In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45

amino acids Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...

found in the adaptor proteins

Grb7 Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the ''GRB7'' gene. Function The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number ...

/, Grb10/

Grb14 Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the ''GRB14'' gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and ...

. It mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the

substrate Substrate may refer to: Physical layers *Substrate (biology), the natural environment in which an organism lives, or the surface or medium on which an organism grows or is attached ** Substrate (locomotion), the surface over which an organism lo ...

peptide groove of the kinase, acting as a pseudosubstrate inhibitor. It is composed of two

beta strands Beta (, ; uppercase , lowercase , or cursive ; grc, βῆτα, bē̂ta or ell, βήτα, víta) is the second letter of the Greek alphabet. In the system of Greek numerals, it has a value of 2. In Modern Greek, it represents the voiced labio ...

and a C-terminal helix.

References

Protein domains {{protein-stub