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Aphidicolin is a tetracyclic diterpene
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
isolated from the fungus '' Cephalosporum aphidicola'' with antiviral and antimitotic properties. Aphidicolin is a reversible
inhibitor Inhibitor or inhibition may refer to: In biology * Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity * Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...
of eukaryotic nuclear DNA replication. It blocks the cell cycle at early
S phase S phase (Synthesis Phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is critical to successful cell division, the processes that occur during ...
. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses ( vaccinia and herpesviruses) and an
apoptosis Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus '' Nigrospora oryzae''.Aphidicolin product page
from Fermentek


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References

Antibiotics Transferase inhibitors Diterpenes Cyclopentanes DNA polymerase inhibitors {{organic-compound-stub