Bcl-2-like protein 1 is a protein encoded in humans by the ''BCL2L1''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. Through alternative splicing, the gene encodes both of the human proteins

Bcl-xL B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondr ...

and Bcl-xS.

Function

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-

apoptotic Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes ( morphology) and death. These changes incl ...

regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the

outer mitochondrial membrane A mitochondrion (; ) is an organelle found in the cells of most Eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is use ...

, and have been shown to regulate outer mitochondrial membrane channel (

voltage-dependent anion channel Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major pro ...

s (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of

reactive oxygen species In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (). Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen () p ...

and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (

) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.

Interactions

BCL2-like 1 (gene) has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: *

APAF1 Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of ''C. elegans'' CED-4 gene. Function The protein was identified in the lab of Xiaodong Wang as an activator of caspase-3 in the presense of cytochromeC and dATP ...

, * BAK1, *

BCAP31 B-cell receptor-associated protein 31 is a protein that in humans is encoded by the ''BCAP31'' gene. Interactions BCAP31 has been shown to interact with: * APP, * BCL2L1, * BCL2, * CASP8, and * VAMP3 Vesicle-associated membrane protein 3 ...

, *

BCL2L11 Bcl-2-like protein 11, commonly called BIM (Bcl-2 Interacting Mediator of cell death), is a protein that in humans is encoded by the ''BCL2L11'' gene. Function The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family ...

, *

BNIP3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the ''BNIP3'' gene. BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. ...

, *

BNIPL Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the ''BNIPL'' gene. Interactions BNIPL has been shown to interact with: * BCL2-like 1, * Bcl-2 Bcl-2 (B-cell lymphoma 2), encoded in ...

, * BAD, * BAX, * BIK, *

Bcl-2 Bcl-2 (B-cell lymphoma 2), encoded in humans by the ''BCL2'' gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosi ...

, * HRK, *

IKZF3 Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the ''IKZF3'' gene. Function This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this ...

, *

Noxa Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the ''PMAIP1'' gene, and is also known as Noxa. Noxa (Latin for ''damage'') is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members c ...

, *

PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the ''PPP1CA'' gene. Function The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP ...

, * PSEN2 *

RAD9A Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the ''RAD9A'' gene.''Rad9'' has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. ''Rad9'' was originally found in buddin ...

, *

RTN1 Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the ''RTN1'' gene. This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, an ...

, * RTN4, and *

VDAC1 Voltage-dependent anion-selective channel 1 (VDAC-1) is a beta barrel protein that in humans is encoded by the ''VDAC1'' gene located on chromosome 5. It forms an ion channel in the outer mitochondrial membrane (OMM) and also the outer cell membra ...

References

External links

* {{PDB Gallery, geneid=598 Proteins Apoptosis

Function

Interactions

References

Further reading

External links