmentation into apoptotic bodies that are quickly removed by phagocytes, thereby preventing an inflammatory re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CTR9
RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the ''CTR9'' gene. Model organisms Model organisms have been used in the study of CTR9 function. A conditional knockout mouse line called ''Ctr9tm1b(EUCOMM)Wtsi'' was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ... to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping References External links * Further reading * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNOT10
CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. It is a subunit of the CCR4-Not Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The com ... deadenylase complex. References Further reading * {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CABIN1
Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the ''CABIN1'' gene. Function Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined. Interactions CABIN1 has been shown to interact with: * Amphiphysin, * MEF2B, * MEF2D, and * SIN3A Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the ''SIN3A'' gene. Function The protein encoded by this gene is a transcriptional regulatory protein. It conta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBS4
Bardet–Biedl syndrome 4 is a protein that in humans is encoded by the ''BBS4'' gene. This gene encodes a protein which contains tetratricopeptide repeats (TPR), similar to O-linked N-acetylglucosamine transferase. Mutations in this gene have been observed in patients with Bardet–Biedl syndrome type 4. The encoded protein may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. Interactions BBS4 has been shown to interact with DCTN1 Dynactin subunit 1 is a protein that in humans is encoded by the ''DCTN1'' gene. Function This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to .... References Further reading * * * * * * * * External links GeneReviews/NIH/NCBI/UW entry on Bardet-Biedl Syndrome * {{gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Interactions ANAPC7 has been shown to interact with ANAPC1, ANAPC4, CDC27 and CDC20 The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the ''CDC20'' gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AAG2
AAG may refer to: * Ambrak language, a Torricelli language of Papua New Guinea * Assistant adjutant general, a military title * United States Assistant Attorney General, a ranking within the Department of Justice Business * American Advisors Group * American Airlines Group Film and television * ''Aag'' (1948 film), a 1948 Bollywood film * ''Aag'' (1994 film), a 1994 Bollywood film * ''Aag'' (2007 film), a 2007 Bollywood film * AAG TV, a Pakistani TV channel Medicine * Acute angle closure glaucoma * alpha-1-acid glycoprotein, also referred to as Orosomucoid (ORM) * alkyladenine glycosylase; see Deamination * Autoimmune autonomic ganglionopathy * AAG, a codon for the amino acid lysine Organizations * American Association of Geographers * Association of Applied Geochemists * Athletics Association of Guyana Technology * AAG (cable system), an undersea cable system linking South East Asia with the United States of America * Advanced Arresting Gear, an aircraft arresting sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neutrophil Cytosolic Factor 2
Neutrophil cytosol factor 2 is a protein that in humans is encoded by the ''NCF2'' gene. Function This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reacti .... References Further reading * * * * * * * * * * * * * * * * * External links * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
