Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a
protein that in humans is encoded by the ''BIRC2''
gene.
Function
cIAP1 is a member of the
Inhibitor of Apoptosis family that inhibit
apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
by interfering with the activation of
caspases
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. They are named caspases due to their specific cystei ...
.
Interactions
BIRC2 has been shown to
interact with:
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CASP9,
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DIABLO,
[
* HSP90B1,]HTRA2
Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the ''HTRA2'' gene. This protein is involved in caspase-dependent apoptosis and in Parkinson's disease.
Structure Gene
The gene ''HTRA2'' encodes a serine protease. T ...
,
References
Further reading
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External links
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{{PDB Gallery, geneid=329
Proteins
Microbiology