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An eyelid is a thin fold of skin that covers and protects an
eye Eyes are organs of the visual system. They provide living organisms with vision, the ability to receive and process visual detail, as well as enabling several photo response functions that are independent of vision. Eyes detect light and conv ...
. The levator palpebrae superioris muscle retracts the eyelid, exposing the cornea to the outside, giving vision. This can be either voluntarily or involuntarily. The human eyelid features a row of
eyelash An eyelash (also called lash) (Latin: ''Cilia'') is one of the hairs that grows at the edge of the eyelids. It grows in one layer on the edge of the upper and lower eyelids. Eyelashes protect the eye from debris, dust, and small particles and p ...
es along the eyelid margin, which serve to heighten the protection of the eye from dust and foreign debris, as well as from perspiration. "Palpebral" (and "blepharal") means relating to the eyelids. Its key function is to regularly spread the tears and other secretions on the eye surface to keep it moist, since the cornea must be continuously moist. They keep the eyes from drying out when asleep. Moreover, the
blink Blinking is a bodily function; it is a semi-autonomic rapid closing of the eyelid. A single blink is determined by the forceful closing of the eyelid or inactivation of the levator palpebrae superioris and the activation of the palpebral portio ...
reflex protects the eye from foreign bodies. The appearance of the human upper eyelid often varies between different populations. The prevalence of an epicanthic fold covering the inner corner of the eye account for the majority of
East Asian East Asia is the eastern region of Asia, which is defined in both geographical and ethno-cultural terms. The modern states of East Asia include China, Japan, Mongolia, North Korea, South Korea, and Taiwan. China, North Korea, South Korea a ...
and
Southeast Asian Southeast Asia, also spelled South East Asia and South-East Asia, and also known as Southeastern Asia, South-eastern Asia or SEA, is the geographical south-eastern region of Asia, consisting of the regions that are situated south of mainland ...
populations, and is also found in varying degrees among other populations. Separately, but also similarly varying between populations, the crease of the remainder of the eyelid may form either a "single eyelid", a "double eyelid", or an intermediate form. Eyelids can be found in other animals, some of which may have a third eyelid, or
nictitating membrane The nictitating membrane (from Latin '' nictare'', to blink) is a transparent or translucent third eyelid present in some animals that can be drawn across the eye from the medial canthus to protect and moisten it while maintaining vision. All ...
. A vestige of this in humans survives as the plica semilunaris.


Structure


Layers

The eyelid is made up of several layers; from superficial to deep, these are: skin,
subcutaneous tissue The subcutaneous tissue (), also called the hypodermis, hypoderm (), subcutis, superficial fascia, is the lowermost layer of the integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and macr ...
, orbicularis oculi, orbital septum and tarsal plates, and palpebral conjunctiva. The meibomian glands lie within the eyelid and secrete the lipid part of the
tear film Tears are a clear liquid secreted by the lacrimal glands (tear gland) found in the eyes of all Mammal, land mammals. Tears are made up of water, electrolytes, proteins, lipids, and mucins that form layers on the surface of eyes. The different ty ...
.


Skin

The skin is similar to areas elsewhere, but is relatively thin and has more pigment cells. In diseased persons these may wander and cause a discoloration of the lids. It contains sweat glands and hairs, the latter becoming eyelashes as the border of the eyelid is met. The skin of the eyelid contains the greatest concentration of sebaceous glands found anywhere in the body.


Nerve supply

In humans, the sensory nerve supply to the upper eyelids is from the
infratrochlear The infratrochlear nerve is a branch of the nasociliary nerve, itself a branch of the ophthalmic nerve. Structure The nasociliary nerve terminates by bifurcating into the infratrochlear and the anterior ethmoidal nerves. The infratrochlear ne ...
,
supratrochlear The supratrochlear nerve is a branch of the frontal nerve, itself a branch of the ophthalmic nerve (CN V1) from the trigeminal nerve (CN V). It provides sensory innervation to the skin of the forehead and the upper eyelid. Structure The suprat ...
,
supraorbital Supraorbital refers to the region immediately above the eye sockets, where in humans the eyebrows are located. It denotes several anatomical features, such as: *Supraorbital artery *Supraorbital foramen *Supraorbital gland *Supraorbital nerve *Sup ...
and the lacrimal nerves from the ophthalmic branch (V1) of the trigeminal nerve (CN V). The skin of the lower eyelid is supplied by branches of the
infratrochlear The infratrochlear nerve is a branch of the nasociliary nerve, itself a branch of the ophthalmic nerve. Structure The nasociliary nerve terminates by bifurcating into the infratrochlear and the anterior ethmoidal nerves. The infratrochlear ne ...
at the medial angle. The rest is supplied by branches of the
infraorbital nerve The infraorbital nerve is a branch of the maxillary nerve, itself a branch of the trigeminal nerve (CN V). It travels through the orbit and enters the infraorbital canal to exit onto the face through the infraorbital foramen. It provides sensory ...
of the maxillary branch (V2) of the trigeminal nerve.


Blood supply

In humans, the eyelids are supplied with blood by two arches on each upper and lower lid. The arches are formed by anastomoses of the lateral palpebral arteries and medial palpebral arteries, branching off from the lacrimal artery and ophthalmic artery, respectively.


Function

The human eyelid features a row of eyelashes along the eyelid margin, which serve to heighten the protection of the eye from dust and foreign debris.


Clinical significance

Any condition that affects the eyelid is called eyelid disorder. The most common eyelid disorders, their causes, symptoms and treatments are the following: * Hordeolum ( stye) is an infection of the sebaceous glands of Zeis usually caused by ''
Staphylococcus aureus ''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often positive ...
'' bacteria, similar to the more common condition
Acne vulgaris Acne, also known as ''acne vulgaris'', is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles. Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and po ...
. It is characterized by an acute onset of symptoms and it appears similar to a red bump placed underneath the eyelid. The main symptoms of styes include pain, redness of the eyelid and sometimes swollen eyelids. Styes usually disappear within a week without treatment. Otherwise,
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
s may be prescribed and home remedies such as warm water compresses may be used to promote faster healing. Styes are normally harmless and do not cause long lasting damage. * Chalazion (plural: chalazia) is caused by the obstruction of the oil glands and can occur in both upper and lower eyelids. Chalazia may be mistaken for styes due to the similar symptoms. This condition is however less painful and it tends to be chronic. Chalazia heal within a few months if treatment is administered and otherwise they can resorb within two years. Chalazia that do not respond to topical medication are usually treated with surgery as a last resort. *
Blepharitis Blepharitis is one of the most common ocular conditions characterized by inflammation, scaling, reddening, and crusting of the eyelid. This condition may also cause swelling, burning, itching, or a grainy sensation when introducing foreign objects ...
is the irritation of the lid margin, where eyelashes join the eyelid. This is a common condition that causes inflammation of the eyelids and which is quite difficult to manage because it tends to recur. This condition is mainly caused by staphylococcus infection and scalp dandruff. Blepharitis symptoms include burning sensation, the feeling that there is something in the eye, excessive tearing, blurred vision, redness of the eye, light sensitivity, red and swollen eyelids, dry eye and sometimes crusting of the eyelashes on awakening. Treatment normally consists in maintaining a good hygiene of the eye and holding warm compresses on the affected eyelid to remove the crusts. Gently scrubbing the eyelid with the warm compress is recommended as it eases the healing process. In more serious cases, antibiotics may be prescribed. * '' Demodex'' mites are a genus of tiny mites that live as commensals in and around the
hair follicle The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction between h ...
s of numerous mammals including humans, cats and dogs. Human demodex mites typically live in the follicles of the eyebrows and eyelashes. While normally harmless, human demodex mites can sometimes cause irritation of the skin ( demodicosis) in persons with weakened immune systems. * Entropion usually results from aging, but sometimes can be due to a congenital defect, a spastic eyelid muscle, or a scar on the inside of the lid that could be from surgery, injury, or disease. It is an
asymptomatic In medicine, any disease is classified asymptomatic if a patient tests as carrier for a disease or infection but experiences no symptoms. Whenever a medical condition fails to show noticeable symptoms after a diagnosis it might be considered asy ...
condition that can, rarely, lead to trichiasis, which requires surgery. It mostly affects the lower lid, and is characterized by the turning inward of the lid, toward the globe. * Ectropion is another aging-related eyelid condition that may lead to chronic eye irritation and scarring. It may also be the result of allergies and its main symptoms are pain, excessive tearing and hardening of the eyelid conjunctiva. * Laxity is also another aging-related eyelid condition that can lead to dryness and irritation. Surgery may be necessary to repair the eyelid to its natural position. In certain instances, excessive lower lid laxity creates the Fornix of Reiss – a pocket between the lower eyelid and globe – which is the ideal location to administer topical ophthalmic medications. * Eyelid
edema Edema, also spelled oedema, and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's Tissue (biology), tissue. Most commonly, the legs or arms are affected. Symptoms may include skin which feels t ...
is a condition in which the eyelids are swollen and tissues contain excess fluid. It may affect eye function when it increases the intraocular pressure. Eyelid edema is caused by allergy, trichiasis or infections. The main symptoms are swollen red eyelids, pain, and itching. Chronic eyelid edema can lead to
blepharochalasis Blepharochalasis is an inflammation of the eyelid that is characterized by exacerbations and remissions of eyelid edema, which results in a stretching and subsequent atrophy of the eyelid tissue, leading to the formation of redundant folds over ...
. * Eyelid tumors may also occur. Basal cell carcinomas are the most frequently encountered kind of cancer affecting the eyelid, making up 85% to 95% of all malignant eyelid tumors. The tumors may be benign or malignant. Usually benign tumors are localized and removed before becoming a cancerous threat and before they become large enough to impair vision. Malignant tumors on the other hand tend to spread to surrounding areas and tissues. *
Blepharospasm Blepharospasm is any abnormal contraction of the orbicularis oculi muscle. The condition should be distinguished from the more common, and milder, involuntary quivering of an eyelid, known as myokymia, or fasciculation. In most cases, blepharosp ...
(eyelid twitching) is an involuntary spasm of the eyelid muscle. The most common factors that make the muscle in the eyelid twitch are fatigue, stress, and caffeine. Eyelid twitching is not considered a harmful condition and therefore there is no treatment available. Patients are however advised to get more sleep and drink less caffeine. *
Eyelid dermatitis Eyelid dermatitis is commonly related to atopic dermatitis or allergic contact dermatitis. Volatile substances, tosylamide, epoxy hardeners, insect sprays, and lemon peel oil may be implicated, with many cases of eyelid contact dermatitis being ...
is the inflammation of the eyelid skin. It is mostly a result of allergies or contact dermatitis of the eyelid. Symptoms include dry and flaky skin on the eyelids and swollen eyelids. The affected eyelid may itch. Treatment consists in proper eye hygiene and avoiding the allergens that trigger the condition. In rare cases,
topical cream A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
s may be used but only under a doctor's supervision. * Ptosis (drooping eyelid) is when the upper eyelid droops or sags due to weakness or paralysis of the levator muscle (responsible for raising the eyelid), or due to damage to nerves controlling the muscle. It can be a manifestation of the normal aging process, a congenital condition, or due to an injury or disease. Risk factors related to ptosis include diabetes, stroke, Horner syndrome, Bell's Palsy (compression/damage to Facial nerve), myasthenia gravis, brain tumor or other cancers that can affect nerve or muscle function. * Ablepharia (ablepharon) is the congenital absence of or reduction in the size of the eyelids.


Surgery

The eyelid surgeries are called blepharoplasties and are performed either for medical reasons or to alter one's facial appearance. Most of the cosmetic eyelid surgeries are aimed to enhance the look of the face and to boost self-confidence by restoring a youthful eyelid appearance. They are intended to remove fat and excess skin that may be found on the eyelids after a certain age. Eyelid surgeries are also performed to improve peripheral vision or to treat chalazion, eyelid tumors, ptosis, extropion, trichiasis, and other eyelid-related conditions. Eyelid surgeries are overall safe procedures but they carry certain risks since the area on which the operation is performed is so close to the eye.


Anatomical variation

An anatomical variation in humans occurs in the creases and folds of the upper eyelid. An epicanthic fold, the skin fold of the upper eyelid covering the inner corner (medial canthus) of the eye, may be present based on various factors, including ancestry, age, and certain medical conditions. In some populations the trait is almost universal, specifically in East Asians and Southeast Asians, where a majority, up to 90% in some estimations, of adults have this feature.Lee, Y., Lee, E. and, Park, W.J. (2000) ''Anchor epicanthoplasty combined with outfold type double eyelidplasty for Asians: do we have to make an additional scar to correct the Asian epicanthal fold?'' Plast. Reconstr. Surg. 105:1872–1880 The upper eyelid crease is a common variation between people of
Caucasian Caucasian may refer to: Anthropology *Anything from the Caucasus region ** ** ** ''Caucasian Exarchate'' (1917–1920), an ecclesiastical exarchate of the Russian Orthodox Church in the Caucasus region * * * Languages * Northwest Caucasian l ...
and
East Asian East Asia is the eastern region of Asia, which is defined in both geographical and ethno-cultural terms. The modern states of East Asia include China, Japan, Mongolia, North Korea, South Korea, and Taiwan. China, North Korea, South Korea a ...
ethnicities. Westerners commonly perceive the East Asian upper eyelid as a "single eyelid". However, East Asian eyelids are divided into three types – single, low, and double – based on the presence or position of the lid crease. Jeong Sang-ki et al. of Chonnam University, Kwangju, Korea, in a study using both Asian and Caucasian
cadaver A cadaver or corpse is a dead human body that is used by medical students, physicians and other scientists to study anatomy, identify disease sites, determine causes of death, and provide tissue to repair a defect in a living human being. Stud ...
s as well as four healthy young Korean men, said that "Asian eyelids" have more fat in them than those of Caucasians.


Prevalence


Society and culture


Cosmetic surgery

Blepharoplasty Blepharoplasty (Greek: ''blepharon'', "eyelid" + ''plassein'' "to form") is the plastic surgery operation for correcting defects, deformities, and disfigurations of the eyelids; and for aesthetically modifying the eye region of the face. With t ...
is a cosmetic surgical procedure performed to correct deformities and improve or modify the appearance of the eyelids. With 1.43 million people undergoing the procedure in 2014, blepharoplasty is the second most popular cosmetic procedure in the world (Botulinum toxin injection is first), and the most frequently performed cosmetic surgical procedure in the world. East Asian blepharoplasty, or "double eyelid surgery", has been reported to be the most common aesthetic procedure in Taiwan and South Korea. Though the procedure is also used to reinforce muscle and tendon tissues surrounding the eye, the operative goal of East Asian blepharoplasty is to remove the adipose and linear tissues underneath and surrounding the eyelids in order to crease the upper eyelid. A procedure to remove the
epicanthal fold An epicanthic fold or epicanthus is a skin fold of the upper eyelid that covers the inner corner (medial canthus) of the eye. However, variation occurs in the nature of this feature and the possession of "partial epicanthic folds" or "slight ...
(i.e. an
epicanthoplasty Epicanthoplasty is a rare eye surgery to modify the epicanthal folds. It can be a challenging procedure because the epicanthal folds overlay the lacrimal canaliculi (tear drainage canals). Although an epicanthic fold can also be associated with a ...
) is often performed in conjunction with an East Asian blepharoplasty. The use of double sided tape or eyelid glue to create the illusion of creased, or "double" eyelids has become a prominent practice in
China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...
and other Asian countries. There is a social pressure for women to have this surgery, and also to use the alternative (taping) practices. Blepharoplasty has become a common surgical operation that is actively encouraged, whilst other kinds of plastic surgery are actively discouraged in Chinese culture.Cornell, Joanna. "In the Eyelids of the Beholder." Yale Globalist (2010): n. pag. Web. 2 Mar 2011. http://tyglobalist.org/perspectives/in-the-eyelids-of-the-beholder/


Death

After death, it is common in many cultures to pull the eyelids of the deceased down to close the eyes. This is a typical part of the
last offices The last offices, or laying out, is the procedures performed, usually by a nurse, to the body of a dead person shortly after death has been confirmed. They can vary between hospitals and between cultures. Name The word "offices" is related to the o ...
.


Additional images

File:Gray866.png, Horizontal section through the eye of an eighteen days' embryo rabbit. X 30 File:Gray888.png, Sagittal section of right orbital cavity File:Gray893.png, Sagittal section through the upper eyelid File:Gray894.png, The tarsi and their ligaments. Right eye; front view File:Gray896.png, The lacrimal apparatus. Right side File:Slide2www.JPG, Extrinsic eye muscle. Nerves of orbita. Deep dissection


See also

* Cellulitis – a bacterial infection involving the inner layers of the skin *
Dermatochalasis Dermatochalasis is a medical condition, defined as an excess of skin in the upper or lower eyelid, also known as "baggy eyes." It may be either an acquired or a congenital condition. It is generally treated with blepharoplasty. Presentation Ass ...
– an excess of eyelid skin that may obstruct vision *
Gland of Moll Moll's gland, also known as the gland of Moll or ciliary gland, is a modified apocrine sweat gland that is found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the meibomian glands within the distal eyelid ...
– a modified sweat gland at the base of the eyelashes * Hay-Wells syndrome – a disorder often causing fusion of the eyelids *
Nictitating membrane The nictitating membrane (from Latin '' nictare'', to blink) is a transparent or translucent third eyelid present in some animals that can be drawn across the eye from the medial canthus to protect and moisten it while maintaining vision. All ...
– a third eyelid present in some animals


References


Sources

*"eye, human."Encyclopædia Britannica from Encyclopædia Britannica 2006 Ultimate Reference Suite DVD 2009. {{Use dmy dates, date=April 2017 Human eye anatomy Human anatomy