Brigid L. M. Hogan FRS is a

developmental biologist Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem c ...

noted for her contributions to mammalian development,

stem cell research In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

and

transgenic A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another. The introduction of a transgene, in a process known as transgenesis, has the potential to change the ...

technology and techniques. She is currently a Professor in the Department of Cell Biology at

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

,http://www.cellbio.duke.edu/brigid-l-m-hogan/ Duke University Faculty Page Born in the UK, she became an American citizen in 2000. Hogan earned her PhD in Biochemistry at the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

and did postdoctoral work in the Department of Biology at

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ...

. She was the head of the Laboratory of Molecular Embryology at the

National Institute for Medical Research The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR b ...

in London, and later Hortense B. Ingram Professor in the Department of Cell Biology and a founding director of the Stem Cell and Organogenesis Program at

Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...

."Scientist At Work: Brigid Hogan; In the Ethics Storm on Human Embryo Research"
''The New York Times'', Nicholas Wade, 28 September 1999. In 2002, she moved to Duke University. Her work on mouse development led her to organize the first Molecular Embryology of the Mouse course at

Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers ...

and edit the first two editions of ''Manipulating the Mouse Embryo: A Laboratory Manual'', considered the "Bible" of mammalian embryo manipulation techniques. She has served as President of the American Society for Developmental Biology and the

American Society for Cell Biology The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960.National Institute of Child Health and Human Development The ''Eunice Kennedy Shriver'' National Institute of Child Health and Human Development (NICHD) is one of the National Institutes of Health (NIH) in the United States Department of Health and Human Services. It supports and conducts research aime ...

, Co-Chair for Science of the 1994 NIH Human Embryo Research Panel and a member of the 2001/2002 National Academies Panel on Scientific and Medical Aspects of Human Cloning. She was awarded the sixth International Society for Transgenic Technologies Prize in 2008 for "outstanding contributions to the field of transgene technologies".http://transtechsociety.org/blog/?p=20 ISTT Prize awarded to Brigid Hogan She delivered a 2011 Martin Rodbell Lecture, hosted by the

National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) conducts research into the effects of the environment on human disease, as one of the 27 institutes and centers of the National Institutes of Health (NIH). It is located in the Rese ...

and the Croonian Lecture of the Royal Society of London in 2014.

Early life

Hogan was born in Denham, a small village near London. Both of her parents were artists. As a child she faced the difficulties of post-World War II Britain. Her father, a stage designer, died in 1945 shortly after coming back from the front lines. Her single mother, a dressmaker, raised her and her sibling. She was a support and inspiration to Hogan. The village Hogan grew up in was close to nature and fostered her love for biology. Her rational scientific thinking helped her cope with her uncertain home life. She attended a High Wycombe High School for girls, where her biology teacher mentored her as she applied to Cambridge University. She was admitted to Newnham College, Cambridge's all-women's college, where she faced negative attitudes from male faculty due to her gender, typical of the time. American Society for Cell Biology Member Profile

Career

Since Cambridge offered no courses in cell or developmental biology at the time, Hogan did her post-doctorate work on sea urchin development with Paul Gross at MIT. Around 1974, back in Britain, Hogan began her work on mouse embryonic stem cells at the Mill Hill Labs of the

Imperial Cancer Research Fund Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

in London under director John Cairns. Encouraged by

Anne McLaren Dame Anne Laura Dorinthea McLaren, (26 April 1927 – 7 July 2007) was a British scientist who was a leading figure in developmental biology. Her work helped lead to human in vitro fertilisation (IVF), She was the head of the Laboratory of Molecular Embryology at the Imperial Cancer Research Fund and then the National Institute of Medical Research in London. Her student, Peter Holland, became well known for his work on vertebrate evolution and was awarded the

Darwin Medal The Darwin Medal is one of the medals awarded by the Royal Society for "distinction in evolution, biological diversity and developmental, population and organismal biology". In 1885, International Darwin Memorial Fund was transferred to the ...

of the Royal Society in 2019. In 1988, she was recruited to

Vanderbilt University Medical Center The Vanderbilt University Medical Center (VUMC) is a medical provider with multiple hospitals in Nashville, Tennessee, as well as clinics and facilities throughout Middle Tennessee. VUMC is an independent non-profit organization, but maintains acad ...

by Hal Moses. There she was a Professor of Cell Biology and Hortense B. Ingram Chair of Molecular Oncology, as well as the co-founder of the Stem Cell and Organogenesis Program.http://www.mc.vanderbilt.edu:8080/reporter/index.html?ID=2068 Hogan leaving VUMC to head Duke program From 1993-2002 she was an Investigator of the Howard Hughes Medical Institute. At Vanderbilt University, she grew to appreciate the American enthusiasm towards scientific study in general and towards women in the scientific field in particular. She considers her work at Vanderbilt “one of the most productive and exciting” in her career. She left Vanderbilt in 2002 after 13 years to head the department of Cell Biology at

Duke University Medical Center Duke University Hospital is a 957-acute care bed academic tertiary care facility located in Durham, North Carolina. Established in 1930, it is the flagship teaching hospital for the Duke University Health System, a network of physicians and hosp ...

, making her the first woman to chair a basic sciences department there. At Duke University, she was George Barth Geller Professor of Molecular Biology from 2002-2018 before stepping down as Chair in 2019. She continues to plan an active role in the Cell Biology Department and the Developmental and Stem Cell training program. Her lab studied the lung, due to it developing through "branching morphogenesis". To facilitate this, she created numerous mouse lines where genes can be manipulated in specific lung cells. She is particularly interested in the stem cells of the mouse lung as models for human lung cells that are often affected by disease. She hopes to apply her research to

Chronic Obstructive Pulmonary Disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by long-term respiratory symptoms and airflow limitation. The main symptoms include shortness of breath and a cough, which may or may not produce ...

cystic fibrosis Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. O ...

, chronic

asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, cou ...

pulmonary fibrosis Pulmonary fibrosis is a condition in which the lungs become scarred over time. Symptoms include shortness of breath, a dry cough, feeling tired, weight loss, and nail clubbing. Complications may include pulmonary hypertension, respiratory failu ...

, and

premature babies Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 2 ...

with inadequate lung development.

Awards and recognition

* 1986 –

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

member * 1993–2002 –

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

Investigator * 1996 –

Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, E ...

member * 2001 –

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

* 2001 – American Society for Developmental Biology President * 2001 –

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

Fellow * 2003 –

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

memberhttp://news.vanderbilt.edu/archived-news/register/articles/index-id=5638.html VUMC scientist elected AAAS Fellow * 2005 –

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

member * 2008 – International Society for Transgenic Technologies Prize * 2009 –

American Society for Cell Biology The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960.2008 Cold Spring Harbor Laboratory Symposium Lecture

2014 Croonian Lecture

Discoveries and ongoing projects in the Hogan laboratory
{{DEFAULTSORT:Hogan, Brigid 1943 births 20th-century British biologists 21st-century British biologists British women biologists Duke University faculty Fellows of the American Academy of Arts and Sciences Fellows of Newnham College, Cambridge Fellows of the Royal Society Female Fellows of the Royal Society Howard Hughes Medical Investigators Living people Members of the United States National Academy of Sciences National Institute for Medical Research faculty Vanderbilt University faculty Members of the National Academy of Medicine