Barbara Mary Frances Pearse FRS (born 24 March 1948,

Wraysbury Wraysbury is a village and civil parish in the Royal Borough of Windsor and Maidenhead in England. It is under the western approach path of London Heathrow airport. It is located on the east bank of the River Thames, roughly midway between Wind ...

Buckinghamshire Buckinghamshire (), abbreviated Bucks, is a ceremonial county in South East England that borders Greater London to the south-east, Berkshire to the south, Oxfordshire to the west, Northamptonshire to the north, Bedfordshire to the north-east ...

, England) is a British biological scientist. She works at the Medical Research Council

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical ...

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge becam ...

, United Kingdom.

Education

Barbara Pearse attended the independent Lady Eleanor Holles School in

Hampton Hampton may refer to: Places Australia * Hampton bioregion, an IBRA biogeographic region in Western Australia * Hampton, New South Wales * Hampton, Queensland, a town in the Toowoomba Region * Hampton, Victoria Canada *Hampton, New Brunswick * ...

in Greater London, and gained her undergraduate degree from

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = � ...

in 1969.

Career

She was appointed to the scientific staff of the MRC Laboratory of Molecular Biology in 1982.

Research

Pearse's main contributions lie in the structure of coated

vesicle Vesicle may refer to: ; In cellular biology or chemistry * Vesicle (biology and chemistry), a supramolecular assembly of lipid molecules, like a cell membrane * Synaptic vesicle ; In human embryology * Vesicle (embryology), bulge-like features o ...

s. Pearse first purified coated vesicles; she also discovered the

clathrin Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. W ...

coat molecule in 1975. Coated pits and vesicles were first seen in thin sections of tissue in the electron microscope by Thomas Roth and Keith Porter in 1964. The importance of them for the clearance of

LDL Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall densi ...

from blood was discovered by R. G. Anderson,

Michael S. Brown Michael Stuart Brown ForMemRS NAS AAA&S APS (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of choles ...

and

Joseph L. Goldstein Joseph Leonard Goldstein ForMemRS (born April 18, 1940) is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies ...

in 1976.

Awards and honours

She was visiting professor in

cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living a ...

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considere ...

(1984-5). She was elected a member of

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

(EMBO) in 1982 and awarded the

EMBO Gold Medal The EMBO Gold Medal is an annual award of the European Molecular Biology Organization (EMBO) given to young scientists for outstanding contributions to the life sciences in Europe. Laureates receive a medal and €10,000 and are invited to rece ...

in 1987. She was elected a Fellow of the Royal Society in 1988.

Personal life

She is married to

Mark Bretscher Mark Steven Bretscher (born 8 January 1940) is a British biological scientist and Fellow of the Royal Society. He worked at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom and is currently retired. Educa ...

, another scientist.

References

{{DEFAULTSORT:Pearse, Barbara 1948 births 20th-century British biologists 20th-century British women scientists 21st-century British biologists 21st-century British women scientists Academics of the University of Cambridge Academics of University College London Alumni of University College London British women biologists Fellows of the Royal Society Female Fellows of the Royal Society Living people Members of the European Molecular Biology Organization People educated at Lady Eleanor Holles School People from Buckinghamshire People from the Royal Borough of Windsor and Maidenhead Stanford University faculty