Biotin/lipoyl attachment
domain
Domain may refer to:
Mathematics
*Domain of a function, the set of input values for which the (total) function is defined
**Domain of definition of a partial function
**Natural domain of a partial function
**Domain of holomorphy of a function
* Do ...
has a conserved lysine residue that binds
biotin
Biotin (or vitamin B7) is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids. The name ''biotin'', bor ...
or
lipoic acid
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA is made in animals normally, and is essential for aerobic metabolism. It is a ...
. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme.
s have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group.
The lipoic acid cofactor is found in a variety of proteins.
Human proteins containing this domain
ACACA;
ACACB
Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ''ACACB'' gene.
Function
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which cat ...
;
DBT;
DLAT;
DLST;
DLSTP;
MCCC1;
PC;
PCCA;
PDHX;
References
{{DEFAULTSORT:Biotin Attachment Domain
Protein domains