The Bristol Myers Squibb Company (BMS) is an American multinational

pharmaceutical company The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate sympto ...

. Headquartered in

New York City New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the Un ...

, BMS is one of the world's largest pharmaceutical companies and consistently ranks on the ''Fortune'' 500 list of the largest U.S. corporations. For

fiscal Fiscal usually refers to government finance. In this context, it may refer to: Economics * Fiscal policy, use of government expenditure to influence economic development * Fiscal policy debate * Fiscal adjustment, a reduction in the government ...

2021, it had a total revenue of $46.4 billion. Bristol Myers Squibb manufactures prescription pharmaceuticals and biologics in several therapeutic areas, including

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...

, cardiovascular disease,

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...

hepatitis Hepatitis is inflammation of the liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes ( jaundice), poor appetite, vomiting, tiredness, abdominal ...

rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are invol ...

, and

psychiatric disorders A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. Such features may be persistent, relapsing and remitti ...

. BMS's primary research and development (R&D) sites are located in Lawrence, New Jersey (formerly Squibb, near

Princeton Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ni ...

), Summit, New Jersey, formerly HQ of

Celgene Celgene Corporation is a pharmaceutical company that makes cancer and immunology drugs. Its major product is Revlimid ( lenalidomide), which is used in the treatment of multiple myeloma, and also in certain anemias. The company is incorporated i ...

, New Brunswick, New Jersey,

Redwood City, California Redwood City is a city on the San Francisco Peninsula in Northern California's Bay Area, approximately south of San Francisco, and northwest of San Jose. Redwood City's history spans its earliest inhabitation by the Ohlone people to being a ...

, and

Seville Seville (; es, Sevilla, ) is the capital and largest city of the Spanish autonomous community of Andalusia and the province of Seville. It is situated on the lower reaches of the River Guadalquivir, in the southwest of the Iberian Peninsula ...

in Spain, with other sites in Devens and

Cambridge, Massachusetts Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. As part of the Boston metropolitan area, the cities population of the 2020 U.S. census was 118,403, making it the fourth most populous city in the state, behind Boston ...

East Syracuse, New York East Syracuse is an incorporated village and a suburb of the City of Syracuse in eastern Onondaga County, New York, United States. As of the 2010 U.S. census, the village had a population of 3,084. It is located immediately east of Syracuse, i ...

, Braine-l'Alleud, Belgium,

Tokyo, Japan Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, with an estimated 37.468 ...

Bangalore, India Bangalore (), officially Bengaluru (), is the capital and largest city of the Indian state of Karnataka. It has a population of more than and a metropolitan population of around , making it the third most populous city and fifth most ...

, and Wirral, United Kingdom. BMS previously had an R&D site in

Wallingford, Connecticut Wallingford is a town in New Haven County, Connecticut, United States, centrally located between New Haven and Hartford, and Boston and New York City. The population was 44,396 at the 2020 census. The community was named after Wallingford, in En ...

(formerly Bristol-Myers).

History

Squibb

The Squibb corporation was founded in 1858 by Edward Robinson Squibb in

Brooklyn Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York. Kings County is the most populous county in the State of New York, and the second-most densely populated county in the United States, be ...

, New York. Squibb was known as an advocate of quality control and high purity standards early within the pharmaceutical industry. He went on to self-publish an alternative to the

U.S. Pharmacopeia The ''United States Pharmacopeia'' (''USP'') is a pharmacopeia (compendium of drug information) for the United States published annually by the United States Pharmacopeial Convention (usually also called the USP), a nonprofit organization that ...

titled ''Squibb's Ephemeris of Materia Medica,'' after failing to convince the

American Medical Association The American Medical Association (AMA) is a professional association and lobbying group of physicians and medical students. Founded in 1847, it is headquartered in Chicago, Illinois. Membership was approximately 240,000 in 2016. The AMA's sta ...

to incorporate higher purity standards. ''Materia Medica'', Squibb products, and Edward Squibb's opinion on the fundamentals of pharmacy are found in many medical papers of the late 1800s. The '' American Journal of Pharmacy'' published more than one hundred papers of Squibb's research surrounding the industry. The sons of Edward Squibb sold the company to Lowell M. Palmer and Theodore Weicker in 1905, who incorporated the company. Around this time, the Squibb logo was developed, which represented the company's products of "uniformity, purity, efficacy, and reliability based on research." Squibb Corporation served as a major supplier of medical goods to the Union Army during the

American Civil War The American Civil War (April 12, 1861 – May 26, 1865; also known by other names) was a civil war in the United States. It was fought between the Union ("the North") and the Confederacy ("the South"), the latter formed by states ...

, providing portable medical kits containing

morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...

, surgical anesthetics, and

quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to '' Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal le ...

for the treatment of malaria (which was endemic in most of the Eastern United States at that time). In 1944, Squibb opened the world's largest penicillin plant in New Brunswick, New Jersey.

Bristol-Myers

In 1887,

Hamilton College Hamilton College is a private liberal arts college in Clinton, Oneida County, New York. It was founded as Hamilton-Oneida Academy in 1793 and was chartered as Hamilton College in 1812 in honor of inaugural trustee Alexander Hamilton, following ...

graduates William McLaren Bristol and John Ripley Myers purchased the Clinton Pharmaceutical company of Clinton, New York. In May 1898, they decided to rename it Bristol, Myers and Company. Following Myers' death in 1899, Bristol changed the name to the Bristol-Myers Corporation. During the 1890s, the company introduced its first nationally recognized product

Sal Hepatica Sal Hepatica is the name of a mineral salt laxative that was produced and marketed by Bristol-Myers from its inception in 1887, becoming its first nationally recognized product in 1903, until 1958. When dissolved in water, it was said to reproduce ...

, a

laxative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...

mineral salt, followed by

Ipana Ipana was a toothpaste product manufactured by Bristol-Myers Company. The wintergreen flavored toothpaste (0.243% sodium fluoride was its active ingredient) reached its peak market penetration during the 1950s in North America. Marketing of Ipan ...

toothpaste in 1901.Bert Rosenbloom, ''Marketing Channels''
Bristol-Myers Squibb
, 2011, page 609 Other divisions were

Clairol Clairol is the American personal care-product division of company Wella, specializing in hair coloring and hair care. Clairol was founded in 1931 by Americans Joan Gelb and her husband Lawrence M. Gelb, with business partner and lifelong frien ...

(hair colors and haircare) and

Drackett The Drackett Company was a leading company in the specialty chemicals business during the 20th century, responsible for such products as Windex glass cleaner, Vanish toilet bowl cleaner, Drāno drain opener, Behold furniture polish, Endust ...

(household products such as

Windex Windex is an American brand of glass and hard-surface cleaner that was invented by the Drackett Company in 1933 and has been marketed throughout the intervening decades—originally in glass containers, later in plastic ones. Drackett sold the W ...

and

Drano Drano (styled as Drāno) is an American brand of chemical drain cleaner that is manufactured by S. C. Johnson & Son. Crystal Drano According to the National Institutes of Health's Household Products Database, the crystal form is composed of: ...

). In 1943, Bristol-Myers acquired Cheplin Biological Laboratories, a producer of acidophilus milk in

, and converted the plant to produce penicillin for the World War II Allied forces. After the war, the company renamed the plant Bristol Laboratories in 1945 and entered the civilian

antibiotics An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention o ...

market, where it faced competition from Squibb. Penicillin production at the East Syracuse plant ended in 2005, when it became less expensive to produce overseas. As of 2010, the facility was used for the manufacturing process development and production of other biologic medicines for clinical trials and commercial use.

Merger

In 1989, Bristol-Myers and Squibb merged and became Bristol-Myers Squibb. In 1999, then-U.S. President Bill Clinton awarded Bristol-Myers Squibb the

National Medal of Technology The National Medal of Technology and Innovation (formerly the National Medal of Technology) is an honor granted by the President of the United States to American inventors and innovators who have made significant contributions to the development ...

, the nation's highest recognition for technological achievement, "for extending, and enhancing human life through innovative pharmaceutical research and development and for redefining the science of clinical study through groundbreaking and hugely complex clinical trials that are recognized models in the industry."

2000 to 2010

In 2002, the company was involved in a lawsuit of illegally maintaining a monopoly on Taxol, its cancer treatment, and it was again sued for the antitrust lawsuit 5 years later, which cost the company $125 million for settlement. Also in 2002, Bristol-Myers Squibb was involved in an

accounting scandal Accounting, also known as accountancy, is the measurement, processing, and communication of financial and non financial information about economic entities such as businesses and corporations. Accounting, which has been called the "languag ...

that resulted in a significant restatement of revenues from 1999 to 2001. The restatement was the result of an improper booking of sales related to " channel stuffing" as the practice of offering excess inventory to customers to create higher sales numbers. The company has since settled with the

United States Department of Justice The United States Department of Justice (DOJ), also known as the Justice Department, is a federal executive department of the United States government tasked with the enforcement of federal law and administration of justice in the United Stat ...

and Securities and Exchange Commission, agreeing to pay $150 million, while neither admitting nor denying guilt. On October 24, 2002, Bristol-Myers Squibb Co. restated earnings downward for parts of 2000 and 2001, while revising this year's earnings upward because of its massive inventory backlog imbroglio that spurred two government investigations. On March 15, 2004, Bristol-Myers Squibb Co. adjusted upward its fourth-quarter and full-year 2003 results after reversing an earlier decision about how to deal with accounting errors made in prior years. As part of a deferred prosecution agreement, the company was placed under the oversight of a monitor appointed by the U.S. attorney in w Jersey. In addition, the former head of the Pharma group, Richard Lane, and the ex-CFO, Fred Schiff, were indicted for federal securities violations. In July 2006, an investigation of the company was made public, and the

FBI The Federal Bureau of Investigation (FBI) is the domestic intelligence and security service of the United States and its principal federal law enforcement agency. Operating under the jurisdiction of the United States Department of Justice, t ...

raided the company's corporate offices. The investigation centered on the distribution of Plavix and charges of

collusion Collusion is a deceitful agreement or secret cooperation between two or more parties to limit open competition by deceiving, misleading or defrauding others of their legal right. Collusion is not always considered illegal. It can be used to att ...

. On September 12, 2006, the monitor, former Federal Judge

Frederick B. Lacey Frederick Bernard Lacey (September 9, 1920 – April 1, 2017) was a United States district judge of the United States District Court for the District of New Jersey. Education and career Lacey was born in Newark, New Jersey in 1920 to Frederic ...

, urged the company to remove then-CEO Peter Dolan over the Plavix dispute. Later that day, BMS announced that Dolan would indeed step down. The deferred prosecution agreement expired in June 2007 and the Department of Justice did not take any further legal action against the company for matters covered by the DPA. Under CEO Jim Cornelius, who was CEO following Dolan until May 2010, all executives involved in the "channel-stuffing" and generic competition scandals have since left the company. In 2009, the company began a major restructuring focusing on the pharmaceutical business and biologic products, along with productivity initiatives and cost-cutting and streamlining business operations through a multiyear program of on-going layoffs. This was part of a business strategy launched in 2007 to transform the company from a large, diversified pharmaceutical company to a specialty biopharma company, which also included the closure of half of their manufacturing facilities. As another cost-cutting measure, Bristol-Myers Squibb also reduced health-care subsidies for retirees and plans to freeze their pension plan at the end of 2009. BMS is a ''Fortune'' 500 Company (#114 in 2010 list). ''Newsweek's ''2009 Green Ranking recognized Bristol-Myers Squibb as eighth among 500 of the largest United States corporations. Also, BMS was included in the 2009 Dow Jones Sustainability North America Index of leading sustainability-driven companies. Lamberto Andreotti was named CEO in 2010; he had previously served as "president and COO responsible for all pharmaceutical operations worldwide."

2010 onward

Bristol Myers Squibb, Moreton, Wirral - IMG 0369

In 2010, Lou Schmukler joined Bristol-Myers Squibb as the president of global product development and design. Schmukler led the team that completed the company's strategic transformation to a specialty biopharmaceutical company that had begun in 2007. As of 2011, the company had a dozen manufacturing facilities and six product development sites. Citing major developments and a market capitalization of US$87 billion and stock appreciation of 61.4%, Bristol-Myers Squibb was ranked as the best drug company of 2013 by ''Forbes'' magazine. In December 2014, the company received FDA approval for the use of the

PD-1 Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regula ...

inhibitor

nivolumab Nivolumab, sold under the brand name Opdivo, is a medication used to treat a number of types of cancer. This includes melanoma, lung cancer, malignant pleural mesothelioma, renal cell carcinoma, Hodgkin lymphoma, head and neck cancer, urotheli ...

(Opdivo) in treating patients whose skin cancer cannot be removed or have not responded to previous drug therapies. In February 2015, the company initiated a research partnership with Rigel Pharmaceuticals which could generate more than $339 million. In March, the company obtained an exclusive opportunity to both licence and commercialise PROSTVAC, Bavarian Nordic's phase III prostate-specific antigen targeting cancer immunotherapy. Bavarian Nordic would receive an upfront payment of $60 million and incremental payments up to $230 million, if the overall survival of test patients exceeds that seen in Phase II tests. Bavarian could also receive milestone payments of between $110 million and $495 million, dependent on regulatory authorization, and these payments have the potential to total up to $975 million. In May 2015, Dr. Giovanni Caforio became CEO of the company; Caforio was formerly the company's COO and succeeded Andreotti upon his retirement. Andreotti subsequently succeeded James Cornelius as executive chairman upon his retirement. In late February 2017, ''

The Wall Street Journal ''The Wall Street Journal'' is an American business-focused, international daily newspaper based in New York City, with international editions also available in Chinese and Japanese. The ''Journal'', along with its Asian editions, is published ...

'' and '' Fortune'', among others, reported that activist investor

Carl Icahn Carl Celian Icahn (; born February 16, 1936) is an American financier. He is the founder and controlling shareholder of Icahn Enterprises, a public company and diversified conglomerate holding company based in Sunny Isles Beach. Icahn takes la ...

had taken a stake in the company, signaling a potential future takeover from the likes of

Gilead Sciences Gilead Sciences, Inc. () is an American biopharmaceutical company headquartered in Foster City, California, that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS, hepatitis B, hepatitis C, influenza, and C ...

. In April 2018, the company reported net income of $1.5 billion, or 91 cents per share, for the first quarter of the year, thanks to the increased sales of their cancer drug Opdivo.

Corporate acquisitions and divestments as Bristol Myers Squibb

In August 2009, during a major restructuring activity, BMS acquired the

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used ...

firm Medarex as part of the company's "String of Pearls" strategy of alliances, partnerships, and acquisitions. In November 2009, Bristol Myers Squibb announced that it was "splitting off" Mead Johnson Nutrition by offering BMY shareholders the opportunity to exchange their stock for shares in Mead Johnson. According to Bristol Myers Squibb, this move was expected to further sharpen the company's focus on biopharmaceuticals. In October 2010, the company acquired ZymoGenetics, securing an existing product, as well as pipeline assets in hepatitis C, cancer, and other therapeutic areas. Bristol Myers Squibb agreed to pay around $2.5 billion in cash to buy Inhibitex Inc. in attempt to compete with

Gilead Gilead or Gilad (; he, גִּלְעָד ''Gīləʿāḏ'', ar, جلعاد, Ǧalʻād, Jalaad) is the ancient, historic, biblical name of the mountainous northern part of the region of Transjordan.''Easton's Bible Dictionary'Galeed''/ref> ...

/ Pharmasset to produce hepatitis C drugs. The settlement will be finished in 2 months for its Inhibitex's shareholders acceptance of 126% premium price of its price over the previous 20 trading days ended on January 6. On June 29, BMS extended its portfolio of

treatments when it agreed to buy Amylin Pharmaceuticals for around in cash and pay to

Eli Lilly Eli Lilly (July 8, 1838 – June 6, 1898) was an American soldier, pharmacist, chemist, and businessman who founded the Eli Lilly and Company pharmaceutical corporation. Lilly enlisted in the Union Army during the American Civil War and ...

to cover Amylin's debt and its outstanding collaboration-related obligations.

AstraZeneca AstraZeneca plc () is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England. It has a portfolio of products for major diseases in areas includi ...

, which already collaborated on several diabetes treatments with BMS, agreed to pay US$3.4 billion in cash for the right to continue development of Amylin's products. Two years later, the company divested Amylin to AstraZeneca. In April 2014, BMS announced its acquisition of iPierian for up to $725 million. In February 2015, the company acquired Flexus Biosciences for $1.25 billion. As part of this deal, BMS will gain full rights to Flexus' lead small molecule IDO1-inhibitor, F001287. In November, the company acquired the cardiovascular disease drug developer Cardioxyl for up to $2.075 billion. The deal strengthens the BMS' critical pipelines with the phase II candidate for acute decompensated heart failure, CXL-1427. In March 2016, the company announced it would acquire Padlock Therapeutics for up to $600 million. In early July, the company announced it would acquire Cormorant Pharmaceuticals for $520 million, boosting BMS' oncology offering through Cormorants

monoclonal antibody A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies ...

targeted against

interleukin-8 Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage ...

. In August 2017 the company acquired

IFM Therapeutics IFM Therapeutics is a pharmaceutical company focused on developing biological treatments for autoimmune diseases. IFM Therapeutics launched in 2015 in Cambridge, Massachusetts, based on seed funding from the Boston-based venture capital fund Atl ...

for $300 million upfront, with contingency payments of $1.01 billion due on certain milestones – allowing BMS to better compete against Merck & Co's cancer rival treatment,

Keytruda Pembrolizumab, sold under the brand name Keytruda, is a humanized antibody used in cancer immunotherapy that treats melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, stomach cancer, cervical cancer, and certain types of breast canc ...

. In early January 2019, the company announced it would acquire

(NASDAQ:CELG) for $74 billion ($95 billion including debt), in a deal that would become the largest pharmaceutical-company acquisition ever. The Celgene acquisition aimed to be a refresher to the company's pipeline, helping to overcome from declining sales of Opdivo relative to competitor

. Under the terms of the deal, Celgene shareholders would receive one BMS share as well as $50 in cash for each Celgene share held, valuing Celgene at $102.43 a share; representing a 54% premium to the previous days closing price. Investor opposition to this acquisition, leading into an April 12 shareholder vote, appeared when BMS's second-largest investor,

Wellington Management Wellington Management Company is a private, independent investment management firm with client assets under management totaling over US$1 trillion based in Boston, Massachusetts, United States. The firm serves as an investment advisor to over ...

, voiced its opposition, followed by investor

Starboard Value Starboard Value is an American hedge fund that was founded in 2002 by Jeffrey Smith and Mark Mitchell with Smith serving as CEO.Butt, Rachel; Here are the 10 biggest activist money managers and some of their most impressive bets; Business Inside ...

. In April 2019 BMS announced that 75% of its shareholders voted to approve the pending merger with Celgene. Transaction to close in the third quarter of 2019, subject to regulatory approvals. Newly issued BMS shares and CVRs will commence trading on the New York Stock Exchange, with the CVRs trading under the symbol 'BMYRT'. The strategic divestment of the company's consumer health business, UPSA, to Taisho completed in 2019. UPSA focused product delivery on France and the rest of Europe. As early as 2005, the company had divested individual consumer products, and its US- and Canada-focused consumer products business. In August, the

Amgen Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. One of the world's largest independent biotechnology companies, Amgen was established in T ...

announced it would acquire the Otezla drug programme from

for $13.4 billion, as part of Celgene and BMS's merger deal. In February 2020, BMS and partner Biomotiv launched a new company called Anteros Pharmaceuticals, which focuses on creating inflammation and fibrosis medicines. In August, the business announced it would acquire Forbius and its

TGF-beta 1 Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other si ...

& TGF-beta 3 inhibitors. In October, BMS announced it would acquire cardiology company MyoKardia for $13.1 billion ($225 per share) gaining control of mavacamten, a cardiovascular drug for obstructive hypertrophic cardiomyopathy (HCM), and the development of two key treatments: danicamtiv (MYK-491) and MYK-224. In June 2022, BMS announced it would acquire Turning Point Therapeutics Inc for $4.1 billion in cash ($76 per share, a 122.5% premium to its last closing price), helping to boost its compliment of cancer drugs, specifically repotrectinib.

List of mergers and acquisitions

The following is an illustration of the company's major mergers and acquisitions and historical predecessors: *Bristol-Myers Squibb (Formed by the merger of Squibb Corporation (Est 1858) and Bristol-Myers (Est 1887)) ** Adnexus Therapeutics ** ConvaTec ** Kosan Biosciences ** Medarex (Acq 2009) ** ZymoGenetics (Acq 2010) ** Amira Pharmaceuticals ** Inhibitex Inc (Acq 2012) ** Amylin Pharmaceuticals (Acq 2012 jointly with

) ** iPierian (Acq 2014) ** Flexus Biosciences (Acq 2015) ** Cardioxyl (Acq 2015) ** Padlock Therapeutics (Acq 2016) ** Cormorant Pharmaceuticals (Acq 2016) **

(Acq 2017) **

(Acq 2019) *** Signal Pharmaceuticals, Inc (Acq 2000) *** Anthrogenesis (Acq 2002) *** Pharmion Corporation (Acq 2008) *** Gloucester Pharmaceuticals (Acq 2009) *** Abraxis BioScience Inc (Acq 2010) *** Avila Therapeutics, Inc (Acq 2012) *** Quanticel (Acq 2015) *** Receptos (Acq 2015) *** EngMab AG (Acq 2016) *** Delinia (Acq 2017) *** Impact Biomedicines (Acq 2018) *** Juno Therapeutics (Acq 2018) **** AbVitro (Acq 2016) **** RedoxTherapies (Acq 2016) ** Forbius (Acq 2020) ** MyoKardia (Acq 2020) ** Turning Point Therapeutics (Acq 2022)

Finances

For the fiscal year 2018,Bristol Myers Squibb reported earnings of US$1.007 billion, with an annual revenue of US$20.776 billion, an increase of 6.9% over the previous fiscal cycle. Bristol-Myers Squibb's shares traded at over $55 per share, and its market capitalization was valued at over US$81.6 billion in October 2018. In 2018, 85% of the company's revenues came from just five products. In 2018, Bristol-Myers Squibb spent 36% of its total revenue on R&D expenses. Bristol-Myers Squibb ranked 145th on the Fortune 500 list of the largest United States corporations by revenue in 2018.

Carbon footprint

Bristol Myers Squibb reported Total CO2e emissions (Direct + Indirect) for the twelve months ending 31 December 2020 at 278 Kt (-6 /-2.1% y-o-y).Alt URL
/ref> The company aims to become net neutral carbon by 2040.

Pharmaceuticals

The following is a list of key pharmaceutical products: ''Cardiovascular diseases'' *Avalide (

irbesartan Irbesartan, sold under the brand name Avapro among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versi ...

hydrochlorothiazide Hydrochlorothiazide is a diuretic medication often used to treat high blood pressure and swelling due to fluid build-up. Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in ...

) – comarketed with

Sanofi Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Originally, the corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Syn ...

*Avapro (

) – comarketed with

*Coumadin (

warfarin Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to prevent blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent st ...

) *Eliquis (

apixaban Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. Specifically it i ...

) – comarketed with

Pfizer Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...

*Plavix (

clopidogrel Clopidogrel — sold under the brand name Plavix, among others — is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following ...

) – comarketed with

*Pravachol (

pravastatin Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. It should be used together with diet changes, exercise, and w ...

) ''Diabetes mellitus'' *Bydureon (

exenatide Exenatide, sold under the brand name Byetta and Bydureon among others, is a medication used to treat diabetes mellitus type 2. It is used together with diet, exercise, and potentially other antidiabetic medication. It is a treatment option after ...

extended-release) – marketed by BMS only in some countries *Byetta (

) – marketed by BMS only in some countries, such as

Russian Federation Russia (, , ), or the Russian Federation, is a transcontinental country spanning Eastern Europe and Northern Asia. It is the largest country in the world, with its internationally recognised territory covering , and encompassing one-eig ...

*Farxiga/Forxiga (

dapagliflozin Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat type 2 diabetes. It is also used to treat adults with heart failure and chronic kidney disease. Common side effects include hy ...

) *Glucophage (

metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. ...

) – marketed by BMS only in USA *Glucophage XR (

extended release) – marketed by BMS only in USA *Glucovance ( Glyburide/metformin) – marketed by BMS only in USA *Kombiglyze XR/Komboglyze (

saxagliptin Saxagliptin, sold under the brand name Onglyza, is an oral hypoglycemic ( anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Early development was solely by Bristol-Myers Squibb; in 2007 AstraZeneca joined with Bristol-My ...

extended release) – comarketed with

*Onglyza (

) – comarketed with

''Infectious diseases, including

HIV infection Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ma ...

and associated conditions'' * Atripla ( efavirenz/

emtricitabine Emtricitabine (commonly called FTC, systematic name 2',3'-dideoxy-5-fluoro-3'-thiacytidine), with trade name Emtriva (formerly Coviracil), is a nucleoside reverse-transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection i ...

/ tenofovir disoproxil fumarate) – comarketed with

*Azactam (

aztreonam Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as ''Pseudomonas aeruginosa''. This may include bone infections, endometritis, intra abdominal ...

) *Baraclude (

entecavir Entecavir (ETV), sold under the brand name Baraclude, is an antiviral medication used in the treatment of hepatitis B virus (HBV) infection. In those with both HIV/AIDS and HBV antiretroviral medication should also be used. Entecavir is taken by ...

) *Daklinza (

daclatasvir Daclatasvir, sold under the brand name Daklinza, is an antiviral medication used in combination with other medications to treat hepatitis C (HCV). The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depe ...

) *Evotaz (

atazanavir/cobicistat Atazanavir/cobicistat, sold under the brand name Evotaz, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS. It contains atazanavir and cobicistat. Atazanavir is an HIV protease inhibitor and cobicistat is an ...

) *Megace (

megestrol acetate Megestrol acetate (MGA), sold under the brand name Megace among others, is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia.https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/ ...

) *Reyataz (

atazanavir Atazanavir, sold under the brand name Reyataz among others, is an antiretroviral medication used to treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention after a needlestick injury or other ...

) *Sustiva/Stocrin ( efavirenz) *Videx (

didanosine Didanosine (ddI, DDI), sold under the brand name Videx, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor ...

) *Videx EC (

delayed-release) *Zerit (

stavudine Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention after a needlestick ...

) ''Inflammatory disorders'' *Kenalog-10 (

triamcinolone acetonide Triamcinolone acetonide, sold under the brand name Kenalog among others, is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to trea ...

) *Kenalog-40 (triamcinolone acetonide) ''Oncology'' *Abecma (

idecabtagene vicleucel Idecabtagene vicleucel, sold under the brand name Abecma, is a cell-based gene therapy to treat multiple myeloma. The most common side effects include cytokine release syndrome (CRS), infections, fatigue, musculoskeletal pain, and a weakened ...

) *BiCNU ( carmustine) *Breyanzi ( lisocabtagene maraleucel) *CeeNU (

lomustine Lomustine (INN); abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a high ...

) *Droxia/Hydrea (

hydroxycarbamide Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cell disease it increases fetal hemoglobin and ...

) *Empliciti (

Elotuzumab Elotuzumab, sold under the brand name Empliciti, is a humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone, for adults that have received 1 to 3 prior therapies for the treatment of multiple myeloma ...

) *Erbitux (

cetuximab Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal a ...

) *Etopophos (

etoposide Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. It is ...

) *Ixempra (

ixabepilone Ixabepilone ( INN; also known as azaepothilone B, codenamed BMS-247550) is a pharmaceutical drug developed by Bristol-Myers Squibb as a chemotherapeutic medication for cancer. History Ixabepilone is a semi-synthetic analog of epothilone B, a na ...

) *Lysodren (

mitotane Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. It is a derivative of the early insecticid ...

) *Megace (

) *Opdivo (

) is a programmed death receptor blocking antibody used for the treatment of unresectable or metastatic melanoma and metastatic squamous

non-small-cell lung carcinoma Non-small-cell lung cancer (NSCLC) is any type of epithelial lung cancer other than small-cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to s ...

. In contrast to traditional chemotherapies and targeted anti-cancer therapies, which exert their effects by direct cytotoxic or tumor growth inhibition, nivolumab acts by inducing the immune system to attack the tumor. *Sprycel (

dasatinib Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that ar ...

) *Taxol (

paclitaxel Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical canc ...

). At one time, BMS held the solitary contract to harvest the bark of endangered yew trees on United States territory for the manufacture of

chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothe ...

drug

(Taxol). Current paclitaxel production comes from renewable sources. BMS also held the original paclitaxel license, but there are now multiple generic producers. *Vumon ( teniposide) *Yervoy (

ipilimumab Ipilimumab, sold under the brand name Yervoy, is a monoclonal antibody medication that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system. Cytotoxic T lymphocytes (CTLs) can recogniz ...

) ''Psychiatry'' *Abilify (

aripiprazole Aripiprazole, sold under the brand names Abilify and Aristada among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressiv ...

comarketed with

Otsuka Pharmaceutical (), abbreviated OPC, is a pharmaceutical company headquartered in Tokyo, Osaka and Naruto, Japan. The company was established August 10, 1964. History OPC's parent company Otsuka Holdings Co. Ltd. joined the Tokyo Stock Exchange through an ini ...

) ''Rheumatic disorders'' *Orencia (

abatacept Abatacept, sold under the brand name Orencia, is a medication used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody. Abatacept is a fusion protein composed of ...

) ''Transplant rejection'' *Nulojix (

belatacept Belatacept, sold under the brand name Nulojix, is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T cell costimulation, se ...

)

Out of production

Divested brands

(Former Bristol-Myers brands, now divested) * Bufferin * Excedrin * Ban Deodorant *Vitalis (hair tonic) *Ammens (medicated powder) *Final Net (hair spray) *Comtrex (cold relief capsules) *

Keri Keri () is a Hebrew term which literally means "happenstance", "frivolity" or "contrariness" and has come to mean seminal emission. The term is generally used in Jewish law to refer specifically to the regulations and rituals concerning the emiss ...

(lotion)

Products under development

The following is a selective list of investigational products under development, as of 2015: *

Beclabuvir Beclabuvir (also known by the research name BMS-791325; abbreviated BCV) is an antiviral drug for the treatment of hepatitis C virus (HCV) infection that has been studied in clinical trials. In February 2017, Bristol-Myers Squibb began sponsoring ...

(BMS-791325) – phase III * BMS-906024 – phase I * BMS-955176 – phase II * Brivanib alaninate (BMS-582664) – development terminated *

(BMS-901608) – phase III *

Fostemsavir Fostemsavir, sold under the brand name Rukobia, is an antiretroviral medication for adults living with HIV/AIDS who have tried multiple HIV medications and whose HIV infection cannot be successfully treated with other therapies because of resista ...

(BMS-663068) – approved in the United States in July 2020 * Lirilumab (BMS-986015) * Lulizumab pegol (BMS-931699) – phase II

Public-private engagement

Bristol-Myers Squibb engages with the public and private sectors in a variety of settings including to promote research and development, academic funding, event sponsorship, philanthropy, and

political lobbying In politics, lobbying, persuasion or interest representation is the act of lawfully attempting to influence the actions, policies, or decisions of government officials, most often legislators or members of regulatory agencies. Lobbying, whi ...

Academia and education

Institute for Advanced Study The Institute for Advanced Study (IAS), located in Princeton, New Jersey, in the United States, is an independent center for theoretical research and intellectual inquiry. It has served as the academic home of internationally preeminent schola ...

- Gift matching and direct donor. * Mentoring in IBD - Sponsor. *

Northern Ontario School of Medicine Northern Ontario School of Medicine University (NOSM University; french: Université de l'École de médecine du Nord de l'Ontario) is a public medical university in the Canadian province of Ontario. It is mandated both to educate doctors and t ...

(NOSM) - Donor. * Population Health Research Institute (PHRI) at

McMaster University Medical School The Michael G. DeGroote School of Medicine, known as the McMaster University School of Medicine prior to 2004, is the medical school of McMaster University in Hamilton, Ontario, Canada. It is operated by the McMaster Faculty of Health Sciences. ...

- Partner. *

University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park (Toronto), Queen's Park. It was founded by royal charter in 1827 ...

- Donor. *

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattl ...

- Donor.

Conferences and events

* Women in Medicine Summit - Sponsor. * World Neuroscience Innovation Forum - Sponsor.

Healthcare

Centre for Addiction and Mental Health The Centre for Addiction and Mental Health (CAMH, pronounced , french: Centre de toxicomanie et de santé mentale) is a psychiatric teaching hospital located in Toronto and ten community locations throughout the province of Ontario, Canada. It re ...

(CAMH) - Donor. *

Princess Margaret Cancer Centre The Princess Margaret Cancer Centre (previously, ''Princess Margaret Hospital'') is a scientific research centre and a teaching hospital in Toronto, Ontario, Canada, affiliated with the University of Toronto Faculty of Medicine as part of the Univ ...

(PMCC) - Foundation donor and sponsor for the PMCC Conference. *

Scarborough Health Network Scarborough Health Network (SHN) is a hospital network in Scarborough, Toronto, Ontario, Canada. It operates the Scarborough General, Centenary, and Birchmount hospitals. The three are major community health hospitals with teaching affiliations ...

(SHN) - Donor to the Scarborough Health Foundation. * SickKids - Donor to the SickKids Foundation. *

Sinai Health System The Sinai Health is a hospital system which serves Toronto, Ontario, Canada. It comprises two hospitals, Mount Sinai Hospital (an acute care hospital) and Hennick Bridgepoint Hospital, formally Bridgepoint Active Healthcare (a rehabilitation ho ...

- Donor to the Sinai Health Foundation. * Sunnybrook Health Sciences Centre - Donor.

Media

National Geographic Society The National Geographic Society (NGS), headquartered in Washington, D.C., United States, is one of the largest non-profit scientific and educational organizations in the world. Founded in 1888, its interests include geography, archaeology, an ...

- Donor. *

National Press Foundation The National Press Foundation is a nonprofit journalism training organization. It educates journalists on complex issues and trains them in reporting tools and techniques. It recognizes and encourages excellence in journalism through its awards. ...

- Funder.

Medical societies

American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes t ...

(ASH) - Corporate supporter. * Arthritis Society - National corporate partner. * Canadian Society of Internal Medicine - Sponsor. *

European Society of Cardiology The European Society of Cardiology (ESC) is an independent non-profit, non-governmental professional association that works to advance the prevention, diagnosis and management of diseases of the heart and blood vessels, and improve scientific un ...

- Sponsor. * Spanish Cardiac Society - Partner.

Political lobbying

* BIOTECanada - Member company. BIOTECanada lobbies the Canadian government for policies favourable to the

pharmaceutical industry The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. ...

. *

Innovative Medicines Canada Innovative Medicines Canada (IMC) is a national association of pharmaceutical companies that represents the interests of the research-based pharmaceutical industry in Canada. Its membership includes biopharmaceutical companies, vaccine developers, ...

- Member. *

International Federation of Pharmaceutical Manufacturers & Associations The International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) is a trade association that represents leading innovative pharmaceutical companies at the international level and in official relations with the United Nations. I ...

(IFPMA) - Member. *

National Health Council The National Health Council (NHC) is a nonprofit association of health organizations. Its members are national health-related organizations, including leading patient advocacy groups such as the American Cancer Society, the American Heart Assoc ...

- Member. * National Pharmaceutical Council - Member. * Personalized Medicine Coalition - Member. * Pharmaceutical Advertising Advisory Board - Client. *

Pharmaceutical Research and Manufacturers of America Pharmaceutical Research and Manufacturers of America (PhRMA, pronounced ), formerly known as the Pharmaceutical Manufacturers Association, is a trade group representing companies in the pharmaceutical industry in the United States. Founded in 195 ...

- Member. * Research!America - Member.

Professional associations

* Canadian Association of Emergency Physicians (CAEP) - Corporate partner. * Canadian Rheumatology Association (CRA) - Corporate sponsor. * CARE Faculty - Sponsor. CARE is a Canadian coalition of medical specialists based in Oakville, Ontario. BMS was a sponsor for their 2021 Winter Hematology Update event. * Colorectal Cancer Canada (CRC) - Sponsor. * Health Products Stewardship Association - Member.

Research and development

* Lung Health Foundation - Partner. *

Multiple Sclerosis International Federation The Multiple Sclerosis International Federation (MSIF) was established in 1967 as an international body linking the activities of National MS societies around the world. The Federation seeks to work in worldwide partnership with Member Societies ...

- Partner. * Pinnacle Research Group - Sponsor. * Radcliffe Cardiology - Industry partner.

Scandals

Bristol-Myers Squibb,

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consi ...

and the Rockefeller Foundation are currently the subject of a $1 billion lawsuit from Guatemala for "roles in a 1940s U.S. government experiment that infected hundreds of Guatemalans with syphilis". A previous suit against the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...

government was dismissed in 2011 for the Guatemala syphilis experiments when a judge determined that the U.S. government could not be held liable for actions committed outside of the U.S.

Notes and references

External links

*
Bristol-Myers Squibb worldwide locations

Bristol-Myers Squibb Influence and Lobbying Summary – Opensecrets.org
{{Authority control 1920s initial public offerings American companies established in 1887 Manufacturing companies based in New York City Multinational companies based in New York City Biotechnology companies of the United States Companies listed on the New York Stock Exchange Pharmaceutical companies established in 1887 Pharmaceutical companies of the United States Publicly traded companies based in New York City 1887 establishments in New York (state) National Medal of Technology recipients Orphan drug companies Life sciences industry

History

Squibb

Bristol-Myers

Merger

2000 to 2010

2010 onward

Corporate acquisitions and divestments as Bristol Myers Squibb

List of mergers and acquisitions

Finances

Carbon footprint

Pharmaceuticals

Out of production

Divested brands

Products under development

Public-private engagement

Academia and education

Conferences and events

Healthcare

Media

Medical societies

Political lobbying

Professional associations

Research and development

Scandals

See also

Notes and references

External links