BioSentinel is a lowcost

CubeSat A CubeSat is a class of miniaturized satellite based around a form factor consisting of cubes. CubeSats have a mass of no more than per unit, and often use commercial off-the-shelf (COTS) components for their electronics and structure. CubeSats ...

spacecraft on a

astrobiology Astrobiology, and the related field of exobiology, is an interdisciplinary scientific field that studies the origins, early evolution, distribution, and future of life in the universe. Astrobiology is the multidisciplinary field that investig ...

mission that will use budding

yeast Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to constitut ...

to detect, measure, and compare the impact of deep space radiation on

DNA repair DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA dam ...

over long time beyond

low Earth orbit A low Earth orbit (LEO) is an orbit around Earth with a period of 128 minutes or less (making at least 11.25 orbits per day) and an eccentricity less than 0.25. Most of the artificial objects in outer space are in LEO, with an altitude never mor ...

. Selected in 2013 for a 2022 launch, the spacecraft will operate in the deep space radiation environment throughout its 18-month mission. This will help scientists understand the

health threat from cosmic rays Health threats from cosmic rays are the dangers posed by cosmic rays to astronauts on interplanetary missions or any missions that venture through the Van-Allen Belts or outside the Earth's magnetosphere. They are one of the greatest barriers ...

and deep space environment on living

organism In biology, an organism () is any living system that functions as an individual entity. All organisms are composed of cells (cell theory). Organisms are classified by taxonomy into groups such as multicellular animals, plants, and ...

s and reduce the risk associated with long-term human exploration, as

NASA The National Aeronautics and Space Administration (NASA ) is an independent agency of the US federal government responsible for the civil space program, aeronautics research, and space research. NASA was established in 1958, succeeding t ...

plans to send humans farther into space than ever before. The spacecraft has been launched on 16 November 2022 as part of the

Artemis 1 Artemis 1, officially Artemis I and formerly Exploration Mission-1 (EM-1), was an uncrewed Moon-orbiting mission. As the first major spaceflight of NASA's Artemis program, Artemis 1 marked the return of the agency to lunar exploration original ...

mission. The mission is being developed by

Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) laborat ...

Background

BioSentinel is one of ten low-cost

missions that flew as secondary payloads aboard

, the first test flight of NASA's

Space Launch System The Space Launch System (SLS) is an American super heavy-lift expendable launch vehicle developed by NASA. As of 2022, SLS has the highest payload capacity of any rocket in operational service, as well as the greatest liftoff thrust of any r ...

. The spacecraft was deployed in cis-lunar space as NASA's first mission to send living organisms beyond

since

Apollo 17 Apollo 17 (December 7–19, 1972) was the final mission of NASA's Apollo program, the most recent time humans have set foot on the Moon or traveled beyond low Earth orbit. Commander Gene Cernan and Lunar Module Pilot Harrison Schmitt walked on ...

in 1972.

Objective

The primary objective of BioSentinel is to develop a biosensor using a simple model organism (

) to detect, measure, and correlate the impact of

space radiation Health threats from cosmic rays are the dangers posed by cosmic rays to astronauts on interplanetary missions or any missions that venture through the Van-Allen Belts or outside the Earth's magnetosphere. They are one of the greatest barriers ...

to living organisms over long durations beyond

(LEO) and into heliocentric orbit. While progress has been made with simulations, no terrestrial laboratory can duplicate the unique space radiation environment.

Biological science

The BioSentinel biosensor uses the budding

Saccharomyces cerevisiae ''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...

'' to detect and measure

DNA damage DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA da ...

response after exposure to the deep space radiation environment. Two yeast strains were selected for this mission: a wild type strain proficient in DNA repair, and a strain defective in the repair of DNA double strand breaks (DSBs), deleterious lesions generated by ionizing radiation. Budding yeast was selected not only because of its flight heritage, but also because of its similarities with human cells, especially its DSB repair mechanisms. The biosensor consists of specifically engineered yeast strains and growth medium containing a metabolic indicator dye. Therefore, culture growth and metabolic activity of yeast cells directly indicate successful repair of DNA damage. After completing the Moon flyby and spacecraft checkout, the science mission phase will begin with the wetting of the first set of yeast-containing wells with specialized media. Multiple sets of wells will be activated at different time points over the 18-month mission. One reserve set of wells will be activated in the occurrence of a

solar particle event In solar physics, a solar particle event (SPE), also known as a solar energetic particle (SEP) event or solar radiation storm, is a solar phenomenon which occurs when particles emitted by the Sun, mostly protons, become accelerated either in th ...

(SPE). Approximately, a 4 to 5 krad total ionizing dose is anticipated. Payload science data and spacecraft telemetry will be stored on board and then downloaded to the ground. Biological measurements will be compared to data provided by onboard radiation sensors and dosimeters. Additionally, two identical BioSentinel payloads have been developed: one for the

International Space Station The International Space Station (ISS) is the largest modular space station currently in low Earth orbit. It is a multinational collaborative project involving five participating space agencies: NASA (United States), Roscosmos (Russia), JAXA ...

(ISS), which is in similar

microgravity The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the I ...

conditions but a comparatively low-radiation environment, and one for use as a delayed-synchronous ground control at Earth gravity and, due to

Earth's magnetic field Earth's magnetic field, also known as the geomagnetic field, is the magnetic field that extends from Earth's interior out into space, where it interacts with the solar wind, a stream of charged particles emanating from the Sun. The magnetic f ...

, at Earth-surface-level radiation. The payload on the ISS has been warmed up and rehydrated in January 2022, the one on Earth surface, weeks later. They will help calibrate the biological effects of radiation in deep space to analogous measurements conducted on Earth and on the ISS.

Spacecraft

The Biosentinel spacecraft will consist of a 6U

bus A bus (contracted from omnibus, with variants multibus, motorbus, autobus, etc.) is a road vehicle that carries significantly more passengers than an average car or van. It is most commonly used in public transport, but is also in use for cha ...

format, with external dimensions of 10 cm × 20 cm × 30 cm and a mass of about . At launch, BioSentinel resides within the second stage on the launch vehicle from which it is deployed to a lunar flyby trajectory and into an Earth-trailing

heliocentric Heliocentrism (also known as the Heliocentric model) is the astronomical model in which the Earth and planets revolve around the Sun at the center of the universe. Historically, heliocentrism was opposed to geocentrism, which placed the Earth at ...

orbit. Of the total 6 Units volume, 4 Units will hold the science payload, including a radiation dosimeter and a dedicated 3-color

spectrometer A spectrometer () is a scientific instrument used to separate and measure spectral components of a physical phenomenon. Spectrometer is a broad term often used to describe instruments that measure a continuous variable of a phenomenon where the ...

for each well; 0.5U will house the ADCS (Attitude Determination and Control Subsystem), 0.5U will house the EPS (Electrical Power System) and C&DH (Command and Data Handling) avionics, and 1U will house the

attitude control Attitude control is the process of controlling the orientation of an aerospace vehicle with respect to an inertial frame of reference or another entity such as the celestial sphere, certain fields, and nearby objects, etc. Controlling vehicle ...

thruster assembly, which will be 3D printed all in one piece: cold gas (DuPont R236fa) propellant tanks, lines and seven nozzles. The use of 3D printing also allows the optimization of space for increased propellant storage (165 grams ). The thrust of each nozzle is 50 mN, and a specific impulse of 31 seconds. The attitude control system is being developed and fabricated by the

Georgia Institute of Technology The Georgia Institute of Technology, commonly referred to as Georgia Tech or, in the state of Georgia, as Tech or The Institute, is a public research university and institute of technology in Atlanta, Georgia. Established in 1885, it is part of ...

. Electric power will be generated by deployable

solar panels A solar cell panel, solar electric panel, photo-voltaic (PV) module, PV panel or solar panel is an assembly of photovoltaic solar cells mounted in a (usually rectangular) frame, and a neatly organised collection of PV panels is called a phot ...

rated at 30

watt The watt (symbol: W) is the unit of power or radiant flux in the International System of Units (SI), equal to 1 joule per second or 1 kg⋅m2⋅s−3. It is used to quantify the rate of energy transfer. The watt is named after James Wa ...

s, and

telecommunication Telecommunication is the transmission of information by various types of technologies over wire, radio, optical, or other electromagnetic systems. It has its origin in the desire of humans for communication over a distance greater than that fe ...

s will rely on the Iris transponder at

X-band The X band is the designation for a band of frequencies in the microwave radio region of the electromagnetic spectrum. In some cases, such as in communication engineering, the frequency range of the X band is rather indefinitely set at approxi ...

. The spacecraft is being developed by NASA

(AMR), in collaboration with NASA

Jet Propulsion Laboratory The Jet Propulsion Laboratory (JPL) is a federally funded research and development center and NASA field center in the City of La Cañada Flintridge, California, United States. Founded in the 1930s by Caltech researchers, JPL is owned by NASA an ...

(JPL), NASA

Johnson Space Center The Lyndon B. Johnson Space Center (JSC) is NASA's center for human spaceflight (originally named the Manned Spacecraft Center), where human spaceflight training, research, and flight control are conducted. It was renamed in honor of the late U ...

(JSC), NASA

Marshall Space Flight Center The George C. Marshall Space Flight Center (MSFC), located in Redstone Arsenal, Alabama (Huntsville postal address), is the U.S. government's civilian rocketry and spacecraft propulsion research center. As the largest NASA center, MSFC's first ...

(MSFC), and

NASA Headquarters NASA Headquarters, officially known as Mary W. Jackson NASA Headquarters or NASA HQ and formerly named Two Independence Square, is a low-rise office building in the two-building Independence Square complex at 300 E Street SW in Washington, D.C. ...

References

External links

Fact Sheet of BioSentinel
at NASA {{Orbital launches in 2022 CubeSats DNA repair Space exposure experiments Space-flown life 2022 in the United States Spacecraft launched in 2022 NASA space probes Astrobiology space missions Secondary payloads