Bromodomain-containing protein 9 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''BRD9''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
[
]
Structure and interaction
BRD9 contains a
bromodomain
A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the ''N''-terminal tails of histones. Bromodomains, as the "readers" of lysine acetylation, are responsible in transducin ...
. It is closely related to
BRD7
Bromodomain-containing protein 7 is a protein that in humans is encoded by the ''BRD7'' gene.
Interactions
BRD7 has been shown to interact with IRF2 and HNRPUL1.
Azoospermia
BRD7 protein is a transcription regulator that is normally highly e ...
. BRD9 is present in some
SWI/SNF
In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes. In other words, it is a group of proteins that associate to remodel the way DNA is packa ...
ATPase remodeling complexes.
Role in cancer
The BRD9 gene is frequently present in variable copy number in lung cancer.
Small molecule inhibition
Small molecules capable of binding to the bromodomain of BRD9 have been developed.
See also
Bromodomain
A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the ''N''-terminal tails of histones. Bromodomains, as the "readers" of lysine acetylation, are responsible in transducin ...
References
Human proteins
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