Bromodomain adjacent to zinc finger domain protein 1A is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the ''BAZ1A''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

Structure

The

encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs: * N-terminus –

PHD finger PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper ''Piled Higher and Deeper'' (also known as ''PhD Comics''), is a newsp ...

(C4HC3

zinc finger A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized struct ...

) * WAKZ motif * LH ( leucine-rich helical domain) motif * C-terminus – bromodomain

Function

BAZ1A along with

SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the ''SMARCA5'' gene. Function The protein encoded by this gene is a member of the ISWI family of proteins. ...

POLE3 DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the ''POLE3'' gene. POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protei ...

, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex. The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent. Furthermore, the BAZ1A-SMARCA5 complex enables

DNA replication In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritanc ...

through highly condensed regions of

chromatin Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in r ...

Interactions

BAZ1A has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

and

SATB1 SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the ''SATB1'' gene. Function SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chro ...

References

Genes on human chromosome 14 {{Gene-14-stub